Immunoglobulin E me tona hiranga whaiaroaro

Immunoglobulin E me tona faufaa whaiaroaro - take e rapua e whakaaro. I reira, i reira e rave rahi ngā momo o immunoglobulins (paturopi). He maha ngā momo o paturopi e rerekē i roto i te āhua o te mahi, me te huarahi o te wātea i te mate anti-infective. Paturopi whakapataritari rerenga me te flocculation o te rewa hua kitakita, agglomeration me agglutination antigens corpuscular (spirochetes, huaketo, hātare me huakita). I te vibrios membrane pūtau trypanosomes me spirochetes whakaritea immunoglobulins complexes motuhake ki ngä, meinga mōtepe adsorption. Tikanga, Kei te puritia enei māngai hopuhopu i roto i te kiko lymphoid. Ko te immunoglobulins o ngā akomanga G ko M tahi ki ngä e taea hydrolyze spirochetes, trypanosomes, huakita me te huaketo.

e iri Pānga o paturopi i runga i te tukumate te ka tomo te reira i te pūtau, a kihai te faaite i te antigen i runga i te mata pūtau. Ka taea e Immunoglobulins whakakaha haaparuparu i te ātete ārai o te rauropi ranei. matatini antigen-antibody e kei te taikaha antigen, mahi he pānga whakaongaonga, me te matatini ki te taikaha o paturopi ai te pānga ritenga. Nuinga o ngā wā, ko nga immunoglobulins te take o pōauautanga autoimmune me mate pāwera.

synthesized IgE te nuinga i roto i te pūtau o te kiriuhi mucous o te romahā, wahi Gastro-intestinal, me te i roto i taikiri rohe. Hoki te wa tuatahi, rite tāutuhia he piha motuhake o te immunoglobulin E i roto i te tau 1966, a i roto i 1968, e mōhiotia ana te WHO kua rite piha IgE motuhake o immunoglobulins.

kitea tenei piha o pūmua i roto i te tangata, makimaki, me etahi kararehe taiwhanga. Te nuinga o nga rāpoi immunoglobulin E hono ana ki ngā pūtau rewa kiri me basophils. Mai raro noa nohanga tikanga immunoglobulin E i roto i te serum toto o te torutoru nanograms ia ritamano, whiwhi te whakaaro taketake o te hanganga o tenei muingota te anake i runga i te pūtake o te ako o te maha pūmua myeloid. taumata Tino iti o immunoglobulin E i roto i te serum mārama whakatika i te meka e ko te reira e nehenehe o "ngā" ki te mata o te pūtau, me te mau herea ki ngā pūtau rewa me basophils.

Kei te whakapono te reira e Іg E ko te piha nui o immunoglobulins e hua pūtau rewa me basophils ki whai wāhi i roto i mate pāwera. Ko te taumata o tenei pūmua i serum o te nuinga o nui tūroro ki piki mate pāwera, me te 350-800 U / mg. Tapeke tona täkupu e IgE i tamariki i raro i te tau o te 12 marama ki runga ki te 15 U / ml. IgE whai wāhi nui i roto i te tauhohe o te hypersensitivity tonu. Immunoglobulin E täkupu i roto i ngā pakeke ngā i 0 ki te 120 U / ml.

E ai ki ngā ariā hou, te mahi matua o te immunoglobulin E ko ki te tiaki i kiriuhi mucous o te tinana e tika ana ki te faaitoitoraa o ngā āhuatanga rohe o toto wē me ngā pūtau effector. E taea e ki te wahi i roto i te rārangi tiaki e kėia immunoglobulins o te piha haapiiraa A. muri e huaketo ranei huakita i runga i te mata o ngā pūtau rewa herea ki motuhake piha immunoglobulin E, rite ki te hua o taua pūtau pāhekoheko rewa riro te tohu ki te tuku o amines vasoactive me ngā āhuatanga chemotactic, tukumate nei i roto i take tahuri whiwhinga o komuhumuhu iG piha te G, ngä, eosinophils me neutrophils. tauwehe chemotactic Eosinophilic, tukua nei te i pūtau rewa, whakatairanga te haaputuputuraa o eosinophils me te whakangaromanga o kutukutu. Kei te whakapono te reira e adsorbed te IgE i te mata o te werau, rata ana macrophages whakawhetai ki FB-receptors.