Taero Nonsteroidal anti-inflammatory - he raau rapaau ranei te kaikohuru puhoi?

Nuinga o ngā wā e whakamahia ana i roto i te mahi protivovspalitelnye taero haumanu nonsteroidal, NSAIDs ranei. E whakaritea ratou i roto i ngā tukanga inflammatory o te etiology kanorau mō te rapu i te pūtake o te mumura, mamae te tauturu, kirika, whakaiti i te mōrea o te Thrombosis (te mua ahipirini katoa). E ai ki ngā tatauranga i te WHO, enei taero pau e pā ana ki 30 miriona iwi i nga ra katoa, me tetahi anake toru o ratou - whakahaunga o te tākuta. Ahakoa ngā tau atu faahiahia, ngā i roto i mate rūmātiki. I kitea te reira e taero anti-inflammatory mō te tahi tukua e pā ana ki 80% o rheumatologists.

Ko ahakoa he mahaki rongonui enei taero? e kore he whai huatanga haumanu o roto pātai, engari kua etahi fakangatangata, no te mea e taea ara pota iti mō te whakahaere wā-poto hoatu pānga taha i roto i te 25% o tūroro, me i te 5% o te wā he ora-te whakawehi. Rawa, āwangawanga reira te paari, a i roto i te meka hanga ratou ake 60% o ngā kaiwhakamahi NSAID katoa.

A, no te kitea hoki i roto i te o 70 te parau tumu o te mahi o enei taero (inhibition o mahi cyclooxygenase, te paru matua whai wāhi i roto i te pākia o prostaglandins), ka reira mārama e herea te pānga taha e ki kia te whanaketanga o abnormalities i roto i te rere toto tākihi, me wahi gastrointestinal. I muri i te katoa, prostaglandins (PGs) whai wāhi nui i konei. I roto i te 90, meka hou e pā ana ki te tūranga o GHGs i te akoranga o te tukanga tino nui i roto i te tinana tangata. Fakatatau ki ai, vozdestvuyut taero anti-inflammatory te whānuitanga katoa o ngā tauhohe ora, i roto i ngā mo toto upoo- me te reo iaia, wheua pākia, embryogenesis, tupu o ngā pūtau io, kiko hanga, me te tini ke atu.

I te wa ano i whakakitea ai e reira e rua isoforms o cyclooxygenase: Cox-1 me Cox-2. Ano, ko te haepapa tuatahi mo te mahi noa o te whekau i te taumata pūtau, me inhibition o te tuarua whakaatu tika i te pānga haumanu. Ko te kupu, te whakaputa taero anti-inflammatory e taea mahi tīpakongia i runga i Cox-2, ko reira taea ki te whakaiti i te takanga o ngā pānga taha me te maimoatanga haumaru tino.

Ko tētahi o ēnei āpiha whiriwhiri ibuprofen te. E ai ki tata katoa rangahau, kua whakaritea iti te mōrea o te takanga o pathologies gastrointestinal i tona fariiraa ki, hei tauira, piroxicam.

Āhua tata kitea tetahi pānga taha e ai kore-steroidal taero anti-inflammatory. Ratou tino whakaiti oro iaia, i te mea rawa kino hoki te iwi e mate ana i te mate ngakau. I roto i te tūroro te whiwhi NSAIDs puta, rite ki te tikanga, nui haere te pēhanga toto, me te te nuinga o te ruhiruhia e whakahau enei taero mo te mamae rūmātiki, te tikanga kē he hītori o te takawhita.

I tua atu, whakaiti NSAIDs te tōtika o te mahi diuretic o maha rongoā antihypertensive. I roto i ngā, i te pota haumanu toharite o indomethacin, naproxen me piroxicam taka ranei rongoā kei roto furosemide me hydrochlorothiazide, prazosin pērā i taero captopril ranei. Heoi, ka rite ki ka mohiotia e te mahi whiriwhiri o raau taero i runga i nga isoforms rerekē o Cox, rite whakahuatia i runga ake, e kore e tino pā te pūnaha Cardiovascular. Ko te kupu, i reira tonu he mara nui o mahi mo te hanganga o te raau taero tino whiriwhiri ki iti pānga i runga i te pēhanga toto, me te tika tino mo te ruhiruhia. Na kua tīmata enei taero ki puta. Hei tauira, riro Cox-2 selectivity nui meloxicam, celecoxib.

Kia aroha mai, pakeke Luda kore anake maha whakahau ratou nonsteroidal taero anti-inflammatory mō maremare, mo te tauira, i waho he mahara ki nga mau hopearaa taea katoa. He tino pakeke NSAIDs ki te whakakapi i te tahi mea, engari ki te aromātai i te whai huatanga o te tarukino mo mōrea katoa taea taea anake rata tohu.