"Lorista" (papa): tohutohu mō te whakamahi, ritenga tūturu

He taonga ki te mākete rongoā taero ki raro te pēhanga toto. I roto ia ratou Ko nga kau fa'ufa'ufono ko receptor whākōkī angiotensin.

ahua o te tarukino

Medicine "Lorista" e wātea ana i roto i te maha o ngā puka: he faaineineraa kotahi-wae "Lorista" puka ngā "Lorista H" me "Lorista Nd" e rerekē inenga matū kaha. puka Bicomponent o te faaineineraa i mahi antihypertensive me riro pānga diuretic.

hanganga

E wātea ana i roto i te toru toketaá o te ihirangi o te taonga kaha losartan pāhare pāporo 12.5 mg, 25 mg, 50 mg papa "Lorista" monocomponent waihanga. Ka rite ki wāhanga ngaahi houalotú whakamahia me pregelatinized witi māngaro, microcrystalline cellulose, he ranunga o te reihuka me cellulose, aerosil, konupora stearate. pota kiriata paninga o te 25 mg 50 mg o pāhare pāporo losartan ranei ngā o hypromellose, talc, propylene glycol, Titanium hauhā, ka whakamahia he horopeta o 12.5 mg te tae quinoline atu kōwhai.

Papa taka "Lorista H" me "Lorista Nd" ngā o te matua me te anga. Ko te matua Kei rua ngā wāhanga kaha: Losartan pāhare pāporo 50 mg (mo te puka H) me 100 mg (mō ngā puka Nd) me hydrochlorothiazide 12.5 mg (mō "N" puka) me te 25 mg (mō "Nd" āhua). Ki te hanga i te whakamahi matua wae atu rite māngaro pregelatinized, microcrystalline cellulose, reihuka, konupora stearate.

Papa "Lorista H" me "Lorista Nd" kiriata paninga arā, o hypromellose, macrogol 4000, tae kōwhai quinoline, Titanium hāorarua me te talc.

Ka rite ki mahi tarukino

Ngā kaihoko antihypertensive ( "Lorista" teuteu) mo ā-whakaahua ana te mahi pharmacological o ia wae kaha.

Ko tētahi o te kaha kai ko losartan, mahi rite he whiriwhiri enemi o angiotensin pūmua whākōkī momo 2 receptors nonprotein hanganga.

Akoranga whakahaere i roto i te vitro me i kararehe, i kitea e hāngai ana te pānga o te losartan me tona metabolite carboxyl te i te ārai i te pānga o te angiotensin ki momo angiotensin 1 receptors. Tenei whakahohe i te renin i roto i toto wē me pūtake he whakaiti i roto i aldosterone kukū reira i roto i te toto serum.

Meinga taumata teitei o te momo angiotensin 2 receptors losartan whakahohetia tenei whākōkī, i kore e te wa taua huri i te mahi o te momo paru 2 kininazy whai wāhi i roto i te pākia o bradykinin.

Ko te mahi o te kaha kai o te takanga "Lorista" e hāngai ana ki te whakaiti i te katoa piringa parenga o te iaia moenga, te pēhanga i roto i te oko a te pūkahukahu tohanga, afterload, mo te whakarato o te diuretic pānga.

Losartan ārai te ara o te hua pathological i roto i te uaua ngakau, faarahi ātete ki te mahi ā-tinana o te tinana tangata, i roto i nei i reira he kore ngakau ma'i.

tono Daily o te horopeta kotahi o te losartan meinga he heke haere i roto i te runga (systolic) me raro pēhanga (diastolic) toto. Puta noa i te ra i raro i te mana o te taonga, ko te mana ōrite o te pēhanga toto, me te hāngai faaururaa antihypertensive ki te manawataki circadian tūturu. Whakaiti i te pēhanga i te wa o te katinga mahi inenga losartan puta i 80% whakaritea ki te mahi tihi o te whakauru kaha. I roto i te maimoatanga e kore e pāngia i te medicament i runga i te auau ngakau, me i te whakamutunga o te fariiraa e kore e whakawhanake tohu o withdrawal o te tarukino. Ko te whai huatanga o losartan te tono ki te tane, he wahine tinana o katoa ake.

Ko te wahi o nga tikanga ngā o te mahi o te hydrochlorothiazide rite te diuretic, he thiazide e pā ana ki absorption waimaero o katote māota, konutai, konupora, pāhare pāporo, me te wai kei roto i te mimi tuatahi hoki ki te wē toto o te waepuha distal tākihi. Ko te taonga whakatairanga pupuri o te konupūmā katote me mua. whakaatu Hydrochlorothiazide āhuatanga antihypertensive tika ki te roha o te arterioles. tīmata pānga diuretic i muri i 60-120 meneti, me te pumau te pānga diuretic mōrahi i 6 ki te 12 haora. Arotau pānga antihypertensive o te maimoatanga tarukino puta i roto i te 1 marama.

He aha te tono

Drug "Lorista" papa, taunaki ako ā-ringa:

• mo te maimoatanga o te takawhita, i nei whakakitea te maimoatanga ngā te;
• ki te whakaiti i te tūponotanga o mate o te pūnaha Cardiovascular me te maha o ngā matenga i roto i te takawhita me huringa pathological i roto i te ana roro maui.

dosing

tikanga tenei tarukino te mo te whakahaere-waha. Kai te kai e kore pānga i runga i te mahi o te tarukino. kia kia ngā pire "Lorista" pēhanga ki antihypertensives. Kai te kai e kore pānga i runga i te mahi o te tarukino.

I roto i te faaineineraa "Lorista" (papa) tohutohu mō te whakamahi ko te tūtohutanga dosing kotahi-wae āhua, "H", me te "Nd" ngā. Hoki ngā momo katoa medicament horopeta tuatahi, me te tiaki i te pēhanga teitei rite te 1 1 papa kotahi te ra. Ko te mōrahi pānga o te pēhanga heke ko i kitea ai i muri 3 wiki o te maimoatanga. Hei whakatutuki i te pānga nui, tukua ki te whakapiki ake i te horopeta ia "Lorista H" ki 2 papa ia 1 fariiraa. Ko te tau mōrahi o haora nga papa inenga 50 / 12.5 mg o 2 nga wahi.

Ki te he ngaro te pānga haumanu tika o te tango i te medicament "Lorista H", te kaitūtohu "Lorista Nd" papa. i runga i te aratohu taputapu ngā pārongo e pā ana ki te tau mōrahi inenga nui (100/25 mg) ia ra, e kore te mea nei i neke atu i te 1 papa.

Na roto i te whakaiti i te rōrahi o te toto komuhumuhu i roto i te oko i roto i te maimoatanga ki pota tiketike o Diuretics tuatahi horopeta ia rā o te 25mg losartan whakamahia i te wā. Na reira, ko te taea te therapy taua o raau taero antihypertensive i muri anake i te whakakorenga o Diuretics me māori o te rōrahi toto.

I roto i te faaineineraa "Lorista" e kore e (papa) ako i roto i ngā mōhiohio e pā ana ki te hiahia ki te whakatika i te horopeta mō ngā tūroro paari me iwi pangia tātari toto, he mate täkihi ki te whakawātea creatinine o 30 ki te 50 ml ia meneti ranei.

Ki te whakaiti i te mōrea o te pūnaha manawa-iaia me te maha o ngā matenga i roto i te tūroro ki te matua takawhita me huringa pathological i roto i te ana roro maui o te horopeta tīmatanga paerewa o te losartan ia whakahaere i te 50 mg ia horopeta kotahi. Ki te kahore i tutuki nga hua e tukupu ana pēhanga toto i te inenga tuatahi kia nui haere ki te 100 mg losartan, i te mea ka taea, ka whakamahi i 2 "H Lorista" faaineineraa o papa pire ranei 1 "Lorista Nd" ia ra i roto i te kotahi wahi.

pānga taha

etahi taea tūroro e pānga houhou i te maimoatanga rite kaihoko hypotensive. A, no te whakamahi i "Lorista" faaineineraa (papa) te whakamahi i ako ngā he rārangi o ngā pānga taha e pā ana ki te pūnaha rerekē o te rauropi.

Pānga i runga i te pūnaha io pokapū whakakitea e ānini, whanoke pūnahanaha, me te kore-nahanaha, ohoroa, te rohirohi, migraine.

A, no te te pānga i runga i te pūnaha Cardiovascular o te tarukino ai te orthostatic hypotension, palpitations, tachycardia, mumura iaia e pā ana-horopeta.

Mahi i runga i te pūnaha romahā puta mare, he mate i roto i te wahi romahā o runga, pharyngitis, pupuhi o te mucosa nasal.

Kei te kokotikore te pūnaha kūnatu i te puka o te korere, dyspepsia, whakapairuaki, ruaki, te mamae puku, kakā, mahi ate rerekē, ka ki te huri i te mahi o whākōkī ate me te bilirubin.

I runga i te pūnaha musculoskeletal o te mahi whakakitea myalgia, mamae i roto i te hoki, arthralgia.

I runga i nga okana toto-hanga whakaawe anemia whakakitea me te purapura.

Huri me taiwhanga tawhā, āhuatanga e hyperkalemia, nui haere taumata o pūtoto, creatinine, hematocrit, Urea i roto i te wē toto.

Ka taea te haere tahi te mahi i mate pāwera, urticaria whakakitea, pruritus, ru anaphylactic, angioneurotic edema o te mata, kaki, kātua me ngā wāhanga o runga o te whekau piringa.

contraindications

E kore e taea te tukinotia katoa i te tarukino "Lorista". kahore e tohutohu mō te whakamahi tohutohu ki te tono i te taputapu i whakahuatia anuria tākihi tangata ka creatinine whakawātea iti iho i te 30 mL ia meneti.

Contraindicated fariiraa ki hyperkalemia, hypokalemia whakangutungutu, takahi o te toenga wai i roto i te tinana i roto i therapy ki pota tiketike o Diuretics faaite maumaui o te ate, te pēhanga mā'olunga, kaimahi o te lactase paru, ātete ki te kūhuka me galactose, hapūtanga, ū, tamariki me taiohi i raro i te 18 tau o te tau .

Maimoatanga ki "Lorista" (papa) ako opani hypersensitivity ki pūhui sulfonamide o te raupapa, ki te taonga losartan, hydrochlorothiazide wāhanga pŭpŭ tauturu ranei medicament.

hiahiatia tūpato te ka whakamahia i roto i te tūroro ki te waimaero toenga wai-kawehiko i roto i te toto, ka i reira he tohu alkalosis hypochloremic, ihirangi iti o katote konutai, pāhare pāporo, konupora me nohanga tiketike o ngā katote konupūmā i roto i te tinana tangata.

constriction më o iatuku tākihi whāiti o te iatuku ki te tākihi kotahi, mate huka, taumata faateiteihia o mua i roto i te wē toto, waipara o urate i roto i nga hononga ranei, te aroaro i roto i te mate pāwera mua ki taero e tautāwhi i angiotensin tahuri whākōkī, huangō arahau, ko nga mate pūnaha toto te take ki tupato whakamahi o te rongoā antihypertensive.

Āhuatanga o te tono

I roto i te maimoatanga "Lorista" (papa) tohutohu mō te whakamahi anō ka taea te tango atu antihypertensives. e kore hoki te iwi pakeke ko te whiriwhiri motuhake o te inenga tuatahi e hiahiatia ana.

O te tarukino kia arahi ki nui haere nohanga o creatinine me te tiomimi i roto i te serum o tūroro toto e kua i te stenosis më o te iatuku tākihi ranei stenosis o te iatuku o tetahi tākihi.

I raro i te mana o te hydrochlorothiazide faarahi ho'ii hypotension, toenga kawehiko ohorere, āhuatanga nei i te he hekenga i roto i komuhumuhu rōrahi toto, hyponatremia, alkalosis gipohloremichesky, hypomagnesemia, hypokalemia. Kei te whakahaua Pānga o diuretic ki te whakanui ake i te kukū o te cholesterol me pāhare, rerekētanga kātakí o te rauropi ki te kūhuka rāpoi ngota, heke excretion o te konupūmā i mimi, e ai ki a ratou ake i roto i te serum. Ka taea e Hydrochlorothiazide meinga hyperuricemia me te kauti.

I roto i te hanganga o te ngā takanga kei reihuka, i ko contraindicated i roto i ngā tūroro mauiui i kore o te pūmua whākōkī lactase ka galactosemia ranei te kūhuka ātete syndrome me galactose.

I roto i te wāhanga tuatahi o te maimoatanga o taero antihypertensive kia whakaiti i te pēhanga me karakia āmai, e whakaiti i te mahi psycho-tinana o te tinana. Na reira, tūroro nei mahi e hono ki nui haere whakarongo i te whakahaere o te huarahi matatini ranei huarahi, kia whakatau ratou huru i mua i te nganatanga ki te mahi i to ratou mau ohipa.

analogs

JSC "Krka, dd, Novo mesto" ko te kaihanga o te tarukino antihypertensive "Lorista" (papa). Analogs o te taputapu i roto i te hanganga i te kaha pāhare pāporo taonga losartan. Hoki ngā puka ngā medicaments ōrite Kei roto e rua ngā wāhanga kaha: pāhare pāporo losartan me hydrochlorothiazide.

Hoki te faaineineraa "Lorista" tairitenga ka whai i te pānga antihypertensive taua me ngā pānga taha rite. Ko tētahi taua tikanga ko te medicament "Cozaar" papa o 50 mg 100 lozertana pāhare pāporo ranei. Ko te kaiwhakanao ko te pakanga "Merck Sharp & Dohme BV" i roto i te Netherlands.

Hoki ngā puka ngā o orotahi ko "Gizaar" me "forte Gizaar." Ko te kaihanga He te "Merck koi & Dohme BV" i roto i te Netherlands. Papa pani medicament i te porotītaha anga kōwhai inenga tohua ki "717" ki runga ki tetahi o nga papa, me nga tūponotanga mō te wehenga i te atu taha, ka pani papa porotītaha inenga rahi ma kiriata-pani ki te ti'araa "745" i tetahi taha.

Ko te hanganga o te tarukino "Gizaar forte" ko losartan pāhare pāporo 100 mg me hydrochlorothiazide, e kei te 12.5 mg. Ko te faaineineraa "Gizaar" he pāhare pāporo losartan i roto i te nui o 50 mg, me hydrochlorothiazide, i roto 12.5 mg.

Haunga te tarukino "Lorista Nd" medicament "Gizaar forte" kei te hawhe o te hydrochlorothiazide me te konurehu lozertana wāhi. E rua raau taero i anti-hypertensive pānga o paku diuretic pānga.

Ko tētahi atu tairitenga Ko te tarukino ngā "Lozap me" hanga "Zentiva AS", Czech Republic. Kei te whakaputaina te reira i roto i te puka o papa tapawhā ki Valium i runga i rua papa pani ki te kiriata kōwhai marama. Ko te hanganga o te medicament he pāhare pāporo losartan i roto i te nui o 50 mg, me hydrochlorothiazide, i roto 12.5 mg.

Waihoki tarukino mō "Lorista H" Ko te tarukino "Vazotenz H" hanga "Aktavis rōpū aa", Tiorangi. Wātea i roto i te rua toketaá. I roto i te papa, kei te horopeta iti 50 mg pāhare pāporo losartan me hydrochlorothiazide 12.5 mg, me papa ki te inenga rahi kei 100 mg o pāhare pāporo losartan me 25 mg hydrochlorothiazide.

Reviews

Drug "Lorista" riro ngā arotake. Ētahi tūroro kite whakapai ake i roto i nga wāhanga tuatahi o te maimoatanga, ka te heke kitea i roto i te pēhanga toto. Etahi mōhio he hua i roto i te pēhanga toto i roto i te ahiahi i te ngaru o te kare ranei. I roto i te take i taua he mea e tika ana ki te whakakore maimoatanga tarukino "Lorista" (papa). Tohutohu Mua fakatahai wāhanga "taha Pānga", e whakaatu ana i nga ngā taea katoa kino i i tuhia i roto i te whakamahi o te kaihoko antihypertensive.

Drug "Lorista" tango i tenei ra, te whakamahi i te inenga iti e faarahi i runga i te wā e tika ana ki te Habituation o te kaiao ki te taonga kaha. E kore te mea tonu te pānga maimoatanga, engari te haaputuputuraa o te raau taero i roto i te tinana.