Ko te tarukino "Clayra": te arotake i nga kaitohutohu, nga putea, nga putea, nga tohutohu, nga paanga taha. Ko nga korero mo nga kaiakiko mo nga papa o Claira me te mutunga o te mate, me te menopause

Aita i maoro a'e, tino maha tākuta hou i roto i etahi mate whakahau te tarukino "Klayra". Reviews o kaiwhakaako, AtAKi, raruraru o tenei taputapu - ka tenei katoa e kōrero i raro.

e ratou mahi pehea?

Tenei tarukino Ko te ngā ārai hapū ā-waha, e hāngai ana nei i runga i te pāhekoheko o te maha ngā āhuatanga. Ko te nui rawa o nga ratou ko te pehanga o te kano, me te te whakatikatika o nga āhuatanga o te hūpē te waha - i runga i tenei ka hāngai mahi "Klayra" tarukino. Reviews o kaiwhakaako (AtAKi, whakaaro tonu raruraru tohunga) maha mea e ko te reira tu te taputapu i roto i roto i tona pānga rite.

I tua atu ki te ārai hapūtanga e hiahiatia rerekē tenei tarukino he raupapa katoa o atu āhuatanga painga e, ara tango ki pūkete tetahi huru maitatai kino tukua ki a koe te whiriwhiri i te kōwhiringa pai o ārai. contraindications katoa ki te tarukino whakaahua ana "Klayra" ako. ngā ano Reviews rata mōhiohio e pā ana ki te hunga ki te tango i tenei rongoā houhou.

He aha hanga he whakarite?

Whakaiti i te kaha o te mamae me te menstrualnopodobnoe toto, e te mutunga arata'i ki te whakaiti nui i roto i te mōrea o te rino hē anemia. Ko te pānga matua, e whakarato ana i te "Klayra". Reviews o tākuta (AtAKi / raruraru o te cm tarukino. Raro) mea e whakaratohia tenei katoa e ki te tonu, i roto i te hononga ki ai te medicament, me te tūtohu i te whakamahi o na maha. I tua atu, tino maha kitea me e te fariiraa o te taputapu whakarato he whakaiti nui i roto i te taea o te whakawhanake i te mate pukupuku endometrial. Ano, te whakaiti i te raau taero i te mōrea o te mate pukupuku ovarian.

He aha te mea mau taote?

No nia i te tarukino "Klayra" whakautu i rata maha ngā te meka e te mea he pānga tino painga i runga i te endometrium, i roto i te hononga ki nei whakamahia ai i roto i te maimoatanga o te wā-roa kaha rawa toto paheketanga ranei kahore māuiuitanga organic. Ko wā ēnei tohu toto uterine aueue. Tenei meka tohatoha wātea e pā ana ki te tarukino "Klayra" whakautu i rata. I roto i te endometriosis hoki e taea te whakaritea tona whakamahi.

rangahau

Te haumaru me te whai huatanga o te whakamahi i papa estradiol valerate / dienogest i te maimoatanga o tohu o toto uterine aueue kua tāutuhia i roto i te akoranga o rangahau haumanu rua.

whakamahia te mahere hoahoa tākai me te tātari i taua i roto i akoranga e rua. I te pae hopea, i tīpakohia 269 tūroro mō "Klayra" tarukino. (E whakaahuatia AtAKi / raruraru i roto i te taipitopito) Reviews o kaiwhakaako, tango wahi i roto i te ako, ka mea e i roto i te tua ki tenei te mea kua whai wāhi i roto i te ako o 152 tūroro, i whakamatauria te pānga o te placebo. I roto i enei akoranga, ka takoto te tikanga a nui atu te whai hua te tarukino whakaritea ki placebo i te maimoatanga o enei tohu, a ko reira utu te tuhituhi i te meka e te whakautu, koirä ki tarukino "Klayra" he neke atu i te 40% i roto i ia o nga akoranga.

I tua atu, mārama faaite ia o nga akoranga he whakaiti tauanga me hauora nui i roto i te mate toto paheke, me anō i haere tahi ai i te hua nui i roto i te rino tawhā ka pākia e tēnei wā maha tohu te tikanga o "Klayra 'arotake o kaiwhakaako (nga pai me ngā raruraru o tenei hua e whakaaro tatou) .

Ka rite ki estrogen i roto i tenei faaineineraa tavini variat estradiol, i te mea he kawainga tūturu o te tangata 17β-estradiol. wāhanga Estrogenic whakamahia konei te tikanga rerekē tino i te estrogens e e whakamahia nuitia i roto i te whakawhānau kōrero ngā, i he paerewa estrogen waihanga, pērā i mestranol ethinyl ranei, ia o nei kei roto i te rōpū methyl i roto i te tūranga 17α. Tenei rōpū ai te pūmautanga pūkoro nui nui, engari i te wa taua he pānga atu korerotia i runga i te ate, i te mea ano hoki rawa nui.

I roto i te whakaahuatanga o te faaineineraa "Klayra" whakautu i rata maha kōrero ki te meka e tango i te reira tuku nui iti korerotia pānga i runga i te ate whakaritea ki te tahi atu PDAs toru-wāhanga, e ngā levonorgestrel me ethinyl estradiol. I roto i te rangahau i takoto te tikanga e te pānga o te kukū o te globulin hangaia ki te here hormones, he iti korerotia. I roto i ngā ki dienogest valerate estradiol whakaatu te hua nui i roto i HDL, i heke te tapeke kukū o te LDL cholesterol te.

Dienogest - he progestogen, mahi i roto i te take o te whakahaere ā-waha. Kei te āhuatanga i te reira e atu pānga anti-androgenic kanohi, i he iti ona anti-estrogenic, āhuatanga androgenic me estrogenic. Nā ki tutuki te hanganga matū ahurei e te tūāwhiorangi katoa o mahi pharmacological, e ngā o te painga tino nui o 19-ranei-progestogen, me te ngā pärönaki o te taiaki, e te tino maha parau e pā ana ki te tikanga e wātea ana "arotake Klayra '(AtAKi / ka e kōrero raruraru i muri).

Tetahi raraunga mua-haumanu i whiwhi i te akoranga o rangahau noa te tāoke i muri dosing maha, me te genotoxicity me te pūmanawa carcinogenic o tenei taputapu, kahore whakaaturia, e reira e etahi mōrea motuhake nui ki te tangata. maha mea Heoi, i roto i te whakaahua i te tarukino "Klayra" arotake gynecologists e kore e tatou e wareware e pā ana ki te taea o te whakaongaonga i te maha o te kopa taiaki-ti'aturi me puku hormones sex. I roto i te take o te whakamahi tika o te pera-ka karanga Index Pearl (he mehua e whakatau te auautanga o te hapūtanga i roto i te wahine i runga i te tau kotahi rau o tono o te tarukino) he uara iti iho i te 1, engari i roto i te take o papa ngaro faaino i o reira ranei e taea te tupu.

pharmacokinetics Panuku "Klayra" ka kia whakaaro te tarukino. Reviews gynecologists tata rawa te whakaū i te kōrero i tohua e te kaiwhakanao, i roto i te hononga ki ai te taputapu, ka whakaritea ki te tūroro maha.

dienogest

• Absorption. I muri whakahaere-waha te huānga tere me tata rawa whenumi. _max C i roto i te serum toto tae te tohu 90.5 ng / ml i muri e pā ana ki te haora i muri i tangohia i te papa kei (kei reira 3 mg o dienogest me 2 mg estradiol variat). Bioavailability i roto i tenei take tae te ūnga o 91%. Me kï reira e te āhuatanga nga pharmacokinetics o dienogest i roto i te awhe inenga i te 1 mg ki 8 fakafalala tika i runga i te horopeta. Ki te whakamahia te faaineineraa te tukutahi i te kai, e kore e meinga te reira i tetahi pānga hauora nui i runga i te tohu auau ranei o absorption o tenei huānga.

• Distribution. He wāhanga nui o te dienogest komuhumuhu (10%) kei roto i te puka herekore, i te toenga he here kore-motuhake ki albumin. Kei te Dienogest ano kore hāngai e pā ana ki tetahi globulin kortikosteroidsvyazyvayuschim, ranei SHBG ki. Ko reira hoki tenei take e te tino whakakorea testosterone te mōrea o displacement o te hononga ki te SHBG cortisol ranei i te kōrero o te huānga ki te DRG. He mana ngā i ngā tukanga whaiaroaro neke steroids endogenous, aua, ko ngā taea. A, no te te kukū taurite ko 46 V _d L rite ki te hua o te whakahaere rō-uaua o te dienogest 85 mg tapaina ki tritium.

• Pākia. Kei te tata rawa metabolized Dienogest huānga i roto i te hanganga ture ki tonu ki nga ara mohiotia tēnei wā o te pākia o hormones pūtaiaki, me te te hanganga o metabolites e te hunga i roto i te nuinga nui o te wā hormonally tautauā. E excreted ēnei metabolites rawa hohoro ai te totohe tino i roto i te wē toto tu dienogest tonu. whakawātea Tapeke i muri i whakahaere rō-uaua o te dienogest tritiated he 5.1 l / h.

• Whakakorenga. Ka rite ki te hua o te fariiraa i tenei huānga horopeta waha o 0.1 mg / kg tino i roto i dienogest rite metabolites e kua excreted e nga whatukuhu, me paru i roto i te ōwehenga āwhiwhiwhi o 3: 1. I muri i whakahaere waha o āhua 42% o te horopeta te tino nekehia i roto i te ra tuatahi, i te 63% - i runga i 6 ra i te excretion tākihi. I tua atu, i muri i te 6 ra i roto i te whēkau, me te tākihi ahu e pā ana ki 86% o te horopeta.

• Ko te kukū taurite. I roto i tenei take, e kore e nga pharmacokinetics o dienogest rānei i runga i te kukū o SHBG. tutuki Tūtohu C _ss te muri e pā ana ki nga ra e toru i muri i te whakamahi i te taua horopeta, i te mea 3 mg dienogest i roto i ngā ki 2 mg Estradiol valerate.

valerate estradiol

• Absorption. Ka rite ki te hua o te tango i te estradiol tarukino tauira pai hohoro a tino whenumi. Wāhinga i te waikawa valeric me estradiol iho tika kawea atu i roto i te momi o te huānga i roto i te mucosa wahi kūnatu ranei i roto i te irava matamua i roto i te ate, reira puta estradiol me ona metabolites. Ki te tangohia te kaihoko te tahitia ana ki te kai, te mea kahore pānga hauora nui i runga i te whānuitanga auau ranei o absorption o tenei huānga.

• Pākia. waikawa Valeric rerekē pākia tino tere. I muri i whakahaere waha o āhua 3% o te horopeta, riro te reira tino bioavailable rite estradiol parakore pangia kaha pānga tuatahi haere i roto i te ate, kia e tīmata te wahi nui o te horopeta faaterehia metabolized kē i roto i te mucosa o te wahi gastrointestinal. I roto i ngā ki pākia presystemic i roto i te ate tika e pā ana ki 95% o te horopeta-waha metabolized te mutunga i mua i haere ki roto ki te tohanga nahanaha. Ko te metabolites matua konei mahi estrone pūkawa, estrone me estrone glucuronide.

• Distribution. I roto i te serum te pā tika 38% o te estradiol ki SHBG, i 60% - ki albumin, me 2-3 anake% te tonu huri i roto i te āhua herekore. Ko ia tapao i te meka e kia whakanui i insignificantly estradiol te katoa kukū o SHBG i serum toto, reira me ko tenei pānga tika ti'aturi i runga i te horopeta whakaaetanga. I te ra 21, ko te tapeke kukū o SHBG ko te fariiraa o tenei faaineineraa āhua 146% o te taketake, i te ra 28, i te mea te wāhanga mutunga o te tono o papa hohekore kua heke ki te 141%.

• Whakakorenga. No te mea ko te poka wai makona nui o komuhumuhu glucuronides me ngāwhā, rite pai rite no te mea o te recirculation hepato-enteric T _1/2 estradiol i muri i te whakamahi ā-waha i roto i te wāhanga kāpeka he āhuatanga matatini, tika ti'aturi i runga i enei tukanga katoa.

• Ko te kukū taurite. tika tei Pharmacokinetics estradiol i runga i te kukū o SHBG. I roto i nga wahine, i te kukū o te estradiol i roto i te wē toto ko te matatini o estradiol endogenous, me taua estradiol e tomo te tukanga o te fariiraa i tenei tarukino. I roto i te papa wā fariiraa, e roto i 3 mg o dienogest me 2 mg estradiol valerate, te kukū toharite o estradiol i roto i te serum toto i kāwanatanga ravnomestnom ko 51,6 wh / mL.

A, no te whakamahia tenei tarukino te?

Tuatahi whakaritea "Klayra" i roto i menopause. Reviews o taote mea e ko te pai rawa pai mo te maimoatanga o wahine e mate ana i te paheketanga taimaha roa ranei toto i roto i te ngaro o tetahi māuiuitanga waro tenei.

Ano hoki, i tangohia tenei tarukino te ki te whakamahi i ārai-waha.

contraindications

I te faaineineraa "Klayra" whakautu i rata (pānga taha - ki te kupu) E kore te mea pai i nga wa katoa. Hei tauira, tohatoha etahi contraindications. Kia mōhio te torutoru tikanga mo e kore kia whakamahia tenei taputapu, a ko te kupu i te fariiraa ko ki te kia tino whakakorea ki te tīmata tetahi o ratou ki te whakawhanake i roto i therapy:

• tūtohutanga nui ki tetahi o nga matū kaha ki etahi-wae iti ranei;
• Embolism Thrombosis ranei inaianei ranei i roto i te aamu;
• kāwanatanga, e he Thrombosis-mua e rua i roto i te hītori me te i roto i te hakari;
• faaite predisposition tuku riro ranei ki te putanga o te matua Thrombosis venous, tae atu hoki te hē o te antithrombin III, pūmua C me te S hē, paturopi ki phospholipids me gipergomotsistsinemiya ranei;
• te aroaro o te matua teitei Thrombosis venous ranei;
• te aroaro o te migraine ki tetahi tohumate neurological wāhi rite i te kau, me te hītori;
• mate huka, āhuatanga e ngā pōauautanga iaia;
• pancreatitis, hypertriglyceridemia nui he wa kaha hītori ranei;
• mate ate kino ranei kore ate wātea;
• taiaki-ti'aturi pukupuku whakaaturia māharahara o ratou takanga ranei;
• pukupuku ate;
• hapū ranei te whakapae o reira;
• toto tara o te take unknown;
• te aroaro o te reihuka, malabsorption klyukozo-galactose lactase hē ranei.

I tua atu, ko reira utu te tuhituhi tetahi atu take i roto i e kore e taea te whakamahi pire mana whanau "Klayra". mea arotake o tākuta e kore e ratou e tangohia i roto i te whāngai ū.

faaararaa motuhake

Ki te kitea etahi mate, tikanga āhuatanga mōrearea ranei whakahuatia i raro nei i roto i te tangata i te wa nei, ka hiahia ki te kia tino āta whakaaro i te mōrearea, me painga o tango tenei tarukino i roto i te take ia takitahi. I roto i ngā, pā tenei ki te āhuatanga e whai ake nei:

• āhuatanga mōrearea hoki te whanaketanga o te thromboembolism me Thrombosis muri;
• Ētahi atu mate i roto i e taea te kite rerekē disorders circulatory piringa;
• hypertriglyceridemia;
• aroaro o te edema angioneurotic tuku;
• tini o nga mate, i te tuatahi puta ranei te mauähara o te wā hapū ranei i roto i te whakamahi o mua o hormones sex.

e kore e tangohia "Klayra" papa i roto i enei take katoa. Reviews o tākuta i roto i tenei āhuatanga ki te āwhina kia mau tonu te hauora.

Pregnancy me uma-kai

contraindicated te whakamahi o tenei tarukino te i roto i te hapūtanga. I roto i tenei take, i reira e taua āhuatanga ina puta haputanga i roto i tūroro te whiwhi e pā hoki ki te tarukino "Klayra" ako ā-ringa. Reviews o taote mea e i roto i tenei take e hiahia ana koe ki te Kati aru tonu i te fariiraa. Heoi, i roto i te akoranga o te mau ana i rangahau nui-tauine nui haere mōrea o tetahi kohakore whanau i roto i ngā tamariki e kore i takoto, whanau ki te wahine nei ka mau te CPC rite i mua i haputanga me i roto i to ratou fariiraa tüao i te timatanga o te hapūtanga.

CPC ētahi wā pā hohipera, rite ratou kia pēhia ngā te nui o te waiu hua ranei tae noa ki te huri i tona hanganga, e maha nei whakahuatia e pā ana ki te faaineineraa "Klayra" whakautu i rata. mo tenei take, e kore e tūtohutia tona whakamahi rawa i muri i te 40 tau.