Ahotea oxidative: te tūranga o te huarahi, te tohu

whakaaro Stress te ki hei whakautu kore-motuhake o te tinana ki te mahi o ngā āhuatanga ā-waho ranei. I whakaurua tenei whakamāramatanga ki te mahi o H. Selye (physiologist Canadian). Tetahi mahi huru ranei e taea te whakapataritari te ahotea. Heoi, ka taea e tetahi wehewehe kotahi take, me te karanga i reira te take matua o te tinana tauhohenga.

āhuatanga

A, no te tātari i te tauhohenga he kotiti ahakoa kei te āhuatanga (ahuareka kino reira ranei) kei roto i te tinana. O moni ko te kaha o te hiahia urutaunga whakatikatika ranei i raro i te tikanga. Ko te tinana matua pāngia e te kaihoko irritating hoariri tona kaha ki te whakautu ngāwari, ka urutau ki te āhuatanga. Runga i, Ka taea e tatou te utu i te mutunga e whai ake nei. Stress Ko te whakautu urutau matatini tukuna e te tinana i roto i te take o te tauwehe pānga. huaina ana tēnei āhuatanga i roto i te pūtaiao urutaunga whānui syndrome.

atamira

puta urutaunga syndrome i roto i ngā wāhanga. Tuatahi mai i te wā o te manukanuka. Ko te tinana i tenei wā faaite i te tauhohenga tika ki te pānga. Ko te atamira tuarua - Ātete. I tenei wā taunga te tinana te ki whakanui tikanga. I te wā whakamutunga o te rohirohi puta. Hei haere nga wāhanga o mua o whakamahi te rauropi ona Rahui. Nä, ko te wā whakamutunga e tino mauriora ratou. Ka rite ki te hua, i roto i te tinana timata rearrangements hanganga. Heoi, i roto i te maha ngā take e kore he reira nui ki te ora. Fakatatau ki ai, E te mauriora toa pūngao tūnguru me mutu te tinana ki te urutau.

ahotea oxidative

и прооксиданты при тех или иных условиях приходят в неустойчивое состояние. pūnaha antioxidant me pro-hāora i raro i etahi tikanga mai ki te āhua iu. Ko te hanganga o te āhuatanga muri ngā nga āhuatanga katoa e whai wāhi mātātoa i roto i te haapuairaa i te hanganga o Radicals free atu momo urupare pērā i hāora ranei. могут быть представлены разными агентами. kia māngai e māngai rerekē tikanga Paraimere o te pānga ino o te ahotea oxidative. Ka taea e ēnei hei āhuatanga pūkoro: hē i roto i te respiration punaraungao, whākōkī motuhake. могут быть и внешними. Ko te tikanga o te oxidative ahotea taea e waho. Enei, i roto i ngā, ngā paowa, rongoā, rangi parahanga me te pera i runga i.

Radicals free

E tonu i hanga ratou i roto i te tinana tangata. I roto i ētahi wā, kua meinga ai e tukanga matū tupurangi. Hei tauira, i reira he Radicals hydroxyl (OH). e pā ana ratou ahua kei ki te puaretanga tonu ki ionizing radiation me ngā taumata iti o te tuku superoxide tika ki irahiko leakage me ratou mekameka waka. I roto i te tahi atu te wā, te takanga o Radicals tika ki te faaitoitoraa o phagocytes me te hanga o te waikura nitric i ngā pūtau endothelial.

Ko te tikanga o te ahotea oxidative

Tukanga takanga o free tuwhena whakautu rauropi me te whakapuaki āhua taurite. I roto i tenei take, ko reira tino ngāwari ki te neke toenga whanaunga i roto i manakohia o te Radicals. . Ka rite ki te hua o te mataora pūtau fakahohaasi me te ahotea oxidative puta. Te nuinga o nga mea timatanga i roto i te tūranga ki te aro ki te tohu āhua o te tāne i. Ko e tika ana ki te aroaro o ngā pūtau i roto i ngā hanganga reparative tenei. tautuhi ratou ka tango rāpoi pakaru. I te wahi whakamutunga tūemi hou tae. . I tua atu, i te pūtau i te kaha ki te whakarei ake i te tiaki, i roto i te whakautu ki te ahotea oxidative. Hei tauira, kiore e whakanohoia i roto i ngā āhuatanga ki te hāora parakore, mate i muri i te torutoru nga ra. Kei te mea te reira i e i roto i te hau noa kei pā ana ki 21% e _2. Ki te te pānga i runga i nga kararehe āta piki haere pota o te hāora, ka kia whakakaha ratou tiaki. Ka taea e te hua te tutuki e te kiore, me te kia e taea ki te whakawhiti 100% e ₂ kukū. способен вызвать серьезные разрушения или гибель клеток. Otiia, ka taea e te ahotea oxidative kaha meinga kino ranei te mate pūtau.

āhuatanga whakahōhā

Ka rite ki runga ake whakahuatia, tonu te toenga tinana te Radicals free, me te tiaki. вызывается как минимум двумя причинами. Mai i tenei e taea e tatou e faaoti e oxidative ahotea meinga e te iti rawa e rua ngā take. Ko te tuatahi ko te ki te whakaiti i te mahi tiaki. Ko te tuarua ko te ki ake i te hanganga o Radicals ki te tohu taua e te antioxidants e taea ki te haamou i ratou.

whakautu paruru iti

Kei te mohiotia te reira e te pūnaha antioxidant ko te nuinga ti'aturi i runga i te kai tōtika tika. Fakatatau ki ai, Ka taea te faaoti i te reira e te whakaiti i roto i te tiaki o te tinana, ko te hua o te kai rawakore. I roto i te tūponotanga ka katoa, meinga maha mate tangata e hē o ngā matūkai antioxidant. Hei tauira, kitea te neurodegeneration te tika ki te horomanga iti i roto i tūroro kore e taea metabolize tika purena tonu huaora E nei te tinana. He he ano hoki taunakitanga ki te whakaaro e HIV-huaketo iwi, whakahokia kitea i roto i lymphocytes glutathione i roto i nohanga tino iti.

kai paipa

Ko tetahi o nga āhuatanga matua meinga oxidative te ahotea i roto i te pūkahukahu, me te maha atu te kopa o te tinana. Paowa, me te teriuma Radicals taonga. E ahei o te whawhai i te rāpoi ngota, me te ki raro i te kukū o te huaora E me C. Smoke irritating ki macrophages pūkahukahu, reira whakaputa superoxide etahi o ratou. I roto i te pūkahukahu o kaipaipa i reira he nui ake neutrophils atu-hikareti kore. tūkino Tupeka, maha kai iwi painga ka pau waipiro. Fakatatau ki ai, ratou ngoikore korero. провоцирует тяжелые нарушения клеточного метаболизма. Ma'i ahotea oxidative whakaoho te ofatiraa nui o pākia pūtau.

Huringa i roto i te tinana

No te mau opuaraa tātaritanga, mā te whakamahi i te momo o tohu o te ahotea oxidative. Enei ranei ētahi atu whakarerekētanga i roto i te tinana tohu te tauwhāiti disorders pae me ngā āhuatanga, ki whakapataritari ia. : I roto i te ako o te hanganga o Radicals free i roto i te whanaketanga o te sclerosis maha te whakamahi i taua tohu o te ahotea oxidative:

1. Malondialdehyde. E ohipa te reira hua tuarua o free hāora tuwhena (CPO) lipids me he kino ki runga i te hanganga me te mahi o te membrane. i roto i te tahuri arata'i tenei ki te hua i roto i to ratou uruhanga ki katote konupūmā. Te whakanui ake i te kukū o te malondialdehyde i te akoranga o matua me te tuarua-ahu whakamua taahiraa matamua sclerosis maha fakapapau'i ahotea oksislitelnogo - faaitoitoraa o free hāora tuwhena.
2. turanga Schiff Ko te hua mutunga o sro-pūmua me lipids. Te whakanui ake i te kukū o Schiff turanga haapapu te hehema o whakahohenga ma'i o free hāora tuwhena. Ki te nui ake kukū o malondialdehyde i tua ki te hua, me te o matua i sclerosis ahu whakamua Tuarua kia tohu i te timatanga o te tukanga haamou. takoto te reira i roto i te wāwāhi me te whakangaromanga o nga kiriuhi muri. taumata teitei o Schiff turanga tohu hoki te wāhanga tuatahi o te ahotea oxidative.
3. He Huaora E. reira taunekeneke he antioxidant koiora ki Radicals free me peroxides lipid. hua whakataimaha i hanga i roto i te tauhohenga. oxidized Huaora E te. Kei te whakaaro te reira i te neutralizer whai hua o te hāora hingareti. E tukupu te mahi o te huaora E i roto i te toto tohu he tāne i roto i te pūnaha hono AO3 kore-enzymatic - i roto i te poraka tuarua o te ahotea oxidative.

pānga

? He aha te mea te tūranga o te ahotea oxidative? E tano ia tapao e te puaretanga e kore anake lipids membrane me pūmua, engari te warowaihā. I tua atu, timata te huringa i roto i te pūnaha hormonal me endocrine. heke whākōkī Active hanganga lymphocytes thymus, faarahi te taumata o neurotransmitters, timata hormones ki kia tukua. A, no te haamata te ahotea waikawa karihi oxidizing, pūmua, waiwaro, faarahi te ihirangi whānui o lipids i te toto. Whakarei tuku o te taiaki adrenocorticotropic tika ki te kaha ATP mimiti me puni tupu. Last ko te kupu whakahohetia te kinase pūmua. Ia, i roto i te tahuri, whai wāhi ki te whai wāhitanga o ATP phosphorylation cholinesterase hākawa Liliu cholesterol i roto i cholesterol noa. Ngä o te kōtuitanga pūmua, RNA, DNA, i te wā kotahi glycogen roopu o ngako taupuni, fatty kiko pirau (teitei) waikawa me te kūhuka i ai hoki oxidative ahotea. считается одним из наиболее серьезных последствий процесса. Aging Ko tetahi o te mau hopearaa tino nui o te tukanga. Ano, i reira te mea he tipu mahi o hormones thyroid. E whakarato ana i te tere ture BMR - tupu me te pārōnaki o te kopa, te pūmua, lipid, warowaihā pākia. wāhi nui mō te glucagon me te taiāki. E ai ki etahi tohunga, mahi te kūhuka rite he tohu mo te faaitoitoraa o adenylate cyclase, a tsMAF - mo te hanga o te taiāki. arata'i tenei katoa ki te whakakahanga o te pirau o glycogen i roto i te uaua, me te ate, tērā iho te biosynthesis o te warowaihā me te pūmua, tērā kūhuka piti hāora. Whakawhanake te pauna tōraro hauota, faarahi te kukū o te cholesterol me ētahi atu lipids i roto i te toto. whakatairanga Glikagon te hanganga o te kūhuka, inhibits tona whāwehe ki waikawa lactic. I roto i tenei take, karapotia reira ahu ki nui haere gluconeogenesis. Tenei tukanga Ko te ariā o ngā hua warowaihā-kore, me te kūhuka. Ka rite ki te waikawa tuatahi mahi pyruvic me waikawa lactic, nonireka, me te tetahi pūhui e taea kia puta ki te catabolism o pyruvate i ranei tetahi o nga mea timatanga takawaenga trikarbonovokislotnogo huringa. E hoki nga substrates matua waikawa amino, me te lactate. He tūranga matua i roto i te huringa o te warowaihā no ki te kūhuka-6-Phosphate. Tenei pūhui tino pōturi raru glycogen fosfoliriticheskogo. Kūhuka 6-Phosphate whakahohe te waka kūhuka paru i roto i uridindifosfoglyukozy glycogen synthesized. mahi hoki i te pūhui rite te tïpako mō panoni muri glycolytic. Fakataha ki tenei reira ko te tipu haere ariā o whākōkī gluconeogenic. I roto i ngā, he reira angamaheni mo phosphoenolpyruvate carboxykinase. whakatau te reira i te tere o te tukanga i roto i te whatukuhu, me te ate. Ko te ōwehenga o te gluconeogenesis me glycolysis te hünuku ki te tika. Ko te glucocorticoids hei whāpoapoa o whākōkī kōtuitanga.

tinana ketone

mahi ratou rite te ahua o kaituku wahie mo te whatukuhu, uaua. nui te ahotea, no te oxidative o tinana ketone nui haere te. mahi ratou rite te regulator ki te ārai roopu nui o waikawa ngakongako i te taupuni. Tenei kei te mea i roto i te kopa maha tīmata kaimahi pūngao e tika ana ki te meka i kore e taea ki te tomo ki roto ki te pūtau te kūhuka e tika ana ki te taiāki hē. I nohanga tiketike o waikawa ngako i roto i te wē e faarahi ratou absorption me hāora o te ate, faarahi te kaha o te triglyceride kōtuitanga. arata'i tenei katoa ki te hua i roto i te maha o tinana ketone.

ato'a

mohio Pūtaiao me tenei āhuatanga rite "tipu ahotea oxidative." Kei te mea te reira e ki te pātai o te pū ahurea urutau ki te whānuitanga o ngā āhuatanga tonu i tautohetia i tenei ra. Ētahi kaituhi whakapono e raro i ngā āhuatanga kino nga tauhohe matatini o te natura ao. e kore te mea ti'aturi i runga i te āhua o te take Ko tōna mahi. Ētahi atu tohunga tautohe e takoto te pūmautanga o hua e whakautu motuhake. E ko, te tauhohenga he tika tauwehe. Na, ko te nuinga o pūtaiao whakaae e ki te whakautu kore-motuhake, me te motuhake puta. I roto i tenei take, e kore e taea tonu te mua ki te kitea ki te papamuri o maha tauhohe ao.