Ko te tarukino "Doxorubicin": ako ā-, arotake, whakaahua, puka tuku, inenga, rokiroki. "Doxorubicin-Lance": tohutohu mō te whakamahi

Ko te tino mōrearea ki te ora te tangata i te mate pukupuku. Kei a ia ko ngā pūtau proliferating mārere me tutu, e e taea ki te tomo ki roto ki te kikokiko e karapoti ana, ka metastasize ki ētahi atu whēkau.

Ko te whanaketanga o taero me maimoatanga mō taua mate ko te mahi nui. Kia aroha mai, a mohoa noa nei e kore i whakaritea e kore tetahi noa te mutunga, me te ahau. Ahakoa i reira e tonu taero e taea pōturi te wehenga o ngā pūtau puku. Ko tētahi o ratou tuku rongoā "Doxorubicin". Ka hipokina tohutohu mō te whakamahi, me te whakaahua o te raau taero i roto i tenei tuhinga. tikanga i roto i reira e kitea e koe ngā mōhiohio e pā ana ki te āhua o ki te pupuri i mea i roto i nei hanga ko reira e wātea ana mō te hoko, me te ake.

Packaging, hanganga, te āhua me te whakaahuatanga

I roto i te mea puka hokona te "Doxorubicin"? Tohutohu mō te whakamahi tohu nga momo e whai ake nei o te hua:

• Lyophilizate mō te faaineineraa o te otinga mō te werohia intravascular me intravesical. Ko te reira i te papatipu maiengi whero-kōwhai me te kei te taonga kaha pērā i doxorubicin hydrochloride. Ka rite ki atu kai mā te whakamahi i mannitol. Rongoā e hokona i roto i nga ipu, kopakia ana i roto i te pouaka pepa.
• Aro hoki te whakaputa i te otinga mō te werohia intravascular me intravesical. Ko te wai whero, me te mārama kei roto doxorubicin hydrochloride me he wātea i roto i ipu me kātene.

Ko te Pūtaiao o te tarukino

He aha te mea tenei rongoa rite "Doxorubicin"? Tohutohu mō te (puka tuku o te tarukino i tohua i runga ake) te whakamahi pūrongo e ko te reira he anthracycline paturopi anti-puku, i tawhiti i ahurea o te harore Streptomyces peucetius. Ko te taea ki te faaitoito pānga antimitotic me antiproliferative ia.

Taunekeneke ki DNA, inhibits te medicament RNA polymerase, polymerase DNA me te topoisomerase momo 2, a hoki whakahohetia te hanga o Radicals free, me te mahi i runga i te taiepa pūtau. Ka rite ki te hua o taua pānga pōturi tukuruatanga DNA me te koiora te kōtuitanga waikawa karihi.

E kore e taea e kore ki te mōhio i te meka e whakaaro tatou te tikanga he pānga cytotoxic tika. whakaatu i te pūtau he tūtohutanga ngā ki te tarukino i roto i te G2-wāhanga, me te S-wāhanga o ratou ora.

āhuatanga nekeneke

He aha nekeneke tawhā tūturu i roto i te tarukino "Doxorubicin"? kī Tohutohu mō te whakamahi i muri i werohia rō-uaua, wehea tonu te taputapu multiphase. I roto i te 5 meneti tuatahi o te medicament riro tere kiko, me ona kukū i roto i te toto heke tere. Ko te rua o nga wāhanga, kua kawea te reira i roto i ngā rāpoi ngota tarukino puhoi i te kopa.

Aro tarukino kaha i roto i te ate, whatukuhu, kōateate, pūkahukahu me te myocardium. Reira ô hoki te ewe me te excreted ki te waiu uma.

Response ki pūmua wē puta i 75%. Pākia o raau taero i roto i te ate, ai hanga he pārōnaki hohe pērā i doxorubicinol.

I roto i te whakaiti o Radicals free taea kōtuitanga whākōkī pā te whanaketanga o te tāoke cardiac.

Hawhe-ora o te doxorubicin me doxorubicinol rite, me he pā ana ki 20-48 haora.

tukua Tata 40% o te horopeta o te tarukino te tahi i te ate, me% 6-11 anake o doxorubicin me ona pärönaki, hoki kei te kitea 5 ra i roto i te mimi.

Tuhinga

tarukino "Doxorubicin" kia whakaritea i te mea mate?

Tohutohu mō te whakamahi (hoki pukupuku tōngāmimi ko te taputapu e whakamahia ana rawa maha) kī reira e te rongoā mahi pai, no te:

• mate pukupuku repe thyroid, sarcoma o Kaposi me Ewing;
• Wilms 'puku, mate pukupuku pekitīlia, puka pūtau iti o te mate pukupuku pūkahukahu;
• insulinoma, mate pukupuku uma, mesothelioma;
• mate pukupuku esophageal, carcinoid, neuroblastoma;
• sarcoma osteogenic, mate pukupuku hepatocellular tuatahi, lymphoma kore-Hodgkin o ;
• Cancer o te repe repeure, mate pukupuku o te matenga, me te kaki, thymoma mārere;
• pukupuku i te waha, etahi momo o pukupuku testicular;
• uterine sarcoma, mate pukupuku endometrial, mate o Hodgkin;
• rhabdomyosarcoma, kanisā whakapeka;
• kanisā lymphocytic ma'i, myeloma maha.

contraindications

He aha e te huru o te whakahau manawanui riria ia te tarukino "Doxorubicin"? Tohutohu mō te whakamahi, oncologists tūturu mea e kore te taputapu akapapu rawa whai hua i roto i:

• sensitization ki doxorubicin atu matū tarukino, me te māngai o anthracyclines me anthracenediones ranei;
• therapy mua, ranei te tahi atu i te mau melo o te anthracenediones anthracycline i whāiti pota, me te kore ate (nui), infarction myocardial, arrhythmias, whakapeka mate viral me kore ngakau (mō te whakahaere rō-uaua);
• pukupuku mārere, germinating i te taiepa o te tōngāmimi, te mate mimi me te cystitis (mo intravesical).

Ki te tūpato tino, kia whakamahia tenei tarukino mō te iwi nei riro hahau kaha, me te te āhuatanga mōrearea mō te cardiotoxicity, takahi o te ate, wheua wheua kookuhutanga o nga pūtau mate pukupuku, me te mōmona.

I tua atu, āta whakaaro whakaritea te tarukino te mō ngā tamariki me te tangata o te tau matatau, a hei wāhanga o te maha-momo me te therapy antitumor multicomponent.

Drug "Doxorubicin": tohutohu mō te whakamahi, inenga

E ai ki nga tohutohu, whakaaro taea te whakahaere te raau intraarterially, e pâmuhia me intravesically. Me mahara hoki käore te reira e ka tenei taputapu e whakamahia putawa, ranei i roto i ngā ki ētahi atu taero cytostatic i roto i toketaá rerekē.

Houtia otinga tarukino "Doxorubicin" ko ki te whakamahi tonu i muri i tona hanga.

waihanga i werohia rō-uaua

I te inenga tūtohutia o monotherapy "Doxorubicin" ia huringa ko 60-75 mg / sq. m katoa e toru wiki. Tikanga, patia te tarukino te kotahi. Heoi, kia kia whakahaerea tenei horopeta me mo werohanga maha (i roto i te nui o 25-30 mg / sq. M ia ra mo te 3 ra tuatahi o te huringa).

Ki te whakaiti i te pānga paitini o te tikanga i whakamahia whakahaere wiki o 10-20 mg / sq. wā m te wiki.

A, no te ngā ki ētahi atu āpiha anticancer whakahaere medicament kaha i roto i te huringa inenga i roto i te nui o 30-60 mg / sq. m nga 4 wiki.

kawea akoranga toutou o te maimoatanga i muri anake i te whakakorenga o tohu katoa o te tāoke.

Ko te katoa horopeta o te tarukino kore e waiho atu atu i 550 mg / sq. m.

whakahaere kōtuitui-matua o te kaihoko

Kia pehea te ko te werohanga kōtuitui-matua "Doxorubicin" tarukino? Ārahi āhua e ki te whakarato i te iwi sidetone ki hepatocellular mate pukupuku medicament kaha ki te kia whakahaerea ki te iatuku ate noa i roto i te inenga o te 35-150 mg / sq. m. I te wā wa taua i waenganui i huringa kia rite i 3 wiki ki te 3 marama.

Ko te kupu whakataki o te tarukino ki te tōngāmimi

Ka rite ki te tōngāmimi patia tarukino "Doxorubicin-Teva"? Tohutohu mō te whakamahi pūrongo e te tikanga tenei inenga hoki kia whakahaere intravesical 35-50 mg ia tāutanga.

Me kawea ngā tukanga Medical i roto i wā o 7-28 ra, i runga i te whakaaro (ārai maimoatanga ranei) rānei.

kia kukū o te otinga tarukino 1 mg / 1 otinga wai ml tinana ranei.

whakamana Instillation te i roto i te 2 haora. I te mutunga o te manawanui kia noho tahanga te tōngāmimi.

pānga taha

Te faaineineraa "Doxorubicin", i whakaahuatia ana i runga i te ako kia meinga i te tauhohe taha e whai ake:

• ruaki, te mamae puku, whakapairuaki, colitis, stomatitis, korere, esophagitis, kōrero hyperpigmentation mucosa, anorexia, nui haere bilirubin kukū i roto i te toto, toto gastrointestinal, nui haere transaminases ate;
• horopeta-ti'aturi leukopenia reversible, thrombocytopenia, anemia, leukopenia, neutropenia;
• tachycardia pakohu, poraka atrioventricular, puka tachyarrhythmia kore congestive ngakau, bradycardia, thrombophlebitis, tana poraka peka paihere, abnormalities i runga i ECG, arrythmia ventricular, Embolism pūkahukahu, phlebitis, pōauautanga thromboembolic;
• amenorrhea, oligospermia, hyperuricemia, poke mimi whero, azoospermia;
• pīkaru, keratitis, lacrimation;
• piringa neurotoxicity, hukihuki, pōroa;
• edema, alopecia reversible, photosensitivity, hyperpigmentation kiri, hikaka, minamina, mamae kino, hikaka, erythema, kiriwaho hou;
• dermatitis, hikaka, bronchospasm, Makere kiri, anaphylaxis;
• phlebitis Local, mumura tohua, fleboskleroz, thrombophlebitis, mamae rohe, kiko necrosis;
• polyuria, nocturia, dysuria, necrosis o nga kiriuhi tōngāmimi, hematuria, hūhi, urination mamae;
• striation erythematous i te wāhi i werohia;
• rohirohi, ahuatanga, kirika, Chills, te whanaketanga o te lymphocytic ranei kanisā myelocytic (whakapeka), hyperuricemia, tai, nephropathy;
• whewhe 12 duodenal / pekitīlia, sclerosis biliary.

tohu o te tuwhena rawa

He aha e nga tohu o te tuwhena rawa anoo, ina whakamahi koe i te maha nui o "Doxorubicin" tarukino? E whakakitea Tohutohu mo Whakamahi āhua e he tuwhena rawa o nga moni e taea arahi ki tohu paitini e te pūnaha kūnatu, me te i roto i te myelosuppression nui. I tua atu, pota teitei o te tarukino e taea e rawa ngāwari ki te meinga mate ngakau whakapeka.

e kore e He raau ki te tarukino "Doxorubicin" te tīariari. I roto i te tuwhena rawa i pāngia faaterehia therapy symptomatic. Hoki, kua falemahaki reira me e tukinotia ki taero antibacterial.

taunekeneke tarukino

He reira taea ki te ngā i te tahi atu raau taero tarukino "Doxorubicin"? Tohutohu mō te whakamahi whakaatu e ina whakamahi koe i tenei taputapu i roto i ngā ki ētahi atu taero cytotoxic maha whakakitea ratou tāoke tāpiri.

A, no te he tarukino i ngā ki ētahi atu taero cytotoxic, e whai cardiotoxicity (hei tauira, "fu" ranei "Cyclophosphamide"), titau aroturuki tupato o te ngakau te akoranga katoa o te therapy i roto i.

"Streptozocin" faarahi te hawhe-ora "Doxorubicin".

Ko te therapy "Doxorubicin" kia whakaatu i te manawanui tohu o cystitis hemorrhagic whakapeka i muri i maimoatanga "cyclophosphamide", me te tūkino i te āhuatanga o te ate te tāoke i muri i maimoatanga "mercaptopurine."

Ko te whakamahi o "Paclitaxel" i mua i te introduction tūturu o "Doxorubicin" kia whakapataritari he hua i roto i te kukū toto o te muri.

He aha taero E rāhuitia i te whakamahi i tarukino "Doxorubicin"? Tohutohu mō te whakamahi (e kore hoki te kararehe e faataahia) pūrongo e kore kia konatunatua tenei taputapu ki ētahi atu taero. Hei tauira, ko reira pharmaceutically hototahi ki te "heparin", "Dexamethasone", te konutai succinate, "hydrocortisone", "cephalothin", "aminophylline", "fu" me ētahi atu raau taero anticancer.

A, no te ngā ki kano viral ora he taea tukuruatanga viral me nui haere tauhohe taha, me te whakaiti i antibody kōtuitui i roto i te tinana o te manawanui i roto i whakautu ki te whakamahi o kano.

tūtohutanga Motuhake i runga i te whakamahi o te raau taero

He aha kia mohio koutou i mua i te whakamahi i te "Doxorubicin-Lance"? Tohutohu mō te whakamahi tohu e i roto i te akoranga o te maimoatanga āpiha antineoplastic tika ki te kawe i roto i te aroturuki auau o ate mahi, te pikitia o piringa toto, ECG me te ultrasound o te ngakau.

hoko tikanga, tikanga o te rokiroki me te papa-ora

Hea kia te tarukino "Doxorubicin-Lance"? Tohutohu mō te whakamahi pūrongo e me pupuri i tenei taputapu i roto i te wahi maroke, me te pouri te wahi e kore e te pāmahana nui rima nekehanga.

tukua te medicament e i roto i pharmacies i te whakahaunga anake. Ko tōna ora papa ko rua tau.

Utu me analogues

whakaaro te utu o te tarukino te 120-150 moni i roto i te 5 ml. Ki te tika e taea te whakakapi i te reira e taua tikanga rite "Doxorubicin-Teva", "Lachema Doxorubicin", "Onkodoks 50", "10 Onkodoks", "Doxorubicin-Ebewe", "CRC-Doxorubicin" me etahi atu.

arotake kiritaki o te rongoā

Na e matau ana koutou ki te whakamahi i te tarukino "Doxorubicin". Tohutohu mō te whakamahi, me te rokiroki o te tarukino i te aroaro i runga ake.

he maha nui rawa o arotake kiritaki e pā ana ki tauhohe kino nui e puta i roto i te maimoatanga ki te tarukino. Ki enei pānga he whai wāhitanga okana ā, roa-tonu ongo'i mate, mate huruhuru me te hanganga o tuwhenua i te pae i werohia.

I runga i te karere pai e tino onge ratou. A ko kore poitirere tenei, mai kia arotake te whai huatanga o te anticancer tarukino anake te mātanga mātanga, e hāngai ana i runga i te maha nui o ngā āhuatanga rerekē: te momo o te monotherapy ranei huinga therapy, he mate pukupuku, huru o te manawanui, me ētahi atu hua wā roa-.