Ko te tarukino "Leykostim": tohutohu mō te whakamahi, ritenga tūturu

He aha te mea te tarukino "Leykostim"? Ka Tohutohu, puka tuku, tohu me contraindications ki tenei tarukino kia whakaahuatia i raro nei. korero hoki matou ki a koutou e pā ana ki te mea e wātea ana analogs mō ngā tenei taputapu i roto i tona hanganga, a na i runga i.

Te āhua, tākai, wahi o te tarukino

He ahua aha e te tarukino "Leykostim"? Tohutohu mō te whakamahi pūrongo e hangaia medicament kaha te rite te otinga mō te whakahaere subcutaneous rō-uaua ranei.

He filgrastim te wāhanga kaha o te kaihoko. Ko te take koroni-whakaongaonga granulocyte recombinant. kia roto i 1 ml o te otinga tarukino 300 mg (30 miriona. Iu), 600 mg (60 miriona. Iu) ranei 150 micrograms (15 miriona. I.U.) filgrastim.

Ka rite ki mo nga excipients, na ratou te whakamahi rite mannitol, konutai tāpia trihydrate, dextran, waikawameha ahetiki, polysorbate, me he wai mo te werohia.

I roto i te otinga te tākai hokona te "Leykostim"? Tohutohu mō te whakamahi tāmau i roto i te pouaka pepa tahi ki tetahi ranei rima oko o tarukino.

Ko te āhuatanga o te tarukino

He aha ko te huarahi o te mahi o te tarukino i roto i "Leykostim"? Tohutohu mō te whakamahi, tākuta arotake mea e ko te reira i te tarukino-immunomodulator. Ko te pūmua tino e purea kore-glycosylated e kua he mana ture i runga i te whanaketanga me te kaupapa (i te hinu wheua wheua ki te toto) neutrophils mahi.

I muri i te kupu whakataki o te tarukino tino whakanuia ana te maha o neutrophils i te toto, me te paku anake - monocytes. puta tenei i roto i te 24 haora.

Ko te hua i roto i te neutrophils toto ko horopeta-ti'aturi. Generation o pūmua kaha biologically, i.e. filgrastim, e normalizes te tini me te pārōnaki o ngā pūtau kawea e taumahatanga o te huakita Escherichia coli. Ratau, te whakamutunga, e tika ana ki te kaha o te engineering ira hou, kīnaki i te ira granulocyte koroni whakaongaonga tauwehe tangata.

E ai ki tona parau tumu o ngā pānga i runga i te tinana, ko te rite ki te take koroni-whakaongaonga granulocyte, i te mea o te take taiao te tarukino. Ko te rerekētanga anake ko nga meka e kore te "Leykostim" (otinga) glycosylated, a he toenga waikawa amino N-kāpeka o methionine.

Āhuatanga o te tarukino

He aha ngā āhuatanga e te rongoā "Leykostim"? kī Tohutohu mō te Whakamahi e kia whakamahia te reira i roto i te tātaritanga o te neutropenia i roto i te iwi e mamae hahau. Ano, Ko te tino whai hua mō te neutropenia ma'i tenei tarukino. Ko e tika ana ki te meka i he taea ki te whakahoki i te maha tino pai o neutrophils i roto i te tinana tangata ia tenei.

Mā te whakamahi i te waihanga mo te ārai, ka taea e tino te manawanui whakaiti i te pā o neutropenia, me te whakaiti i te matatini o te rere, me te wā roa o te mate. Taua te rongo ārai pōauautanga hopuhopu, heke roa manawanui o hōhipera noho, ka taea te hahau i waho ia i nga ngā e kua whakapumautia kaupapa whānui o te maimoatanga.

Ka rite ki te tinana tangata mahi "Leykostim"? Tohutohu mō te whakamahi tohu e te whakamahi o te tarukino whai wāhi ki te aronga i roto i ngā pūtau toto piringa hematopoiesis mua, i kohia e cytapheresis (i.e., wehe i te toto ki te wāhanga pūtau ki te tango whiriwhiri), me te whakahaere ki te manawanui i muri i te akoranga o tiketike-horopeta hahau.

I roto i tahuri, i te pūtau patia (kakau) he mahi hematopoietic, heke pūnaha ārai mate, me te hematopoietic, me te whakaiti i te mōrea me te pakeke o te pōauautanga hopuhopu, me te hemorrhagic.

haumaru rongoā

Ko reira haumaru mō te tarukino tangata "Leykostim"? āhua ā-e taea te whakamahi i tēnei tarukino mō rua tamariki me ngā pakeke. Ko reira rite haumaru mō ngā iwi katoa te fariiraa i te hahau cytotoxic.

Tūroro ki otinga tono ārai huaketo whakarato te taumata tino arotau o neutrophils me homai te whai wāhi ki te whai i nga toketaá tūtohutia katoa o therapy toohunga myelosuppressive ranei.

A, no te whakamahi i tenei hua o HIV tukuruatanga i kitea.

Pharmacokinetics

He aha te tarukino pharmacokinetic kua "Leykostim"? Ako tohu e te kukū o te whakauru kaha o tenei kaihoko ko tika ti'aturi i runga i te horopeta whakahaere.

I muri i whakahaere subcutaneous, te nui rahi o te tarukino i roto i nga toto kitea i muri āhua 8-15 haora.

Ko te hawhe-ora "Leykostima" rauemi kaha he toru ki te wha haora. metabolized Filgrastim ki peptides. Mō 1% o te wāhanga kaha puta tonu i roto i te mimi.

e kore e Filgrastim haaputuraa i roto i te tinana tangata puta noa whakamahi i muri roa o te tarukino (ina nui marama o te therapy). I roto i tenei wā o ona hawhe-ora ko te taua.

Tuhinga

"Leykostim" whakaritea te rongoā te mo te take e whai ake nei:

• mo te whakaiti i te roanga o te rere neutropenia kaupae 2-4, a hoki ana ki te whakaiti i te pā o te neutropenia febrile i roto i te tangata ki te pukupuku nemieloproliferativnymi i muri i te hahau ki āpiha cytostatic;
• ki te whakaiti mau faaiteraa o pōauautanga e whakatika ina neutropenia, rite pai rite mo te whakaiti i te akoranga wā o te mate i roto i te tangata pangia te hahau myeloablative ki wheua wheua hei akiaki transplantation;
• ūnga pūtau mua hematopoiesis i roto i te toto piringa mo te whakaaro o te wehe, me te te huaranga ratou i muri i te hahau myelosuppressive;
• mo te maimoatanga o te neutropenia i roto i te iwi ki a HIV mate (tae atu te hunga i roto i te wā arā atu) i roto i te tikanga ki te whakaiti i te tūponotanga o ngā mate hopuhopu o te take mai kitakita;
• mo te maimoatanga o te neutropenia ma'i;
• ngā wāhi pūtau hematopoiesis mua, i roto i te toto piringa o ngā kaituku hauora ki te kia whakatokia, ka wehea ratou mate.

contraindications

He aha e kua te tarukino contraindications "Leykostim"? korerotia ngaio Reviews te rāhui e whai ake nei:

• nui haere te tūtohutanga takitahi o te manawanui ki nga kai kaha, me te tahi atu i roto i te hanganga o te tarukino;
• neutropenia congenital, nui rerengia i ki disorders cytogenetic (Kostmann syndrome);
• wā fā'ele'i (rawa te tuatahi o te ora marama).

Drug "Leykostim": ako me te tono

Ka taea te whakahaere rongoā tirohia i roto i ara e rua:

• pâmuhia;
• subcutaneously.

kia inenga me te tikanga o te whakahaere "Leykostima" kia whakaritea e te tohunga, i runga i te āhuatanga haumanu, te āhuatanga takitahi o te manawanui, me te mate rānei. Heoi, kia tuhia te reira e te mahi hauora reira meinga te whakahaere subcutaneous o te tarukino.

Hoki medicament kaha rō-uaua mawehe te i te pounamu i te pūwero, a ka i honoa reira ki te pounamu o te 5% terehuka. Kei te whakahaerea te otinga hua ki te manawanui mo te hawhe haora.

Me pēhea te ki te faaohipa i "Leykostim"? Tohutohu (ka e kōrero analogues o tenei rongoā i raro nei) kī e kia kaua e mua whakamahia atu te ra i muri i te mutunga o te hahau te tarukino.

whakahaere te otinga tarukino i runga i te taimaha o te manawanui rānei. Ko te awhe horopeta o 5-12 mg ia 1 kg taimaha. E whakamana werohanga i ia ra ki te auautanga o kotahi te ra.

whakaaro therapy te kia kawea te tarukino i rite te roa rite te maha o neutrophils i roto i te toto e kore e tae ngā taumata noa. Tikanga, te roanga maimoatanga he rua wiki.

I roto i whakahaere e hiahiatia ana tohunga ki te whakatau wā te maha o leukocytes i te toto. Ki te he nui atu i te 50,000 / microliter te tokomaha, hurihia te tarukino.

I roto i therapy, kia whakawhanake i te manawanui thrombocytopenia. I roto i te take i roto i assays toutou pupuri i te uara tatau mōtepe te raro 100,000 / microliter, ka tirohia te whakakorenga rangitahi o te tarukino whakaiti tona inenga ranei.

pānga taha

E ai ki ngā tatauranga, te tarukino "Leykostim" uaua ai tauhohe kino. Heoi, ka taea e whai wāhi tonu te reira ki te putanga o taua pānga rite:

• dysuria;
• mamae i roto i te wheua uaua ranei;
• alopecia;
• hepatomegaly, splenomegaly;
• hypotension (rangitahi);
• nui haere ngā taumata o mua, me te phosphatase kawakore;
• ngoikore, pāhoahoa me rohirohi;
• tauhohe mate pāwera i roto i te timatanga o te maimoatanga, i maha puta i muri i whakahaere rō-uaua o te raau taero.

Me mahara hoki käore te reira e ka ai whakakorikoria te werohanga hē te hūhi manawanui i te wāhi i werohia.

taunekeneke tarukino

I mua i te whakamahi i tenei tarukino, me feruri koe i roto i pehea ki te taunekeneke ki ētahi atu rongoa "Leykostim". Tohutohu (Inn o te rongoā tangi rite "filgrastim") Kei te kōrero oti i roto i:

• Medicament "5-Fu" haapuai neutropenia.
• No te mea e tino rauangi ki āpiha cytotoxic, ki whakarite tipu pūtau myeloid "Leykostim" kia waiho hei ra i mua i muri i te whakamahi o enei raau taero ranei.
• medicament tirohia hotokore ki te konutai pūhaumāota.
• A, no te whakamahi i te otinga ki te aronga o ngā pūtau tupuna e whai ake hahau kia whakaaro e heke te tōtika, ka te ohipa tono roopu "carmustine" "Melphalan" me "carboplatin".

tūtohutanga motuhake

E kore e tūtohu ana ki te tautapa "Leykostim" iwi ki te mahi ate waimaero me tākihi, rite haumaru filgrastim me te miramira i roto i enei tūroro kua kore i ako.

Tūroro ki osteoporosis me ētahi atu mate wheua, e whakamahi i te tarukino tonu mo e ono nga marama, kia whakahaere koe i te mana o te wheua kiato.

E kore kua te whai huatanga o te tarukino i roto i te iwi ki te nui iti o ngā pūtau tupuna myeloid kua ako. Heoi, tautohe tohunga e i roto i taua tūroro e taea e tino raro te tohu o hua i roto i te maha o neutrophils.

Miramira me te haumaru o "Leykostima" i roto i te iwi ki ma'i kanisā myeloid me syndrome myelodysplastic kua kore i whakapumautia. I roto i tenei hononga, i roto i taua mate e kore e te whakaaturia.

Monotherapy whakaaro kore tarukino ārai anemia me thrombocytopenia, e kua meinga e te hahau myelosuppressive. Kei te hiahiatia te reira ki te whakatau i te maha o platelets me hematocrit. kia faaohipahia ngā tūpato ina whakamahi i te-wae kotahi pahekotanga ranei regimens chemotherapeutic, kua mohiotia hoki ratou kaha ki te meinga thrombocytopenia kino.

I mua i tīmata maimoatanga, "Leykostimom" e tika ana ki te hanga i te tātaritanga āmiki o te toto ki te nui etahi o te mōtepe me leukocyte kaute, ka tūhura i te karyotype me wheua pikitia wheua.

I roto i te wā o te maimoatanga e hiahiatia te ki te aroturuki auau i te mimi me te rahi o te kōateate.

Drug "Leykostim": analogs me utu

E whakaaro analogues taero te raau taero e whai ake nei: "Filergim", "Grasalva", "Granogen", "Neupogen," "leucite", "Neypomaks", "Mielastra", "Neyrostim".

Ko te utu, ka "Leykostima" he tiketike rawa. Hokona tenei raau i roto i pharmacies i Moscow, a taea e te tahi atu pa Russian o 2500-4500 moni. Ko te utu o tenei rongoā tei runga i te rahi me te maha o ampoules ia mōkihi.

Reviews rongoā

Kia aroha mai, arotake o tūroro e tangohia tenei tarukino, iti rawa. E ai ki te meka i reira e, te rongoā tino maha whakaritea mo te pūnaha ārai mate, me te neutropenia huringa i roto i ngā tamariki. Ko te pānga o te tarukino i roto i taua mate nui he poto.

Me mahara hoki käore te reira e reira e mua manawanui i runga i te whakamahi haumanu o "Leykostima" i roto i ngā tamariki me ngā pakeke ki te neutropenia e pā ana ki te hahau mate pukupuku. Te faaineineraa whakaritea ngā pēpi i roto i te inenga o te 5 mg / kg ia ra, kaua pai nohotahi.

Ētahi tūroro hiahia i roto i te pātai e pā ana ki te mea he pai ahua o otinga: "Leykostim" ranei "Neupogen". Ka rite ki te hua o te mau tamataraa haumanu i i kawea atu ki te tautuhi i te tolerability me te aonga o enei āpiha, i tae te whakatau e whai ake nei: e kore e taiea kati mo te ako o te neutropenia i muri i te whakamahi i nga rongoa whakahuatia. Ano, E ratou rite te taua tohu o miramira me tolerability.