"Azathioprine": analogues, utu, aratohu me arotake

mate Autoimmune - he rōpū o ngā āhuatanga pathological i roto i nei i reira te nui haere mahi o te pūnaha ārai mate ki tona ake tinana. I roto i te tikanga ki te whakaiti i te whakautu ārai, whakaritea taero e pehi i te pūnaha ārai mate. he mahuinga ia i roto transplantation ki te ārai uhi makanga tenei rōpū o taero. Kia titiro a i te tarukino taua, rite he "Azathioprine" analogs o te raau taero, me ngā tohutohu mō te whakamahi o ona āhuatanga.

kiripuaki pharmacological

I roto i tona wahi o te tarukino "Azathioprine" Kei te whakauru kaha o te taua ingoa. Tenei pūhui matū ko te pärönaki o te matū e tika ana mō te kōtuitui o te DNA me te RNA. I roto i te tinana, azathioprine homai DNA kōtuitanga me, no reira, inhibits tukanga wehenga pūtau i roto i te kopa. Whakaiti i te mahi o te pūnaha ārai mate meinga e te mana o te tarukino "Azathioprine" i roto i te kiko lymphoid.

Ko te kupu i reira ko te inhibition o tukanga wehenga pūtau me te whakautu ārai pūkoro. I muri i te whakataki o "Azathioprine" faaineineraa i roto i te tinana, ko te whakaiti rerekē i roto i te maha o phagocytes me kōtuitui immunoglobulin iti. Kia tātari atu tatou te kōrero: he aha e nga āhuatanga o te "Azathioprine" analogues tarukino, utu, tohutohu hoki te whakamahi.

Pharmacokinetics

Kei te tino tōtika whenumi te tarukino ki te tohanga nahanaha, me tona kukū mōrahi kitea i muri i te 2 anake haora i muri i whakahaere-waha. E kore te mea tino te tarukino Ngā ara ki pūmua wē: tona here ki a ratou ki runga ki te 30%. Hoki te pānga āhuatanga pūkoro tuatahi azathioprine ranei haere tuatahi i roto i te ate.

E haere ana i te hepatocytes, metabolized te tarukino te ki te pūhui hohe - mercaptopurine, me e he pānga pharmacodynamic. Waihanga tata rawa excreted ki ate. Ko te mimi excreted e kore neke atu i te 2% o te medicament.

Tuhinga

E tohua faaineineraa "Azathioprine" analogues ki te taonga kaha taua mo te whakamahi i roto i te transplantation ki te ārai tauhohenga makanga uhi.

Ano, Kei te tōtika te whakamahi i te raau taero i roto i te mahi rheumatological ki te hamani kaikōiwi me mate autoimmune pērā i kakā, erythematosus lupus pūnahanaha, psoriasis, te purapura thrombocytopenic, pemphigus, me te tini ke atu.

contraindications

contraindicated Drug "Azathioprine" Kei roto i te tūroro ki te hypersensitivity ki te wae tarukino. Nā ki te meka e inhibits te tarukino nga iroriki katoa o te toto, contraindicated "Azathioprine" Kei roto i mate o te toto (anemia leykotsito- me lymphopenia, thrombocytopenia), me te hapu me te mea ngote u.

Whakamahia i roto i te hapū, me te uma-kai

haere te taonga kaha ki te waiu, uma me te roto i arai gematoplatsentarny. I roto i tenei whakaaro, e kore te te whakamahi tūtohutia i roto i te hapu, me te uma-kai. Ki te tika, he tika te whakarite o te tarukino ranei ona analogues i roto i tēnei kāwai o tangata ki te aromatawai i te mōrea i te whakamahi o te whakamahi o te raau taero, me te kino pea ki te whaea, me te kukune. A, no te faaue āpiha i roto i te whāngai ū tata ki te whakakore.

Āhuatanga o te tono

Ko te tarukino me ona analogs Me ki kia whakamahia ki te tūpato i roto i te tūroro e mate ana i koroputa hei, a i roto i te tūroro ki te hē o te xanthine oxidase.

pānga taha

Ko te rōpū matua o te pānga taha e pā ana ki inhibition o wheua wheua mahi, kawenga hoki te hanga o ngā pūtau toto whero. I roto i te tono analogs kei roto azathioprine, he hua i roto i te rahi o ngā pūtau i roto i te toto, whakaiti o tatau ngenimā, tatau mōtepe, anemia.

Hoki wāhanga o te wahi kūnatu nga pānga taha tino noa ngā: heke hiahia, disorders kumete, waimaero mahi ate, pāpaka ulcerative o te wahi gastrointestinal. mate pea o hepatocytes, aru e te hua i roto i te bilirubin atu whakamātautau ate mahi ranei. I roto i te tūroro pangia pokanga mō huaranga whēkau me te kikokiko kia whakawhanake pancreatitis, pāpaka ulcerative o te puku, ngā whēkau, te whanaketanga o te kakā paitini.

rawa uaua tauhohe mate pāwera puta ka whakahaere tarukino "Azathioprine" analogs i runga i taua mea (hei tauira, "Azathioprine"). Faaiteraa kore whakahuatia, te nuinga e tika ana ki te ponana kiri āhua ngau kino ranei.

I roto i te tahi atu ngā pānga taha kia tuhia te whanaketanga o ngā tukanga hopuhopu tuarua i roto i te tinana, te ahua o te mamae uaua, me te tahi, whakapeka iti hoki mahi tākihi. I roto i te tahi mau take kino, te tarukino "Azathioprine" analogues ki te taonga kaha taua taea meinga anemia hemolytic, hoatu tohu i te pūnaha io pokapū. Azathioprine rite te taonga kaha pharmaceutically, he wahi o te taua tarukino ingoa me ona analogues, kua he mana korerotia i runga i te kukune (pānga teratogenic me mutagenic) me ahei o whakapataritari te ahua o ngā tukanga puku, me ratou repara muri. Ko te kupu, ko te mea e tika ana ki te titiro i te whakarite o te tarukino "Azathioprine" (papa) arotake, ngā whakaahuatanga, analogues tarukino me te whiriwhiri i te tātai tika. Titiro mua, mōhio tatou e rite te azathioprine whakauru kaha puai hua i runga i te akoranga o te mate, kia rite ki tohu. tohua ana tēnei te kore anake rata, engari ano hoki tūroro ratou.

"Azathioprine" - taurite, analogs

Azathioprine - ahurei i roto i tona ara ake he taonga he mahi immunosuppressive. I roto i te tirohanga o te mākete ho'oraa kore he tino taka pai māngai kei roto azathioprine. Analogs "azathioprine" taea te aroaro i roto i te raau taua, rite he "Azathioprine".

E wātea ana i roto i te puka papa ki te ihirangi rite azathioprine te tarukino. Ko te mita anake ko te utu o "Azathioprine" o te raau taero, e taea i roto i 4-5 wa te utu o "azathioprine" production Russian.

Paihana me te tuwhena rawa

Drug tuwhena rawa "Azathioprine" me ona tauira "Azathioprine" whakakitea disorders o te wahi gastrointestinal, pehanga o te wheua wheua mahi, me te nui haere whakamātautau mahi ate. maimoatanga paihana rite te tarukino iho me ona analogues he symptomatic, e hāngai ana ki te whakakorenga ohorere o te raau taero i te tinana. No raau motuhake. E whai hua i roto i te wahi tikanga tātari detoxification no te mea e kore te taonga kaha i roto i a ratou excreted rawa.

Ara

E kore e te tarukino me ona analogs tūtohutia hoki te whakamahi wā roa-. I te timatanga o te maimoatanga titau aroturuki tamau o te pūtau o toto piringa, me te aroturuki o whākōkī ate.

I roto i te heke mai, te mana ia o te poroporoaki, te whakahaere rangahau aroturuki kotahi, e rua i te marama.

mutunga

Ko te tarukino me ona analogs kia tautapa anake te mātanga mātanga. I mua i te tango i te tikanga e tika ana ki te mamae i te whakamātautau tonu, me te whakahaere pea tiaki therapy. Mō ētahi atu pārongo, ka taea te whakarite o "Azathioprine" teuteu tohutohu mō te whakamahi. Utu, analogues o tenei taputapu hei wāhanga o te poipoi o tūroro. Ko te kupu, Ko te utu iti o papa 50 i roto i te rohe o 250-300 moni, a ka whakahuatia e pā ana ki analogues i runga ake. I mua i te tango me paunatia koe te "AtAKi" me "raruraru" ka timata maimoatanga.