Glycosides cardiac. He aha te mea te reira?

He rite i roto i te hanganga matū ki te glycosides cardiac waikawa ate, cortisone, huaora, hormones, cholesterol. Enei matū he metabolites tūturu e mau tonu te mahi noa o te ngakau.

E tito glycosides cardiac o glucone (huka) me aglycone. Te reira i aglycone Ko te whakatau o te raau taero i roto i te mahi pharmacological. Whakauru ki te tauhohenga ki ētahi atu matū kaha whakarite hamanga mowhiti rima-membered i roto i to ratou hanganga.

E tohaina glycosides cardiac o te kopa me okana kāore. Ngā ratou mahi - te myocardium, e piki% 10 anake o te waihanga, whakaritea he atu 50% i roto i te uaua striated te wahi e kore e meinga tetahi pānga.

Hoki te roanga o te mahi o glycosides cardiac e wehea ki:

- roa - digitoxin,

- waenganui - digoxin

- poto - strofantin, Korglikon.

glycosides cardiac: tikanga o te mahi

I roto i te āhua tonu i roto i cardiomyocytes roto 30 ngā wā atu pāhare pāporo me 20 nga wa iti konutai. I era atu, i te i waho mata o te pūtau membrane ko pai whakatupato, a te ā-- i runga i te anga ke, ko tōraro. Ki runga ki excitation take membrane depolarization: konutai me te konupūmā tomo te pūtau. I roto i tenei tukanga, e kore e taea e te pāhare pāporo tika na waenganui i te membrane pūtau. Te taenga atu ano i roto o te pūtau mai ratou, haamata tukanga repolarization. puta tenei momeniti mua noa ki te uaua hukihuki. Ko te kupu, takiuru te nui o te konupūmā whakarato pūtau whakaiti. katote pāhare pāporo toe i roto i te pūtau, he te raveraa ra o te tukanga.

glycosides cardiac hohoro te tīmatanga o te repolarization me te whakarato tukua mōrahi o cardiomyocytes pāhare pāporo. I muri i te hāora ko e tika ana ki te whakahoki mai te toenga o ngā katote i roto me waho o te pūtau (pāhare pāporo me konutai hoki e tukua). Ko ti'aturi i runga i te pūtau rāhui pūngao, takawaenga e ATP-Ase whākōkī tenei tukanga. Ko tōna pae hohe - rōpū sulfhydryl. glycosides cardiac te ārai te pae kaha, whakaiti i te mahi. arata'i tenei katoa ki te meka e noho katote konutai i roto i te pūtau, me tenei accelerates te tīmatanga o te depolarization muri. Ki te mea ka whakaiti te ihirangi o katote pāhare pāporo tino, kua pakaru te kōtuitui o creatine Phosphate, e arata'i ki whakaiti i roto i te mana o te hukihuki o te uaua cardiac.

glycosides cardiac: contraindications

contraindications Absolute hoki ratou whakamahi he: atrioventricular poraka II tohu, pakohu bradycardia, tauhohe mate pāwera ki enei taero, haurangi ratou.

Hoki contraindications whanaunga ngā: bradyarrhythmia Atrial, AV pā tohu ahau, syndrome pakohu mate, manawa toto pūroto, pakohu bradycardia, takawhita, ngakau, hypercalcemia, hypokalemia, tākihi ranei kore pūkahukahu i roto i te hītori.

Ko reira tika ki te whakamahi i glycosides cardiac i raro i te tikanga e whai ake nei: amyloidosis cardiac, diastolic kikī rōrahi cardiac ki iti hoki te pūtahi o, thyrotoxicosis, whakapeka infarction myocardial, cardiomyopathy, pericarditis constrictive, kore ngakau congestive i te pupuri putanga cardiac tiketike, anemia, me te pera i runga i.

Tika ratou contraindications tika ki te ngaro o te pōrearea systolic, e whakamārama te koretake o nga glycosides cardiac. Na, mo te tauira, i roto i te whanaketanga o te infarction myocardial whakapeka, whakamahi taea whakapataritari whanaketanga o arrhythmias, e homai he waitohunga rawakore mo te ora atu o te manawanui.

I mua i te tono o glycosides cardiac kia kōrero ki te mātanga. Tenei ka āwhina ki te ārai i te whanaketanga o pōauautanga nui.