"Carvedilol": arotake. Tohutohu mō te whakamahi o te raau taero, analogues, utu

I roto i te rārangi o rapua-i muri i taka cardiac "Carvedilol" mai te wa roa. tohunga te āheinga whakaahua ia rite te maimoatanga-kounga tiketike mō te kore te ngakau, me te mana o runga i te kōpuku AV i roto i fibrillation Atrial. Reira hoki e taea te whakamahia whānuitia mo te maimoatanga o te takawhita, e hanga ana e ia he tarukino rawa faufaa. Hoki tenei take, he maha kamupene rongoā synthesized me hokona whānui "carvedilol". He ona ake āhuatanga o tuku, me te whakatū o ngä nohanga toto whakaora ia o ratou. Ahakoa i roto i te whānui mahi ratou ratou mahi.

Mai i katoa o te tarukino "Carvedilol" ritenga nga āhuatanga nui taua, i reira he kahore faufaa tūturu ko e o ratou kia tīpakohia mō te maimoatanga. Ahakoa whakaatu rangahau bioequivalence, kaihoroi me te pānga ngawari whai atu te utu tarukino kano me te taketake. Na reira te whāinga o tēnei arotake ko te pai analogues kounga kōwhiringa ki uara whakaora tiketike.

medicament āhuatanga Pūnaha

Ka rite ki āpiha haumanu, kua kï "Carvedilol" analogues me taero whānui whai hua. taonga tarukino takekore pā ki te piha haapiiraa o te whakauru i-blockers. E aukati ratou e rua ngā momo o te Adrenaline me noradrenaline receptors: alpha me beta-receptors o te momo tuatahi. Ko te kei tuatahi i roto i te ngakau, me te tuarua - i roto i te uaua o oko toto. Hëoi ratou, whakaongaonga te raau taero te whanaketanga o te maha ngā pānga haumanu.

I roto i te piha haapiiraa pūārai o raau taero i roto i "Carvedilol" E kore analogues o te tarukino. He he taonga ōrite anake i runga i nga tikanga o te mahi. I roto i ngā, i te tarukino he tata "Nebivolol", he hoki he pānga ahurei. He hoki ritenga piha atu ohie. aroaro ratou cardioselective, e he whiriwhiri ki te faatura ki te receptors beta-adrenergic o te momo tuatahi, "metoprolol" me "bisoprolol".

Whakaritea ki "metoprolol" "Carvedilol" atu whiriwhiri mo te beta-receptors, e whakaatu ana tata rite "bisoprolol" hunaonga mō receptors beta-adrenergic cardiac. I roto i tenei faaineineraa "Carvedilol" Ko reira ano hoki he antioxidant kaha. He tino nui mo te TEETH o te taiepa iaia, kua pāngia e te tukanga o te te atherosclerosis tenei pānga. E ai ki te faufaa o tenei taonga pŭpŭ tauturu o te raau taero e homai nga āhuatanga ahurei o "Nebivolol." ai te reira i whakahohenga azotzavisimyh āhuatanga endothelial, a reira ko ahei o ārai pāpaka atherosclerotic o pera.

Pharmacodynamics "carvedilol"

rongoā Modern "Carvedilol" e tika ana ki te pānga o te beta pā o momo e nga pānga e whai ake nei e ahau:

• te whakaiti contractility myocardial mā te whakaiti i te hiahia mō te kai tōtika uaua cardiac me te hāora (antianginal);
• Ko te ahei o hëoi automaticity me kawe ia (mahi antiarrhythmic);
• inhibits te reira i te pūnaha renin-angiotensin o te tinana (pānga antihypertensive);
• te whakaiti i te hautanga o te putanga cardiac ki te whakaiti pēhanga toto systolic;
• nehenehe o whakawhänui piringa oko moenga.

Kei te pai te pānga muri faaite "Carvedilol". Reviews o te whakamahi ma'i o te tarukino tohu he pā o nga pānga o adrenergic Arepa-kotahi Momoroto. E tū ana i roto i te piringa, arā oko uaua. arata'i ratou pā ki te whakarerekē pū o pera iti. whakaoho tenei he maturuturunga iho i roto i te katoa resistance rere piringa, hua i roto i te pēhanga toto raro me te whakapai ake i te mana uaua.

kua he "Carvedilol" analogues me taero whānui i roto i te uaua kōhiwi kore anake, engari i roto i te ngakau te pānga rite. rau tenei te taea o tona whakamahi i roto i te tūroro ki te kore te ngakau ma'i, pōreareatanga e ischemia ma'i (mate te AVC). A mai "Carvedilol" Ko 1 whiriwhiri beta-pūārai ki te tetahi ara pakuwha mō Arepa-1-receptors me ngā āhuatanga anti-āpitihāora, tona whakamahi rite whānui.

Ko te whakamahi o "carvedilol"

Mai te āhuatanga pharmacodynamic o te tarukino pai tohu "Carvedilol", arotake o tona tono kia rānei whakapumautia enei whakataunga ki te turaki whakawa hape ranei. Ko te pānga pai o te tarukino kua kua oti ia te whakamatautau, mo te kore he refutation raro ki tetahi o nga meka. Hoki tenei take, "Carvedilol" whai hua rite te tarukino e hiahiatia ana i roto i te āhuatanga haumanu e whai ake nei:

• mate cardiac rere pūroto;
• kore ngakau ma'i;
• tachyarrhythmia;
• angina, infarction myocardial whakapeka, angina iu;
• takawhita.

iteraa papû

I roto i te faaineineraa puta "Carvedilol" tohu i ona āhuatanga pharmacodynamic. Nā ki te pēhanga toto raro, whakaiti mua- me te afterload i roto i te myocardium, a hoki no o te pānga antiarrhythmic o taea te whakamahi i roto i te take o te mate e whai ake i te tarukino:

• takawhita II a III tohu i roto i te hanganga o te maimoatanga ngā taurite;
• takawhita tohu ahau i monotherapy mōrearea Cardiovascular tiketike;
• ki tachyarrhythmia: Atrial Fibrillation puka pūmau, ki te arrhythmia supraventricular auau;
• i roto i te mate ngakau coronary ki faaiteraa whakapeka (angina iu infarction myocardial ranei);
• ki IBS Ko ngā kaupapa whakapeka (kaha angina, angina ahu whakamua);
• kore ngakau ma'i, i te atamira o hiia Vasilenko-Strazhesko FC NYHA III ranei e te hanganga whārite o te maimoatanga ngā;
• i roto i te symptomatic takawhita me pakohu tachycardia e pā ana ki hyperthyroidism pheochromocytoma ranei.

hoki kitea e nga tohu o te raraunga ngā hua "Carvedilol" ritenga. E whakamahia ratou i roto i te mate cardiac tino noa, arā, ki te mate te AVC me kore ngakau. Ano, i reira te mea ano hoki te tarukino te hōkai whānui o tono. Ko reira takawhita matua faufaa, ahakoa symptomatic, whakapataritari hyperthyroidism pheochromocytoma ranei, a tōtika te mana e te beta-blockers.

contraindications

Ahakoa te kōtaha whakaora whānui atu te beta whiriwhiri 1-blockers i roto i te contraindications tarukino te tīariari, whāiti tona tono. "Carvedilol" e kore e taea te pau i roto i te mahi haumanu i raro i te tikanga e whai ake nei:

• huangō, COPD, no te mea o te nui haere tūpono o bronchospasm;
• Kei te riria te reira ki te tango "Carvedilol" i te auau o iti iho i te 50 ngā patu ngakau ia meneti no o te mōrea o te bradycardia mate;
• riria ki te tautapa me te whakamahi i "Carvedilol" i arrhythmias (CA-poraka, poraka atrioventricular 2 me te tohu 3) ki te kore pacemaker tūturu;
• whakamahi Kāore o te tarukino i roto i te mate ate nui;
• te tono i te raau rāhuitia i CHF IV piha mahi rite ki NYHA (HIII e Vasilenko-Strazhesko) e tika ana ki te pehanga o contractility cardiac decompensated;
• "Carvedilol" tapui i roto i te hapū, hohipera, tamariki i raro i 18 tau;
• whakamahi inadmissible i roto i te tūroro ki te mate pāwera ki tona whakauru kaha wähanga o te puka inenga ranei;
• e kore he hāngai i roto i te ru cardiogenic ki SBP 85 mm HG faaineineraa. Art.

Ahakoa te meka i qualitatively me tarukino haumaru ngā "Carvedilol" whakautu, kia ū ai ki enei tūtohutanga. E hangaia ratou ki te tiaki i te manawanui me te mātanga i ngā āhuatanga e hiahiatia. No te mea he tino contraindications raraunga, me te kore e taea te waiho hoki o te mōrea tiketike o mate maumaui rauropi.

pānga taha

Hei arotake i te pānga taha o te tarukino kore e tohu "Carvedilol" whakautu. Tūroro i roto i te aromatawai tuakiri o te pānga haumanu, me te taha. No te mea auhia e hāngai ana i runga i te rangahau tauanga. I roto i te pānga kino tino auau, whakakitea ki auau i te 1 ki te 10%, he rite whai:

• e PNS ko CNS kia whakawhanake pāhoahoa, whanoke, uaua ngoikore, disorders moe, paresthesias rite nga faaiteraa o idiosyncrasy;
• pānga Cardiovascular (bradycardia tūao tamau ranei ranei poraka atrioventricular, hypotension orthostatic, i ētahi wā totitoti, e tika ana ki disorders circulatory o te uaua i roto i te obliterating atherosclerosis);
• pūnaha romahā: tohu taea o dyspnea, popoketanga nasal, a mo te hyperreactivity arahau mate taunutia taea bronchoconstriction ranei;
• ngā pānga taha i te pūnaha kūnatu e whakakitea mamae puku, whakapairuaki, mangai maroke, korere, a uaua anake tupu kōroke ruaki ranei, kia nui haere ai ate transaminase;
• pahono pūnaha hematopoietic anake uaua thrombocytopenia leukopenia ranei;
• katoatia taea, pruritus, psoriasis rere exacerbation, a kia puta ngā tauhohe anake uaua anaphylactoid.

Hoki, mai i "Carvedilol" Ko te taonga ke ki te rauropi, kia whakawhanake tauhohenga tāoke pūnahanaha. faaite te reira i syndrome rewharewha-rite ki te whanaketanga o te mamae i roto i te wahi, kanohi maroke, ritenga mimi. I roto i tenei te faatura, "Carvedilol" nui atu pānga taha atu "metoprolol", ahakoa he pai ki te rua tuatahi te miramira haumanu.

whakamahi Rawa auroa o "carvedilol"

te tuku puka inenga Basic te tarukino - tenei capsules me papa. tangohia "Carvedilol" kei te kotahi i roto i te take o te matua takawhita , me te rua ki te mate rere pūroto ngakau, kore ngakau arrhythmia ranei. Ko te horopeta tīmatanga ko te 6.25 mg kotahi te ra, i te mea whai hua mō te rongoā takawhita. I roto i CHF therapy, tūtohutia mate ngakau coronary tachyarrhythmias ranei te ki te whakamahi i te horopeta tīmatanga o 6.25, he ra e rua. Na, i titrating te horopeta rā whakaritea te ki 25-50 mg.

He taea te tarukino me te i roto i te take o te kātakí pai takitahi tono te tonu. Kei te hiahiatia te reira ki te whakahaere i te arrhythmia ranei ki roa te ora i roto i CHF. Ko tēnei āhuatanga o te raau taero, tangohia i roto i ngā ki Diuretics me inhibitors ACE whakaroa ora. Na nui pai faatia i roto i te pire CHF "Carvedilol" atu "bisoprolol". Ahakoa hiahiatia te maimoatanga e ki te whakamanawanui i te taraiwa me ngā akomanga o ngā mahi pea mōrearea, whakaritenga kāwanatanga.

Ko te puka tuku paerewa

I roto i te faaineineraa "Carvedilol" e kore ko te utu te paearu whakatau o whiriwhiri. Ko reira nui atu pai ki te whiriwhiri i te waihanga angitu mo te manawanui ngā. Nuinga pinepine i roto i te whatunga rongoā kāinga, me te Western horahia e toru ngā momo o toketaá rongoā. Tenei 25 mg, 12.5 mg me 6.25. Kua Kikī ana te papa ki te opupu ranei i roto i ngā polymeric. Tangohia rongoā i mua i te kai, ki te hiahiatia whakaiti horopeta o mahi, i roto i te kai.

arowhānui

taero whānui ko te hunga raau taero e roto i "Carvedilol" i roto i te puka inenga ngā e tutuki te whakaritenga o te bioequivalence i rite ki te tarukino taketake. Na inaianei, i reira he nui o arowhānui i roto i te mākete rongoā kāinga, wehea ki toru ngā wāhanga rite ki o ratou utu:

• teitei utu ( "Dilatrend", "Corioli ',' Carvedilol Sandoz");
• te utu toharite ( "Karvelend" "Carvedilol Zentiva," "Teva Carvedilol");
• ki te utu iti ( "MIC-Carvedilol" "Carvedilol Belmed", "Karvetrend", "Karvenal", "Vedikardol").

"Dilatrend" Ko te utu o 450-750 moni, i runga i te inenga rānei: 6.25 mg - iti iho i te 25 mg. kitea te au rite te wā i roto i te take o te tahi atu raau taero. I "Corioli" utu o 250-500 moni, "Carvedilol Sandoz" 300-550 moni, "Carvedilol Zentiva" - 250-400 moni. "Carvedilol Teva 'utu 200-300 moni," Karvelend "- 170-330 moni," Carvedilol Belmed "- 150-250," Karvetrend "- 170-290 moni.

Hoki te faaineineraa e kore ko te "Carvedilol" utu tohu o te kounga, ahakoa te tarukino kaiwhakanao rongonui ko reira teitei. I roto i te whare hauora nui ngā rerekētanga i waenganui i te utu taero kawemai me te kāinga, moka analogues atu wātea. Kaihaumanu maha māharahara rerekētanga anake te waihanga taketake. Na reira ko te mea e tika ana ki te whiriwhiri i te capsules whānui tino ka e whakaiti i tona gastrotoxicity.

whakaatu analogues kore cheap te mahi haumanu taua, me he whai hua mo te maimoatanga o mate ngakau, me te takawhita. Heoi, ki te mea kua riro i mua i te manawanui etahi kano, ka kia kia mahue ai ki te haere tonu. No te mea i whakamahia e ia ki nga āhuatanga o te puka inenga me nga akiakinga o nohanga hua wē o te whakauru kaha, ka nuku i te hua whakakapinga tona toenga. Na ka kia tumu kitea reira e kore e te tarukino mahi ranei e kore e mahi i rite hiahiatia.

ritenga o te piha haapiiraa

ritenga Class, te oti te nuinga o ngā whakaritenga whakaora hāngai, riro "carvedilol" whakataetae i roto i te maha o tohu. I roto i ngā, i roto i te takawhita ki kia tīpakohia "Bisoprolol" ranei "Nebivolol" ranei. Last, no te mea o tona utu nui e kore e taea te whakamahi e te nuinga o tūroro, ahakoa he mea he tarukino pai. Ki te whakarite tatou katoa cardioselective beta-blockers, ratou piki uara whakaora i roto i te raupapa: ". Nebivolol" "bisoprolol", "metoprolol", "Carvedilol",

"Nebivolol" whakaaro te te maimoatanga pai mo te takawhita, me "Carvedilol" - mo te maimoatanga o CHF. Tetahi o te tahi atu raau taero e kore he pera maha hua i runga i te akoranga o te kore ma'i ngakau rite "Carvedilol." Hoki tenei take, i roto i te huinga ki te diuretic me te inhibitor ACE, he reira e taea ki te whakawhānui i te ora tangata.

"Carvedilol" - ko reira he taero antiarrhythmic whai hua, i roto i nei e taea wa e koe te aroturuki i te whakatinanatanga o te kōpuku AV. He nui hoki tenei fibrillation Atrial, ka kore he wātea te taea o te whakaora i te manawataki me te mau tonu i te reira. i roto i te fibrillation Atrial "Carvedilol" ano whakaritea ki te manawataki mana i roto i te oma-ake ki te cardioversion manawanui.