Gonadotropin-tuku taiki (GnRH): rawa taero me analogs

Gonadotropin-tuku taiki mohiotia (GnRH) te rite te taiaki e tuku taiki luteinizing (LHRH) me lyuliberin i te mea he taiaki peptide arataukai kawenga mō te tuku o FSH (ruahuru taiki whakaongaonga), me (LH), luteinizing taiaki i te rapae o mārōrō,. GnRH - he taiaki synthesized ka tukua i roto i te hypothalamus o neurons GnRH. no tenei peptide ki te whānau o gonadotropin-tuku taiaki, me te māngai pūnaha taahiraa hypothalamic-rapae o-adrenal osinachalny. Ka tenei pepa e aroaro rite te raveraa ra o taiaki gonadotropin-tuku.

hanganga

Nobel laureates, Andrew V. Schally me Rozhe Giymen faataa i roto i te 1977 tautuhi āhuatanga GnRH: piroGlyu-Giese-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. He aha te mea noa i roto i te whakaaturanga o peptides, te raupapa i homai i N-terminus ki C-terminus mo peptide whakaaturanga, rite mua, engari ano hoki i te paerewa tīpoka chirality ti'araa, whakaaro e waikawa amino i te L-āhua e tū. Ko te whakapotonga runga ake e paerewa waikawa amino proteinogenic. He okotahi Ko piroGlyu - waikawa pyroglutamic, he pärönaki o waikawa glutamic. I te C-terminus tohu NH2 e mutu te mekameka karboksidaminom hei utu o carboxylate free.

kōtuitanga

Ko te kawainga o te GNRH1 ira taiaki gonadotropin-tuku kei roto i te pūira 8 synthesized 8. Normal decapeptide kararehe 92 waikawa amino mua prohormone-i roto i te hypothalamus preoptic mua. Ko te ūnga mo rerekē tikanga pūnaha ture tuaka hypothalamic-rapae o-adrenal leva e whakanui ake taumata o estrogen i roto i te tinana.

taumahinga

Gonadotropin-tuku taiki e huna ana ki roto ki te rere toto o te tomokanga rua rapae o rohe o te hiranga ake waenga. Kei te whakawhiti GnRH ki te repe rere toto o te rua tomokanga kei roto pūtau gonadotropic, te wahi o ratou ake receptors whakahohetia receptors GnRH o te taiaki transmembrane 7 receptor gonadotropin-tuku e pā ana ki G-pūmua, me te whakaongaonga i te beta-isoform o phosphoinositide phospholipase C, e haere ki te roopu o te pūmua kinase C me te konupūmā . Nā tēnei, i roto i te faaitoitoraa o te pūmua e kua whai wāhi i roto i te secretion me ariā o te FSH gonadotropins me LH. I roto i proteolysis wahia GnRH mo te meneti torutoru. Ka rite ki te tamaiti, he tino iti tona mahi, te whakanui ake i roto i te taiohi te taiohitanga ranei. Tei Success i runga i te mahi mahi pulsatility uri te arohaehae te mana e te koropiko urupare. Otiia kahore e mahi GnRH i roto i te hapū e hiahiatia ana. Mate ranei pōrearea, me te organic kino me te momo whara hypothalamus me pukupuku rapae o kia meinga mahi pulsatility koretake te. taumata prolactin piki heke te mahi o GnRH, hyperinsulinemia me te putanga mai te reira, a ai he ngangau o te mahi o FSH ko LH, pērā i roto i ovaries polycystic. āhuatanga Kallmana syndrome e te ngaro o GnRH kōtuitanga.

neurohormones

Ka taea te pēnei GnRH ki te neurohormones. Hua taiaki gonadotropin-tuku i roto i te rohe preoptic ngā nuinga o nga neurons GnRH-secreting. Enei neurons mai i roto i te kopa nasal ka heke ki te roro i reira i roto i te pakitara wehewehe medial me ka marara i roto i te hypothalamus hono ki dendrites roa, neke atu i te 1 mm te roa. Te tukutahi tukua e ratou GnRH ki paihere pūhui āwhina ki te whakaputa i te kōkuhunga synaptic kotahi. Mā te whakamahi i te maha o foaki rerekē pērā i a Kapa, glutamate me norepinephrine whakaritea GnRH secreting neurons. Narpimer, i muri i whakahaere o wahine progesterone-estrogen whakaongaonga dopamine te tuku o te LH; a taea wahine ovariectomized dopamine tautāwhi i te tuku o LH. kia hoki kia whakaritea te regulator tino nui o te tuku o GnRH Kiss-peptin i estrogen. Heoi, i reira ko te oraraa o neuronal secreting Kiss-peptin me te faaite i te Arepa me te estrogen receptors.

He mea nui ki te mohio he aha he agonists o taiaki gonadotropin-tuku. Ka waiho tēnei tuhinga te mōhiohio e pā ana ki reira.

Pānga i runga i ētahi atu whēkau

Ko te tūranga o GnRH painga ako i roto i te tukanga o te ora i roto i te tua ki te repe me te hypothalamus. He ko he pea e te mea he pānga i runga i nga repe takoto me te ewe hoki receptors GnRH me GnRH kua iho kitea i roto i ngā pūtau mate pukupuku, ovarian, endometrial, repeure, me uma.

Pānga i runga i whanonga

Kei te pāngia hoki te whanonga o te hanga o te ira GnRH. Ko te hapu o te ika cichlid ika e whakaatu ana mana pāpori, he a'usia whakarei ture o GnRH secretion, ina whai cichlids hapori tairongo te ture iti o GnRH secretion. Te rahi o te neurons e te huna hoki GnRH ti'aturi i runga i te whanonga, me te taiao pāpori. E tane atu motuhake rahi nui secreting GnRH neurons ches tane iti taratahi. whai hoki hua wahine i te nui iti o neurons atu i roto i te uwha rōpū mana. korero te reira o te ture pāpori o GnRH taiki.

E kōrero Agonists o taiaki gonadotropin-tuku i raro.

tono Medical

Hoki te maimoatanga o te iwi mate i mua i te whakaritea GnRH tūturu rite gonadorelin hydrochloride (Faktrel) me gonadorelin diatsetattetragidrata (Tsistorelin). Kua arahina hanganga whakarereke GnRH dekapiptida ki te hanganga o ahurei, whakaongaonga pehi gonadotropins ki roa hawhe-te ora ranei. Na ka whakakapi i enei analogs waihanga o te ira tūturu. Leuprorelin tairitenga whakamahia mō te maimoatanga o te endometriosis, kartsiomy uma, repeure kartsiomy me muri hoki etahi tau o te rangahau i roto i 1980, i roto i te Vol. H. Komita whakahaere e Dr. Florence i University Yale, mo te maimoatanga o te pūhuruhurutanga o precocious, rite te whaowhia tonu.

Gonadotropin-tuku taiaki: te utu

Ko te utu toharite o tetahi pounamu - i 300 moni.

Whanonga Fakasekisualé Animal

Kei te hoki i meinga e te mahi whanonga fakasekisualé o GnRH rerekētanga. Hei tauira, whakaaturanga whakarei wahine whanonga fakasekisualé ai he hua i roto i te taumata o GnRH. I roto i te pihoihoi ma-karaunatia nui haere tono moenga i muri i whakataki o GnRH, ka whakarei i roto i kararehe whakaaturanga whanonga fakasekisualé i roto i uwha, e taea te kite i runga i te roa-tailed te Shrew ma-whai niho, me ona wā moe o heke i roto i te whakaaturanga te hoki o te tane me te nekehanga i roto i tona ahunga o te hiku. whakarei ake te reira i te mahi o tane testosterone nui haere e GnRH runga ake te taumata noa o te mahi testosterone. mahi ino GnRH ai te whaiaroaro pānga whakakonekone o uri, me te whanonga whaea. Ki te whakarite tatou i te kiore wahine i roto i te pūnaha noa o GnRH, he āwangawanga atu e pā ana ki uri atu i ki te maha heke o neurons i 30% i te wahine. Te nuinga pea, ka waiho enei kiore kuri motuhake, hua i roto i te roa e kitea ratou.

tono kararehe

Hea e hāngai ana taiaki gonadotropin-tuku? Drugs whakamahia i roto i te rongoā kararehe rite te rongoa mo te maimoatanga o te mate ovarian whēwhē i roto i nga kararehe. ona te orotahi waihanga, deslorelin whakamahia hoki te mana kararehe o ngā mahi whakaputa uri te whakamahi i te rawatia ētehi me te waihanga tuku toitü.

A feruri i analogues o taiaki gonadotropin-tuku.

Agonists me te raveraa ra o te taiaki gonadotropin-tuku

Wehe, tika e taea te huaina i te rōpū o te raau taero e pānga tikanga he agonist o taiaki gonadotropin-tuku. Tenei te tikanga e te pānga o tenei rōpū o raau taero i runga i te repe ai te pānga ōrite ki te pānga o ona ake taiki. Ka taea te huaina Māngai o tenei rōpū "Sinarel", "Lyukrin Gonapeptil taupuni." Tenei agonist o taiaki gonadotropin-tuku. E tono ana te formulations i mua, me te i muri i te maimoatanga o fibroids, endometriosis me i mua i te tango i hāparapara te kōpū (hysterectomy) i roto i te maimoatanga o te pākoko. matū kaha i raro i te mana o te break wai pekitīlia me reira e patia taero katoa i raro i te kiri ranei ki te interanazolno uaua.

E te te raveraa ra taiaki gonadotropin-tuku e "Tsetrotid" ( "Tsetroteriks"), "ganirelix" me pera atu.