"Torasemide": tohutohu mō te whakamahi. "Sandoz Torasemide": utu, wāhi, arotake

"Torasemide" - he tarukino diuretic kaha hou e he tino mo te therapy wā roa-o mate e pā ana ki te ahua o te edema. Nā ki te maha iti o ngā pānga hauora nui taha, te whanui o tona whakamahi whakaora ake. Ko haumaru ki ētahi atu Diuretics koropiko reira me kua atu taunakitanga. I roto i te maimoatanga o tini o nga mate whakarerekētia te inenga te. Hoki, he mea e hāngai ana i roto i te take o te iti hoki o te tākihi mahi noa i te filtration iti nephron tere glomeruli.

Pānga "torasemide"

"Torasemide" rite te koropiko (tote) rōpū māngai Diuretics mahi i roto i te wahi luminal o te epithelium o tubules o te waepuha i roto i te wahi e piki o te koropiko o Henle. Te faaohiparaa i te pānga inhibitory i runga i te waka tahi o katote pāhare pāporo me te konutai pūhaumāota, reira tino whakaiti te pūmanawa iahiko i te epithelium mata o te waepuha. hua Tuhinga Ko ngangau o katote waka konutai reabsorption i te mimi tuatahi, e faarahi diuresis.

Tata meinga Diuretics koropiko katoa raruraru kawehiko tika ki te reabsorption mana kaha o katote pāhare pāporo, konutai, konupora me te māota. "Torasemide" ki te whānuitanga iti pā i te kōwhiringa o te konurehu me te konupora, e tika ana ki nei he pā nui raro o arrhythmias, anorexia, kōroke, uaua ngoikore. Ano, ko te tarukino ki te iti poraka whānuitanga hanganga o thromboxane A2, whakawhānui oko. Ia ano poraka aldosterone mau farii ohipa infarction, hëoi anö te tukanga o kakakīrehe o te uaua ngakau.

iteraa papû

Āpitihia ki te tarukino kei "Torasemide" ā-ako mōhiohio e pā ana ki te mate, i whakamahia e ia mo te maimoatanga. "Torasemide" te tohua hoki:

• maimoatanga pathogenetic o takawhita matua ātete ki te therapy ki ngā o inhibitors ACE (ARBs) Diuretics thiazide;
• te maimoatanga o te kore ngakau ma'i, e pā ana i te porohita kikī circulatory;
• maimoatanga symptomatic o täkihi ma'i, tae atu tātari i te tere iti (iti iho i te 20 ml \ min);
• maimoatanga symptomatic o ate (ki hypoalbuminemia e hāngai ana) edema hei kē ki "Furosemide".

A, no te takawhita "Torasemide" analogues me arowhānui e whakamahia i muri anake kore o Diuretics thiazide. He roa te tarukino taea te whakahaere hoki o te tau iti o ngā pānga taha hauora nui, me te mōrearea i roto i te täkihi. Ko te hunga o "torasemide" Ko nui iti iho i taua o "Furosemide".

Tohutohu mō te whakamahi

I runga i nga aratohu haumanu mō te tarukino ngā "Torasemide" ā-ako nga āhuatanga o toketaá tarukino hiahiatia mō te maimoatanga me te ako o te mate ūnga. Ai te tarukino ake he wātea i roto i nga papa kei roto i te kai e whai ake nei: 2.5 mg, 5 mg, 10 mg, 20 mg, 50 mg, 100 mg, 200 mg.

Ki te tango i te tarukino i runga i te papa i roto i te ata, ahakoa o te kai. Hoki enei pota o te tarukino "Torasemide" utu rerekē: ko reira raro i te horopeta iti me te teitei i te mōrahi. E ai ki nga raraunga Pine, 30 papa o te tarukino i 5 mg e pā ana ki 400 moni. A, no te fariiraa i tenei horopeta e tohaina e whai ake rite ki te tohu:

• i roto i te maimoatanga o te takawhita tangohia 2.5 - 10 mg / ra;
• riro 10-20 mg / ra mo te kore te ngakau ma'i;
• täkihi ma'i - 50 mg atu ranei;
• titau kore ate whakatikatika horopeta takitahi.

Te taha Pānga "torasemide"

Āpitihia ki te tarukino kei "Torasemide" ā-ako mōhiohio e pā ana ki ngā pānga taha maha. I te horopeta haumanu, arā ake ki te 200 mg ia ra whakanuia ana te mōrea o pōauautanga thromboembolic, ischemia cardiac, kaka. faarahi te reira i te mōrea o rangitahi whakaeke rere pūroto , me te infarction myocardial, Embolism pūkahukahu, arrhythmias. He he ano hoki te tūponotanga o te takanga o rashes mate pāwera pununga honé, ka predisposition o te manawanui ranei.

"Torasemide" ētahi wā ai whakapairuaki ruaki ranei, uaua takawaenga dyspepsia, korere. Whakaahuatia take taratahi o te pancreatitis i roto i te maimoatanga ki "torasemide". nui haere hoki transaminases ate, tohu ate tāoke o te tarukino i roto i pota tiketike. I te tahi taime hoha'a tūroro e pā ana ki waea i roto i te taringa, kite te peroo.

A, no te riro koe i te horopeta paitini i roto i te whakawhanake i te āhua o te tuwhena rawa ki ngā tohu iti. tahi tuwhena rawa e te mate o te wai i roto i te mimi: diuresis roa, me te auau, kia whakawhanake hypotension, tiango iaia, kaihapai, patu, ischemia kaka i roto i te papamuri.

Contraindications me whāititanga o te tono

e kore e taea te whakamahi Drug "Torasemide" analogues me taero whānui i roto i te aroaro o contraindications pūmau. Ko te urupare kë ki te tarukino hononga ranei enei. "Torasemide" riria ki te whakamahi i roto i te mate täkihi ki anuria, kore ate i roto i te āhua o te coma ate, me tachyarrhythmias. horomanga Contraindicated i roto i te hohipera, me te hapū, me te i raro i te tau o te 18 tau, hypersensitivity ki sulfonamides.

Te taha me ngā pānga ngā "torasemide"

I roto i te maimoatanga o pire takawhita "Torasemide" taea whai i te pānga kino i runga i te akoranga o te kauti. Mai te tubules proximal o te taonga kaha waepuha ingested e waka kaha, i reira he inhibition whakataetae o te excretion o mua. Ki te whakamārama o te whakamahi o "torasemide" tūponotanga tiketike o te hyperuricemia me kauti whakapeka.

Medicament "Torasemide" āhuatanga e te mahi motuhake i runga i te wahi proximal o koropiko epithelium tubular o Henle. Nā ki te kaha diuretic pānga me kawehiko tāne i ai te tūponotanga o taunekeneke pharmacological hauora nui tenei. He mōrearea, iti, me te e minaminatia ratou. I roto i te kino, me te nui e:

• horopeta teitei (50 mg / ra) "torasemide" ka whakamahia i roto i te taha ki te teuteu konukawata whakarei ake te tāoke o te muri;
• pota nui "torasemide" (50 mg / ra) ake i ngā pānga nephrotoxic me ototoxic o paturopi aminoglycoside;
• i roto i te paturopi cephalosporin, ka whakamahia tahi me "torasemide" i roto i te horopeta o 50 mg / ra puta nephrotoxicity rawa;
• salicylates tahi me "torasemide" (50 mg / ra) te āhuatanga neurotoxicity.
• "Torasemide" ki te whakamārama o te hypokalemia whanaunga faarahi te susceptibility o te myocardium ki glycosides cardiac, te whakanui ake i to ratou inotropic me pānga antiarrhythmic, te whakanui ake i te mōrea o te tāoke;
• nui haere te mōrea o te hypokalemia e whakamahi te rere "torasemide" ki corticosteroids laxatives saline ranei;
• "Torasemide" whakarei ake te pānga o relaxants "theophylline" curariform me te uaua.

pānga e hiahiatia ana o te whakamahi ngā

O nga pānga e hiahiatia ana e rapua e aroturuki, ko te hekenga i roto i te pēhanga toto i roto i te maimoatanga ki inhibitors ACE. "Torasemide" e tika ana ki te tango o wai te whakaiti te pēhanga hydrostatic o te toto ki te takawaenga i te maturuturunga iho i roto i te pēhanga toto. He nui i roto i te maimoatanga o te takawhita tenei āhuatanga, me te titau te ako o te horopeta o inhibitors ACE. Ano, i roto i te maimoatanga o te takawhita therapy-ātete, me te huinga o te "torasemide" ACE inhibitor taea tatou ki te whakatutuki i te māori o te pēhanga toto i roto i te 90% o tūroro.

I roto i te maimoatanga o te kore ngakau ma'i he pānga hauora nui o te whakaiti i te mahi vasoconstrictor o catecholamines. Heart i runga i te therapy diuretic papamuri "torasemide" tali ngoikore ki te stimulatory tohu Adrenaline me noradrenaline. Heoi, ko te taua pānga o te whakaiti i te whai huatanga o te epinephrine me norepinephrine i roto i whakaora.

pānga tōraro o te pāhekoheko

He pānga inhibition miramira ka ngā ki etahi matū. I roto i te ngā:

• whakatakataka o sequestrants waikawa ate whakaiti hopu "torasemide" o whēkau, ngoikore te pānga o te muri;
• Pë whakapōauau (NSAIDS) whakaiti i te whai huatanga o "torasemide";
• "Probenecid" e tika ana ki ngā tukanga amplification urikozuricheskih inhibits kōwhiringa "torasemide" i roto i te lumen o nga tubules, whakaiti tona whai huatanga.

āhuatanga whakataurite "torasemide"

I te tarukino e taea "Torasemide" analogs kia piha, nekeneke me arowhānui. I roto i te piha haapiiraa māngai analogues: "Furosemide", "bumetanide," "waikawa ethacrynic". I roto i te rite ki "Furosemide" "Torasemide" āhuatanga e te huaki puhoi o mahi me te pānga atu auroa fakafekau'aki ki nui haere diuresis. Whakarato pānga diuretic ko tata te kaha ano rite taua o "Furosemide" "Torasemide" He pānga taha iti e pā ana ki te tāne i kawehiko tere.

"Bumetanide" āhuatanga e te taonga diuretic ara kaha e pā e te ki he maha ngā pānga taha. waikawa Ethacrynic he pānga auau diuretic raro tīmatanga me te uaua whakamahia faaineineraa. Ko te pharmacokinetics o te tarukino "Torasemide" arotake tohunga ia ite tetahi wāhi nui. He āhuatanga o "fakaakeake" te raau: diuresis i muri amplification mā te tohatoha konutai kahore e vai tona pupuri.

analogues Pharmacokinetic "torasemide"

Ko te "Torasemide" aratohu rongoā whakarato pārongo i runga i tona tono i roto i te tūroro ki te matua takawhita. Āpiti atu ki te tarukino, mo te maimoatanga o te takawhita e whakamahia hoki Diuretics pāhare pāporo-tohu me te thiazide. Na thiazide tika āta haere mai me te pānga diuretic roa ko nga raau taero o te whiriwhiri.

I roto i te hononga ki enei pharmacokinetic ngā analogues mo te faaineineraa "Torasemide" tono kia te whai ake: te maimoatanga o te takawhita, ātete ki te therapy paerewa ki ngā ACE inhibitor (ranei pūārai receptor angiotensin) ki te thiazide. Hoki, "Torasemide" whakamahia i roto i ma'i maimoatanga täkihi ki te kaha filtration iti.

torasemide arowhānui ' "

I roto i te faaineineraa "Torasemide" ā-ako, analogues, tohu me contraindications tohu tino ona pānga matua - nui haere diuresis. Ano, taua mahi kua i te tarukino taketake, me te whānui. Kei roto i te whakamutunga nga taua maha o "torasemide", engari whakaputaina i raro i te tahi atu ingoa waitohu.

Ko te rongonui tino e: "Britomar", "Diuver", "Sandoz Torasemide", "Trifas", "Torcida", "Trigrim". I roto i whānui whakamātautau o āpiha pharmacological kitea nui ngā rerekētanga i waenganui i a ratou i roto i Russia. Ia o nga formulations runga ake whakakapi tino te tahi atu o ratou.

āhuatanga ohaoha o te maimoatanga "torasemide"

I roto i te maimoatanga o te takawhita, ina e whai hua ana i roto i ngā ki te Diuretics thiazide inhibitors ACE (ARBs ranei), e taea te whakahaere maimoatanga tarukino "Torasemide": tohutohu mō te whakamahi Tohe horopeta kotahi i roto i te ra. Ko te utu marama o te maimoatanga he e pā ana ki 400 moni i te utu o 60 papa o te tarukino e pā ana ki 760-800 moni. No te whakarite, te utu ā-marama o te maimoatanga "Furosemide" uaua nui 20 moni. Ko te whakamutunga mō te maimoatanga tonu o takawhita ko o iti whakamahi.

I roto i te kore te ngakau ma'i ki edema o e rua utu porowhita tohanga o ia marama maimoatanga "Furosemide" Ko e pā ana ki 20-30 moni. I roto i te faaineineraa "Torasemide" utu he 10-15 ngā wā nui. Ko te whakamutunga he pānga ngawari, e ko wenewene faarahi te excretion o mimi i roto i nga haora tuatahi o te fariiraa. Ko te "Furosemide" āhuatanga o te whakamuri: reira nui ake te nui o te mimi i roto i te haora tuatahi e rua ki te paruparu āta o te putanga mimi.

Ka rite ki te hua, tūroro employable ki takawhita ranei ma'i iti hoki tākihi ranei circulatory āhua tono "Torasemide" ako (tona utu tohua i runga ake) i runga i te tono e kei roto ngā mōhiohio e pā ana ki te whakarei ake i nui o diuresis i te wa tuatahi o te fariiraa. Heoi, ko te whakatā tau o tūroro i roto i te ngaro o te hiahia ki te haere mai ki te mahi, ko te tata kotiti tere mimi putanga. e kore e hanga te reira i te mau fifi, a na reira ka taea ki a koe ia farii i te orotahi te piha haapiiraa cheap - "Furosemide".