"Azathioprine": ako ā-, arotake, ngā whakaahuatanga, analogs

E karanga hoki te tarukino "Azathioprine"? ka Tohutohu i runga i te tono i tukuna e te āpiha e whakaahuatia i roto i tenei tuhinga. korero matou hoki koutou ranei reira e me contraindications analogues i tenei tarukino, he aha te utu i te reira, te mea e tupu i roto i te take o te tuwhena rawa, a na i runga i. d.

Composition, tākai, āhua, medicament whakaahuatanga

I roto i te aha puka he tarukino wātea "Azathioprine"? Tohutohu mō te whakamahi kī e he wātea i roto i te puka papa tenei rongoā. mahi ratou whakauru kaha rite azathioprine. Ano i roto i te tarukino me ngā kai atu i roto i te puka o te māngaro rīwai, gelatin, reihuka, me te konupūmā stearate.

I roto i te mōkihi hokona te tarukino "Azathioprine"? Tohutohu mō te whakamahi o te raau taero kopakia ana te roto i te pouaka pepa, i whakanohoia koma pire Valium kōwhai i roto i mōkihi namunamu o 50 nga wahi.

āhuatanga pharmacological o te medicament

He aha te mea tenei rongoa rite "Azathioprine"? Tohutohu mō te whakamahi, ngaio mātanga tūturu kī e te tarukino i roto i te pātai ko te tairitenga "hypoxanthine", "Adenine" me "guanine", ngā i roto i te hanganga o waikawa karihi, me te whakaatu i te pānga ārai e pā ana ki te tini kiko, me te wehewehenga pūtau.

"Azathioprine" - kaihoko immunosuppressive. hāngai Ko tōna mahi i cytotoxicity pūtau.

Whakaaro he tarukino taea ki te tautāwhi i te tauhohe o te kiko incompatibility me pā te tāruarua o paturopi, engari ki te whānuitanga iti anake. Ina whakaritea ki "mercaptopurine" whakaaturia tarukino hohe te korerotia atu.

tarukino Pharmacokinetic

I muri tarukino-waha te pai whenumi i te wahi gastrointestinal. He he here iti ki pūmua wē (āhua 30%).

Ko te biotransformation o te tuku tarukino puta ki te waikawa tioinozinovoy me mercaptopurine (i.e., metabolite kaha). Ko te nui iti o rongoā ki te kiko. I roto i tenei take, kitea te kukū iti o te raau taero i roto i te roro.

Ko te hawhe-ora o azathioprine, me ona metabolites kaha ko e pā ana ki 6 haora. Ko te kukū rawa o tarukino i roto i te toto kitea i muri i 70-110 meneti.

Kei te tata rawa tukua te tarukino tahi ki ate, me 1-2 anake% - i te whatukuhu.

papa Tuhinga

He aha kaitūtohu "Azathioprine" (tohutohu mo te whakamahi o te raau taero, analogs, ka kia te aroaro arotake i muri)? faaite teie faaineineraa iho tōtika ka te abnormalities e whai ake nei:

• psoriasis;
• kaikōiwi;
• whero erythematosus lupus pūnahanaha ;
• colitis ulcerative;
• dermatomyositis;
• gravis myasthenia;
• ino Pemphigus;
• periarteritis nodosa;
• mate o Crohn ;
• glomerulonephritis, autoimmune;
• kakā hohe ma'i;
• syndrome o Reiter ;
• te purapura thrombocytopenic idiopathic.

Me mahara hoki käore te reira e te maha whakaritea tenei rongoa mo te ārai o te transplant makanga. Otiia i roto i tenei take e riro te reira i roto i ngā ki ētahi atu rongoa.

Contraindications ki te whakamahi o te raau taero

Tohutohu mō te whakamahi o te tarukino "Azathioprine" ngā tūroro e pā ana ki te contraindications e whai ake nei:

• kore ate ;
• hypersensitivity ki wāhanga kaha ngaahi houalotú ranei rongoā;
• i roto i te hapū;
• te huru o te hematopoiesis tukinotia;
• tau o ngā tamariki;
• ū.

Medicament "Azathioprine": Inenga me te whakahaere

kia anake kia whakahaerea Tangohia "azathioprine" papa waha. I roto i ia take, whakaritea te horopeta o te raau taero e takitahi, i runga i te taunakitanga e wātea ana, me te te pakeke o te mate, me te therapy te rere rānei.

Hoki te ārai o te uhi makanga rongoā whakaritea i roto i ngā ki "cyclosporin" me corticosteroids. I te timatanga o te tango rongoā therapy i roto i te horopeta uta e ko 5 mg ia kg (i runga i rua marama). I muri tango rongoā i roto i te tiaki horopeta (1-4 mg ia kg i roto i te 3 pota). Tikanga, Kei te haere tonu taua maimoatanga mō te wa roa. Ki te whakakore koe tuku iho te horopeta therapy o rongoā te āta.

I takanga o nga tohu tuatahi o te pato'iraa o te okana whakatokia hiahiatia te ki ake i ano te inenga rā o medicament ki 4 mg ia kg.

Hoki te maimoatanga o ētahi atu mate medicament tikanga whakahaere i roto i te horopeta rā o 1.5-2 mg ia kg ki te 4 werohanga wehea. Ki te tika, e taea te nui haere te nui tohua o te tarukino ki 200-250 mg (wehea ki te 4 werohanga). whakaturia te roanga o te maimoatanga ki tenei taputapu te takitahi, he mātanga mātanga.

Me pēhea te ki te whakamahi i "Azathioprine" (papa) i roto i te kaikōiwi? Tohutohu mō te whakamahi, whakawākanga (i te aroaro faaineineraa whakaahuatia i runga) kī e mo te maimoatanga o taua mate i whakaritea 1-2.5 mg ia kg ia ra (wehea ki 2 werohanga). kia i te iti rawa 3 marama roanga o therapy. Ka rite ki tautoko hoatu te manawanui ko te horopeta o 0.5 mg ia kg (horopeta kotahi).

Hoki te maimoatanga o kakā B (kaha) whakahau te horopeta rā o 1-1.5 mg ia kg.

Kēhi o tuwhena rawa tarukino

He aha e nga tohu o te tuwhena rawa anoo i te fariiraa he "Azathioprine" tarukino? Tohutohu mō te whakamahi, kī tākuta mātanga tūturu e kia meinga i te horopeta teitei o te tarukino ngā āhua dyspeptic, pancytopenia, disorders o mahi ate, me te whakarei ake i te tahi atu ngā pānga taha o te tarukino.

Ka rite ki te maimoatanga o taua ari te whakamahi i therapy symptomatic. Ki te tika, tātari toto. Heoi, kia mōhio e kore e tenei tikanga te kī i te whakakorenga oti o te taonga kaha i te tinana.

taunekeneke tarukino

Ka rite ki te tahi atu raau taero pānga tarukino "Azathioprine"? Tohutohu mō te whakamahi āhua i tahi-whakahaere o te kaihoko ki "Allopurinol" taea whakarei i te pānga paitini o te tuatahi, a i roto i te taha ki te "tahi-trimoxazole" maha arata'i ki nui haere ngā pānga myelotoxic.

maimoatanga tukutahi ki inhibitors ACE whakanuia ana te mōrea o te leukopenia nui.

I roto i te i ngā ki ētahi atu immunosuppressants (hei tauira, "Cyclosporins", glucocorticoids, anti-CD3 paturopi) rawa maha i te whānuitanga o ngā neoplasms me mate.

faaineineraa i Tirohia whakaaturia pānga pato'ito'ii ki nedepolyarizuyushim relaxants uaua.

Me mahara hoki käore te reira e werohanga i roto i te maimoatanga "azathioprine" taea rawa ngāwari arahi ki te pehanga o te hanga o paturopi (i roto i te take o kano inactivated), me te whakapiki ake i te tukuruatanga viral (ki te whakataki o kano ora).

tūtohutanga motuhake

Mea ki te mohio i mua i whakahau koutou rongoā "Azathioprine"? Tohutohu mō te whakamahi, tūturu (analogues rongoā tabulahia i raro nei) kāwanatanga e i roto i nga marama e rua o te therapy tuatahi hiahiatia te wiki i ia ki te mau i te tauira o te toto piringa. I muri i tenei wa, whakaatu ana te ako te wāhanga ki te auautanga o te 1 nga ra 30.

Ko reira tika hoki ki te aroturuki i te taumata o te bilirubin, phosphatase kawakore me whākōkī ate.

I roto i te aroaro o abnormalities o tākihi ate ranei, me te te fariiraa tahi ki "Allopurinol" Me heke inenga medicament i raro i whakaaro ki te 1/4 wahi.

"Azathioprine" ki te tūpato tino whakaritea ki te hunga tūroro i roto i nei i reira he herpes zoster, koroputa hei, xanthine oxidase hē, me te wā radiation cytotoxic therapy ranei.

Analogues me te utu tarukino

He aha e taea e whakakapi "Azathioprine"? Tohutohu mō te whakamahi (te utu o nga rongoa tabulahia i raro nei) āhua e kua whakaaro he torutoru hoa te tarukino. Ko te tino rite i roto i te pānga ngā te rongoā e whai ake nei:

• "Arepa-fetoprotein."
• "Alfetin".
• "Stemokin".
• "Profetal".
• "Revlimid".

Ko te utu, na e kore te mea tiketike rawa tenei hua. 50 papa "azathioprine" i runga i toharite e pā ana ki 230 moni Russian.

Reviews o medicament

He arotake torutoru o te tarukino "Azathioprine" tikanga whakauru. Ētahi iwi tango i te rongoā hoki o te mate autoimmune, he makona ki tona rongo whai hua, me te kore o ngā pānga taha nui. Etahi, Heoi, tūroro e kore ua e tetahi hua, a na reira ua faaoti ratou ki te hoatu i to ratou hiahia ki ētahi atu tikanga.

Me kï reira e nga tohu katoa, mo te whakamahi o te tarukino "Azathioprine" kōrero ki te mate, kaua nui hoki e anake e taea e rawaka therapy he ngaio mātanga. I roto i tenei whakaaro, i roto i te take o te māharahara o te aroaro o tetahi mate i te rārangi i runga ake, me waha koe i te whakamātautau whānui rata, kihai ki whaiaro medicate-.