Te immunoglobulin G, he aha te mea te reira mo te tangata?

Hoki whawhai mate i roto i te tinana tangata hāngai ki te maha o ngā āhuatanga. Ko tētahi o nga wahi tino nui i roto i tenei tukanga no ki te immunoglobulin, ranei ki te kia pau ake, te immunoglobulin G. Ētahi momo o immunoglobulins, i taea ki te tiaki i te tinana o te tamaiti hou i mate IG G, rite te kaha ki te tomo ki te toto o te whaea i roto i te ewe, tomo i te bloodstream o tamaiti.

Kei te rāpoi ngota o IG G subunit, tona taimaha ko e pā ana ki 150 KD. I roto i te tangata, me te i roto i kiore, whakaahuatia wha subclasses, e immunoglobulin nei G. i tuatahi kitea ratou e tikanga serological. Immunoglobulin hinere rohe āhuatanga e te maha nui o ngā toenga cysteine me te rāpoi ngota proline, e whakatau tona ngāwari. Disulfide here i roto i tenei wahi o te rāpoi ngota i ratou rerekētanga, e hāngai ana i runga i te globulin sublcass. Ko te kupu, gamma 1 me te kama globulins 4 E rua here disulfide, gamma 2 - wha Gamma 3 - tahi. Taketake mai te gamma 1 mekameka kopi rohe anake i te toenga 216-th me mutu ki 231-m. He rohe kopi Gamma mekameka 3 kei runga e wha tekau whitu toenga i muri atu i te 1. Ako Gamma waikawa raupapa amino homai hanga taea reira ki te amo i taua te hua rite i roto i ngā toenga e pā ana ki ngā wāhi tāruarua rua 216-231 gamma 1 mekameka. Ko te rohe kopi kua he singularity faufaa: taunekeneke i roto i te mekameka taimaha e rua puta me te hanganga octapeptide huringa mārō, e te kaimahi rite tuaka hurihanga mo te rohe kopi ngāwari katoa, a konei mo Fab-whatiwhatinga e te hunga e tika ana ki te taunekeneke ki te plurality o antigens.

puta waihanga IG G i roto i te whakautu ārai tuatahi, me te tuarua, ka rite ki tenei momo o te antibody te tino tōtika tomo ki te kikokiko, herea reira ki a muri tango antigens ke.

Hoki te tiaki antibacterial i roto i te tinana tangata pahono rite immunoglobulin Whakatairangatia G. tenei momo o te globulin pea i roto i te wā i reira te pūnaha ārai mate kua tae kē ki te whakapā ki antigens ke a ka anga tona production kaha o paturopi. Ko te kupu, ko te hua kitea i roto i te maha o immunoglobulins wā e taea te tīmata tātaritanga wā me te maimoatanga o te mate e meinga he momo o te huakita me te huaketo.

Ko te mahi matua o tenei momo immunoglobulin ko te tiaki o te tinana tangata i āpiha ke ahei o meinga mate hopuhopu. Immunoglobulin G rite te tukumate whawhai ki a ratou, me te ki nga hua o to ratou pūkoro tinana mā te opsonization, ngā pūnaha phagocytosis whakarewatanga me te haapoupouraa.

Immunoglobulin G Ko te thymus-ti'aturi, synthesized e te roto i te thymus (thymus), me te whai wāhi tika o T-lymphocytes. Tenei momo globulin ko te wāhanga matua, me te hautanga globulin o toto ko e pā ana ki 80% o ngā momo katoa o immunoglobulins. Ko te kupu, ko te fariiraa o ngā immunosuppressants, me te te rongo i roto i te tūranga e kore noa ki te pehi i te ariā o IG G, engari ano ki te pehi i te reira tino.

Te immunoglobulin G, i te mea te täkupu i roto i te tinana rerekē i runga i te tau ki te 15 tau tae tona taumata whakamutunga, me te he 8-17 karamu ia rita o te toto. I roto i tenei take, e taea ana ki te kia e kore anake i roto i te bloodstream me porotītiti puta noa i te tinana me te toto, ratou e taea hoki ngāwari tomo ki te wāhi extravascular, mai te raveraa i katoa o ona mahi maha nga immunoglobulins. Kei te kaupae tohaina immunoglobulin G e rua i roto i te bloodstream me ētahi atu te kopa i roto i te tinana, reira whakarato tiaki o te rauropi ki te mate.