Anticoagulants mahi hāngai, me te autaki. anticoagulants autaki: te rārangi o raau taero, te huarahi o te mahi, whakarōpū. anticoagulants autaki tuwhena rawa

Ki te mahi tika o ngā pūnaha coagulation me toto antisvertyvayuschey māori o te toenga ā-o te tinana. e kore e toto rere i roto i nga oko i ārai me ngā herenga, me thrombus hanganga i te taumata tika. A, no te ohorere te toenga kei te mahi o ngā pūnaha i manakohia o te faaitoitoraa o coagulation toto, i reira he tikanga e taea arahi ki te hanganga nui o clots. anticoagulants autaki - tetahi o nga rōpū o te raau taero e whakamahia ana mo te ora o disorders ā-.

He aha e anticoagulants?

Anticoagulant huaina moni, e whai pānga anticoagulant me whakahohetia te waimehatanga o te toto. Tenei taea ki a koe whakahoki i te āhuatanga rheological, me te whakaiti i Thrombosis.

E wātea ana i roto i te puka papa Founga, rite hinu, hāpiapia me taka werohia. E faataahia ratou kore anake mō te rongoā mate, engari ano hoki ki te ārai i nui ake te hanganga o clots toto.

Nuinga o ngā mema o tenei rōpū o taero e kore e hanga e thrombus, me mahi upoo-. Ko te tukanga o te te rongo ki ngā āhuatanga wē, me te hanga o te thrombin, e pōturi iho clots toto.

E wehea Drugs ki e rua ngā rōpū rite ki o ratou mahi:

• anticoagulants tika;
• anticoagulants autaki.

mahi tika o taero e hāngai ana heparin-

Tenei rōpū o moni he pānga tika i runga i te cofactors wē e tautāwhi i thrombin. Ko te māngai matua he heparin. I runga i tenei pūtake i reira ko te maha o taero mahi rite, me te orokati ki te ingoa:

• "Ardeparin".
• "Nadroparin."
• "Klivarin".
• "Longiparin".
• "Sandoparin".

Heparin pärönaki ranei herea ki antithrombin-III, e arata'i ki te huringa i roto i te wāhi o ona muingota. Tenei tere ake te hononga o te cofactor mo thrombin, a ka ki te Tautauā te tukanga upoo-.

Āhuatanga o te tono "heparin"

matū Mahi e hāngai ana te ārai i te tupu me te horapa o te katinga toto. Heparin rāpoi ki te hanga i te matatini ki antithrombin, i te mea he inhibitor o āhuatanga coagulation. Ko te taonga, ko te he mekameka glycosaminoglycan. patia i te tarukino te subcutaneously me haamata tona mahi i muri i o haora i te tokorua.

Ki te whakahaerea tika, mahi tere "Heparin" whaowhia pâmuhia ki te whakatere mahi, me te whakapiki ake i bioavailability. Ko te kōwhiringa o te rongoā inenga tei runga i te āhua i roto i i kei te manawanui te. Ano, tangohia ki pūkete te aroaro o mate rere, whakahaere whakarara o ētahi atu rōpū o medicaments, te hiahia mō ngā tukanga hāparapara i runga i oko.

oligopeptides

Rongoā e mahi tika i runga i te pokapū o te thrombin whakahohenga, e whakaaro kaha inhibitors motuhake o te pūnaha Thrombosis. Ko te whakauru mātātoa o te tarukino i runga i to ratou ake te hono ki te āhuatanga upoo-, te huri o ratou conformation.

Tenei rongoā "inogatran", "Hirudin", "Efegatran", "Tromstop" me etahi atu. Whakamahia ki te ārai i whakaeke ngakau o angina, mate tētere, mo te ārai o thromboembolism, reocclusion i roto i angioplasty.

anticoagulants autaki (rārangi)

Kua te anticoagulant tuatahi kua riro i roto i te rau tau XX i roto i te United States, ka i kitea ai he mate hou o kau, whakapataritari toto taimaha. Kua A, no te mea kua elucidated te take huru pathological, whakamatauria reira e i roto i te kararehe huaketo ki pokepokea ai mahi, kei roto i te whāngai clover. Mai i tenei rauemi raw i synthesized e te antiplatelet tarukino tuatahi mahi autaki - "Dicoumarol".

Ki te rā, te rārangi o ngā rawa e he analogs o ngā tūemi neke atu i te kotahi rau. enei taero katoa o - anticoagulants-waha. Ko te tikanga o te mahi o te rōpū o te raau taero e hāngai ana i runga i inhibition o te mahi o te huaora K.

He ua tuli āhuatanga e whakawhirinaki i runga i tenei huaora. anticoagulants autaki tautāwhi i te faaitoitoraa o te pūmua coagulation me cofactors vitaminozavisimyh. Kei te rāhuitia te whakamahi whakakeke o enei taero, rite kei te piki haere te mōrea o toto pōauautanga.

E rua ngā rōpū matua, e kua wehea anticoagulants autaki katoa. hāngai Whakarōpū o moni i runga i matū kaha ngā i roto i te faaineineraa. wehewehe:

• pärönaki coumarin;
• hāngai indandiona taputapu.

taka indandiona

I muri e mau ana i roto i te maha nui o rangahau, i kitea pūtaiao e kore e whakamahi i nga hua i runga i tenei taonga kaha i roto i te therapy. he maha nui o ngā pānga taha rite tauhohe mate pāwera nga formulations i. Ko te whai huatanga o te pānga i runga i te pūnaha protivosvertyvaniya kihai ano i whakaatu hua ōrite.

Tenei rōpū o taero ngā raau taero, "phenindione", "Difenindion", "Anisindion". I whakaritea e te reira ki te aukati i te pai rawa tuatahi mo te rōpū tuarua o āpiha antiplatelet me o pärönaki indandiona tēnei wā whakamahia "Fenilin" anake.

Te raau e te utu iti, he mea e wātea ana i roto i te puka papa. Tika mō te 10 haora, a he mea tino nui ki te mau tonu i te roanga e hiahiatia ana o therapy. tutuki ana te pānga kei muri anake 24 haora i te wa te horopeta tuatahi. Taupānga puta i te tikanga o te aroturuki i te huru o te manawanui mā te toto o ngā tawhā taiwhanga (coagulation, whakamātautau whānui, matūora).

Ko te kaupapa o te 'fenilina ":

1. Ko te ra tuatahi - 1 papa 4 wā.
2. rua o nga ra - 1 papa 3 ngā wā.
3. Ko te toenga o te maimoatanga - 1 papa ia ra.

kia rongoā kia tangohia ki ngā rongoā e whakaiti i te taumata o te kūhuka i te tinana.

pärönaki coumarin

Coumarin - he taonga i te mea i roto i te tipu, me te taea te hua synthetically i te taiwhanga. Tuatahi, i muri i tona tango, i whakamahia te taputapu rite te paihana mo te mana kiore. timata te wahi anake o te wā ki te tono i te tarukino ki te mahi ki Thrombosis nui.

Anticoagulants o te mahi autaki - teuteu e hāngai ana i runga i coumarin - kanohi e nga tikanga e whai ake nei o te rongoā:

• "Fafati" (ona analogues - "Marevan" "Sodium fafati", "Varfareks").
• "Atsenokumarola" (orotahi - "Sinkumar").
• "Neodikumarina" (orotahi - "Etilbiskumatsetat").

"Fafati": āhuatanga tono

Anticoagulants o mahi autaki (ko e wātea ana te rārangi i roto i te tuhinga) Kei te tino maha kanohi e "fafati". Tenei te tikanga tableted, hangaia e 2.5, 3 5 ranei mg. Pānga i runga i kaiao tangata whakawhanake i muri i 1.5-3 ra i muri i te whakahaere tuatahi o te papa. pānga mōrahi i te mutunga o te wiki tuatahi.

I muri tango i te raau taero hoki nga tawhā rheological o toto ki noa i muri ra 5 i te rā o te whakakorenga "o warfarin." whakamahia Founga 2 nga wa i te ra, i te kotahi me te wa ano. I te 5 o nga ra o te therapy e arowhai tawhā toto ki te whakatau i te whai huanga me te aonga.

whiriwhiri te akoranga o te maimoatanga te mātanga i roto i ia take takitahi. āhua mate etahi (hei tauira, fibrillation Atrial) rapua e tono tonu. Ki te whanaketanga o PE (Pulmonary Embolism) kore te antiplatelet kaihoko whakaritea hoki iti iho i te ono marama mo te ora ranei.

A, no te ki te hiahia mō te wawaotanga hāparapara "fafati" whakakore 5 ra i mua ki te pokanga. Tenei ka tukua hoki te kuputohu toto ki noa. Ki te hiahia nui mō te whakamahi tonu o therapy anticoagulant, whakakapia te taputapu te heparin unfractionated. I whakahaere te horopeta whakamutunga 4 haora i mua ki te wawaotanga.

I muri i te mahi i roto i te 4 chasa anō i taki heparin unfractionated. Ka taea te hoki mai te fariiraa i autaki māngai antiplatelet i rua ra, i muri i te āhua o te toto aroturuki ki te awhina o whakamātautau taiwhanga.

I roto i nei whakamahia take ko anticoagulants?

anticoagulant Direct me autaki whakamahia mo te ārai o thromboembolism, Thrombosis whakapeka o te pūnaha venous i roto i te hui o te aunoa vaolo ngakau prosthetic me fibrillation Atrial.

Ko te mate matua i roto i te whanaketanga o e kua whakaritea anticoagulants hāngai, me te mahi autaki, i te wehenga e whai ake nei ki ngā rōpū:

1. Thrombosis o te pūnaha matua:
   • infarction myocardial;
   • Embolism pūkahukahu;
   • patunga ki tohumate o ischemia;
   • whara pāmamae ki pera ki atherosclerosis.
2. Tohatohaina coagulation intravascular :
   • paorooro āhua;
   • whara pāmamae;
   • te whanaketanga o te sepsis.
3. Thrombosis whakapeka o nga uaua e:
   • clots toto i roto i te papamuri o uaua tīponapona;
   • thrombosing plexus venous hemorrhoidal;
   • katinga i roto i te iahoki vena cava iho.

contraindications matua

anticoagulants autaki - taero e e tino rāhuitia i roto i te aroaro o te hē reihuka, malabsorption o te kūhuka me galactose. He he maha o taero i te taua wa e kore e taea e koe te whakamahi i anticoagulants-waha. Rārangi o raau taero arā, o taero nonsteroidal anti-inflammatory, "ahipirini", "Dipyridamole", "clopidogrel", "rongoā paturopi", "Chloramphenicol", "Cimetidine".

Here e kore e taea te whakamahi anticoagulants hāngai, me te mahi autaki:

• mate ulcerative o te wahi gastrointestinal;
• aneurysm iaia;
• mate ate;
• toto whakapeka;
• thrombocytopenia;
• täkihi;
• huatū ahau a muri marama o haputanga;
• taumata teitei o te creatinine.

pānga te taha o āpiha antiplatelet

Ia o nga raau taero i roto i tenei rōpū o māngai he pānga taha rite. faaite mai ratou ia ratou i roto i whaiaro ranei horopeta ta'etotonu ranei takahi i runga i te whakamahi o ngā tūtohutanga.

pānga te taha ngā te whanaketanga o te toto, tohu dyspeptic rite ruaki, whakapairuaki, me te korere. He he he mamae puku kaha, ponana kiri mate pāwera i runga i te momo o pununga honé katoatia ranei. Kia whakawhanake necrosis, makawe mate, minamina kiri.

I mua i te tīmata maimoatanga, me te manawanui haere te raupapa o ngā whakamātautau ki te whakatau mehemea ki te whakamahi i enei taero. Te manawanui homai e te tatau oti toto, mataora, urinalysis, mimi i runga i Nechiporenko, coagulation. Kei te tūtohutia hoki te reira ki te hanga i te whakamātautau ultrasound o nga whatukuhu, me te haere nohoanga mo te toto tipua.

anticoagulants autaki tuwhena rawa

He tino onge overdoses o tenei rōpū o taero. Tenei e taea tupu ki te ka whare te tamaiti iti i te tarukino me te tamata i te reira no te reka. Tikanga, Ko iti te kukū o te taonga, na kihai i nga papa horopeta kotahi wehi. I roto i te take o te whakamahi motuhake whanga ranei o pota nui o te taonga e taea te whakawhanake i tētahi coagulopathy me te toto.

e kore tohu motuhake, na imi te mea i tupu inu nui o te raau taero whare hauora tuwhena rawa, he uaua. Tohutanga faaiteraa rite ki tini o nga mate, me āhua pathological o te rauropi. He te manawanui:

• karawarawa marama i runga i te kiri;
• toto i roto i te mimi feces ranei;
• uterine toto;
• kanokanototo i roto i te kaki;
• toto intracranial.

I mua, patunga o mua, tūroro kaumātua, toto gastrointestinal me te hītori o te hematocrit iti - e pā ana ngā āhuatanga e taea te whakaiti i te susceptibility o te kukū paepae o taero.

tuwhena rawa therapy Antiplatelet

1. Horoia ngahau i roto i te puku te hāora i muri i te mea kahore tikanga whakahaere o raau taero ranei.
2. hoatu te manawanui te waro whakahohe hoki absorption intestinal.
3. "Cholestyramine" roto faaterehia i roto i te take o te tuwhena rawa "warfarin" ona analogues ranei.
4. whakanohoia ana te manawanui kei roto i ngā āhuatanga antitravmaticheskie, ki te karo i te putanga o hematomas hou me pakaruhanga toto.
5. Ki te mate toto nui huhu ranei i hanga wē kawea āhuatanga, i ētahi wā toto katoa. Pai i roto i te whakamahi o Kikī pūtau toto whero, cryoprecipitate, prothrombin matatini.
6. Whakaritea "Phytomenadione" hua e hāngai ana i runga i huaora K.
7. Ki te tika, tautapa kahore therapy antiplatelet, te tarukino "Phytomenadione" whakaritea te akoranga o te maimoatanga, pai atu i rite ki te āwhina tuatahi.

Ki te hoki huru o te manawanui ki noa, engari he mea e tika ana ki te haere tonu ki te whakamahi i anticoagulants waha, he mea e tika ana ki te "fafati" whakakapi poto taero heparin raupapa.

mutunga

Ko te whakamahi o raau taero antiplatelet kore anake e taea haerenga toto paerewa rheological, engari ano hoki ki te whakapai ake i te huru whānui o te manawanui, me te ārai i te whanaketanga o mate nui.

aro tupato ki te whakamahi o anticoagulants, te whiriwhiri o te inenga me te aroturuki huru o te manawanui e taea te āwhina whakaiti i te mōrea o pōauautanga me te angitu. Ngaio e whakamahi i tēnei rōpū o raau taero i roto i to ratou mahi, he tika ki te whakapai ake i te matauranga, me te ki te ū tino ki tūtohutanga hauora ao.