Macrolides - paturopi / āhuatanga General me te tono

Macrolides - paturopi, te hanganga o nei whakakitea te mowhiti lactone macrocyclic. Ratou i runga i te maha o ngā ngota waro wehea e 14-membered (clarithromycin, roxithromycin, erythromycin), 15-membered (azithromycin), he 16-membered (josamycin, midecamycin, spiramycin) rānei. He tino kaha ki pirinoa intracellular (chlamydia, mycoplasma, Legionella, Campylobacter) me cocci Gram-pai (pene, piogenez) enei matū. Macrolides - paturopi no ki te iti rawa pūhui paitini.

Maoro i reira kua he hua o te ātete koiora ki te mahi o tenei piha o taero. E whakaatu ana taunakitanga Scientific e i roto i ētahi wā macrolides 16-membered (midecamycin, josamycin, spiramycin) pupuri mahi ki streptococci pyogenic me pneumococci, ātete ki te 14-membered (clarithromycin, roxithromycin, erythromycin), me 15-membered (azithromycin) māngai rongoā. Macrolides - raau taero e mahi i runga i te diphtheria me te pertussis, Legionella, Campylobacter, Moraxella, Listeria, Chlamydia, spirochetes, mycoplasmas, ureplazmu. Me kï reira e microorganisms no ki te whānau Pseudomonas me Enterobakteriatsea whai ātete tūturu ki macrolides katoa.

tikanga o te mahi

Drugs i roto i tenei rōpū takahi ana te biosynthesis o pūmua i runga i ribosomes o ngā pūtau koiora. Macrolides - paturopi, e whakaatu i te pānga bacteriostatic. A, no te faaue pota mōrahi whakaatu mahi bactericidal ki pneumococcus, diphtheria me te pertussis. kia hoki whakaatu ēnei taero pānga immunomodulatory me anti-inflammatory.

E ngā riro enei taero i roto i te wahi Gastro-intestinal, i runga i to ratou pānga adsorption o te taonga kukū bioactive i roto i te faaineineraa, te puka inenga, me te te aroaro o te kai, me tona nui. Kai tino whakaiti te bioavailability o erythromycin, azithromycin, roxithromycin me medikamitsina, ki tata kahore pānga i runga i te bioavailability o te spiramycin, josamycin me clarithromycin.

Macrolides - paturopi, tona kukū i roto i te wē , ko te nui raro whakaritea ki papanga. Na reira e huaina hoki ratou paturopi kiko. he whakatupuranga hou o macrolides ngāwari herea ki pūmua wē. Ko te tohu teitei o te wē pūmua kohao kitea ki rodomiksinom (90%), te raro - ki spiramycin (iti iho i te 20%). E tino pai te tohaina taero macrolide puta noa i te tinana, te hanga i te kukū mōrahi i roto i ngā whēkau me te kopa. Ka taea e ngāwari ratou tomo i roto i te membrane pūtau, te hanga i te whakaeminga intracellular haurokuroku.

ahu te nuinga hua pūkoro tinana i te ate ki, me te mimi. I muri i taea te whakamahi o paturopi whai pānga taha rite ānini, whakapairuaki, ruaki, korere, ngoikore whānui, ahuatanga, mate pāwera. ka mea paturopi whakahaere rōpū ki ngā mate hopuhopu o te runga (pakohu kakā whakapeka, tonzillofaringit streptococcal) me raro (kakā mohiotia, Bronchitis) airway, pertussis, diphtheria, pakewakewa, chlamydia, lymphogranuloma venereum, periostitis, periodontitis, hakihaki nui, kampilobakterioznom köpiro, toxoplasmosis cryptosporidiosis.

Ko reira houhou ki te whakahau enei paturopi i roto i te hapūtanga. Pūtaiao kï pānga kino o te clarithromycin i runga i te kukune. Josamycin, spiramycin me te erythromycin kahore e whai i te pānga kino i runga i te kukune, kia taea te whakamahi ratou ara i roto i te hapūtanga. whakamahia Azithromycin i te wa i roto i te take o te ohotata. Te nuinga o te tarukino-macrolide tomo waiu o te whaea. I roto i te wā o te whāngai ū ko pai ki te pehi i te whakamahi o ēnei paturopi.