Kua riro hua pai o te whakamātautau o te tarukino hou mō te kanisā Scientists

Kua whakahaere Scientists ki te waihanga i tētahi rongoa mo e kanisā, i whakamatauria kotahi ano ki te kia whai hua. I roto i te mau tamataraa haumanu whakakitea e te puku i roto i 71% o tūroro ki kāpeka kanisā heke noa tino ngaro ranei.

rōpū High-mōrea

Te ako, ko tona hua i whakaputaina i roto i te Journal o Haumanu Oncology, whakahaere ki te whai wāhitanga o te 24 tūroro ki kanisā lymphocytic ma'i hoki nei kua whai hua atu maimoatanga. Ko te tau o tūroro hora i 40 ki te 73 tau. I tua atu, ki te whai wāhi i roto i te ako riro ia i te toharite o ngā momo rerekē e rima o therapy, tae atu i te maimoatanga o "Ibrutinib" - he tarukino whakamahia whānuitia ki tenei momo o te mate pukupuku. Tenei hoatu kaiuru i mōrearea tiketike ki te auau oranga iti.

mau tamataraa haumanu

He rōpū i te Research Centre Freda Hatchinsona Cancer whakamahia maimoatanga wawe i huaina immunotherapy timoralnogo receptor (CAR). Ki tenei momo o te therapy, ake pūtau T o te manawanui tangohia i te toto, a ka puta ke i roto i ngā āhuatanga taiwhanga. I roto i tenei take, kua whakarerekētia e ratou ki te mohio ki CD19 - antigen i runga i te mata o ngā pūtau mate pukupuku.

Na, kua patia enei pūtau whakarerekētia hoki ki te manawanui, meinga ki a ratou te whawhai ki kanisā, me hopu hoki whakanuia pūtau mate pukupuku ki te antigen CD19. pūrongo nga kairangahau e i muri nga marama e ono me te hawhe i te 17 o te 24 tūroro heke te puku tino ngaro ranei.

"E kore mua i mohiotia ai ranei e taea ki te whakamahi i immunotherapy timoralnogo pūtau receptor T mo te maimoatanga o te tūroro ki te kanisā lymphocytic ma'i, e no hoki ki te rōpū nui-mōrea - mea kaituhi mata o te ako Dr. Cameron Turtle, kairangahau immunotherapy i te Fred Hutchinson Center. - E whakaatu ana to tatou ako e te pūtau CAR T ko te maimoatanga tino whaihua mō ngā tūroro ki CLL kore e nei maimoatanga hāngai "Ibrutinib '."

He aha te mea CLL?

kanisā ma'i lymphocytic - he mate e tīmata i roto i te hinu wheua wheua o tangata (i roto i te kiko ngohengohe roto wheua i reira e hanga e ngā pūtau toto). I roto i te tūroro ki CLL, hua te hinu wheua wheua maha rawa lymphocytes rerekē (momo rerekē o ngā pūtau ma toto).

Ka rite ki te mate kauneke, e taea te whakarōpū tahi enei pūtau rerekē, me te tupu i roto i te waitinana kōpuku, kōateate me te ate. taea ana te ruri te rahi o taua "puku lymphoid" te whakamahi i ngā momo o te matawai.

pūtau hauora - ko pūtau ārai o te tinana e te tauturu i te whawhai mate, engari i roto i ngā tūroro ki CLL, e kore e mahi ratou tika, ka meinga te hepohepo. E ai ki te American Cancer Society, ma'i kanisā lymphocytic i roto i 2017 ka hei te take o 4660 mate. tūmanakohia hoki ki te kia e pā ana ki 20.110 take hou o te mate.

pānga taha

He therapy New pānga taha nui, ahakoa he te nuinga o ratou reversible. I roto i te ako e pā ana ki 83% o tūroro whakamatauria cytokine tuku syndrome, ko te pōauautanga noa i muri maimoatanga T-pūtau ki ngā tohu pēnei i te kirika, whakapairuaki, Chills, me te pēhanga toto ohoreretia iti. Kia aroha mai, i falemahaki e rua o nga tūroro, me tetahi mate i roto i te maimoatanga.

E whā wiki i muri i te maimoatanga, tātarihia te kairangahau wheua tauira wheua o 12 tūroro, e tika ana ki te maimoatanga i roto i te murunga, kia kite ranei noho reira he āhua i muri i te otinga o te therapy. O enei, ko e whitu kahore pūtau mate pukupuku mārere.

Ko te ako tonu i roto i ona tīmatanga, engari kua kua nui opuaraa. He pānga te taha tino he raruraru, engari nga painga pea tino nui ratou.