"Capecitabine": tohutohu mō te whakamahi, ritenga tūturu, puka tuku, te kaiwhakanao. "Capecitabine-TL": tauākī

Capecitabine (. Latin Capecitabinum) - he taonga e ko te pārōnaki carbamate fluoropyrimidine. No te reira ki te rōpū o antimetabolites - pūhui motuhake taea ki te tautāwhi i te tipu o te pukupuku mārere. Ko te moni i roto i te taua matū ahu i roto i 1960 g. I whiwhi hua pai tuatahi e rangahau i roto i kiore. Etahi wa i muri mai, i kitea ai ona whai huatanga i roto i te maimoatanga o etahi mate pukupuku i roto i te tangata.

I teie mahana, e rave rahi taero anticancer kei roto i te taonga capecitabine kaha. Reviews o tūroro maha mea e pā ana ki te angitu o te tono o taua taputapu i roto i te anticancer therapy.

Haumanu me ngā āhuatanga

capecitabine Tātai - 5'-deoxy-5-fluoro-N - [(pentyloxy) carbonyl] cytidine. kanohi rōpū matū Antimetabolites e te maha o ngā matū e he rite i roto i te āhua ki te hua o te pākia e (pākia) tangata. E taea e ki te whai wāhi i roto i tauhohe pūkoro, ka whakarite ia ratou ki te pōturi iho etahi o nga tukanga matüora ratou. Ko te kupu i reira ko te arā i roto i ngā pūtau puku faufaa me inhibition o ratou tupu, ka whakamahi i taka e hāngai ana taonga capecitabine. Kei te korero Reviews o iwi e pā ana ki te whakaiti i te rahi o te pukupuku. ka karanga tenei tikanga o te mahi te cytostatic.

Enei āhuatanga tukua te whakamahi o ngā matū antimetabolitnyh ratou i roto i te anticancer therapy. ratou miramira kï ki te pukupuku mārere o te wahi gastrointestinal me repe mammary. I roto i tenei take, he hua pai homai e rua te monotherapy me te huinga ki ētahi atu āpiha. Ki te rā, i runga i te pūtake o anti-metabolites hanga neke atu i te 800 ngā hua, engari tonu tonu ki te rapu hoki ngā rōpū hou o pūhui.

tikanga o te mahi

Puta Capecitabine Whakahohe i te kopa o te puku, i muri nei tīmata reira ki te faaitoito tona pānga paitini i runga i te pūtau (tikanga cytotoxic). whai wāhi ana tēnei taonga i roto i te pākia e o te tauhohenga me arata'i ki te meka e te hauora me te pūtau puku e tahuri ki analogs cytotoxic. Ko te kupu i reira ko te whakaputa taonga takahi tika mō te DNA kōtuitanga me, no reira, te tukanga wehenga.

Mai te pūtau mutu ki te whakapiki ake i ō rātou tau. I roto i te tahi atu tauari, i reira te mea he "whakauru" o tetahi ki tetahi taonga, ai he pororaru te ariā pūmua ka tango taero e hāngai ana capecitabine pūhui. whakaahua ana Guide i roto i te taipitopito tenei tukanga.

Ko te tikanga o tenei hurihanga whakaiti te taea o te kino ki ngā pūtau hauora. Ko atu takiwa, i roto i te puku ano Capecitabine, atu i roto i nga kopa e karapoti ana. Ko iti kino ki te tinana, he āhuatanga taua ka te te tukinotia tetahi tangata mo te raau e hāngai ana i runga i te taonga capecitabine. Tohutohu mō te whakamahi taunaki te whiwhi moni i roto i te pota tino tautuhi e kua whakaritea e te rata haere.

E noho rawa i roto i te tinana

Ki runga ki te fariiraa i capecitabine ko tona absorption tere i roto i te wahi gastrointestinal. Ki te kai koe i tenei wa, ka pōturi iho te tukanga. Na reira, kawea i runga i te raau taero antimetabolite fariiraa i roto i muri i ingestion. puta huringa atu i roto i te taonga ate, he nui etahi o te capecitabine me herea ona metabolites ki pūmua (hei tauira, albumin). Ko te taumata tihi serum i uru i muri i 1.5 -3 haora i muri i te tono tarukino. korero tenei ki te tarukino "Capecitabine" ako. Analogs i rite pharmacokinetics.

excreted te nuinga o te taonga i roto i te mimi, raro - ki te feces. Ano, rau kore anake te capecitabine tinana tonu (e pā ana ki 3%), engari ona pärönaki. E metabolized etahi o ratou ki pūhui iti kaha. E kore e te noho, me te huringa o te capecitabine i roto i te tinana pāngia e te ira tangata, tau, iwi.

A, no te whakahaere?

Capecitabine ki ngā formulations whakahaere ki te tūroro ki te mate pukupuku uma, tae atu atamira metastatic. I roto i tenei take, te rauemi e whakamahia ana i roto i te anga anake, ngā maimoatanga ki contraindications kore o miramira o te hahau ranei ranei. Nuinga o ngā wā, ngā capecitabine ki docetaxel.

Kei te whakaritea te reira i hoki ki te tūroro ki te mate pukupuku o te kopirua, pū kai, puku, taiaki, mate pukupuku colorectal, e rua i roto i te horapa rohe o te atamira, me te wā metastasis. I roto i te maimoatanga o te mate pukupuku kopirua te tautapatia hoki "capecitabine". Tohutohu mō te whakamahi āta whai i te inenga tūtohutia, ka piri ki te tohutohu o te rata haere.

Ngā pāhekoheko ki ētahi atu taero

Ki te mohiotia koretake hahau, kia whakahau i te mātanga matepukupuku he maimoatanga ngā, ka e kia whakamahia "capecitabine". Tohutohu mō te whakamahi whakarato he rārangi o ngā rauemi, i te mea ka taea ki te uru pai.

Hei tauira, me "docetaxel" - tarukino cytotoxic momo mahi he takenga huawhenua. He mea e taea ki te tohe mo te wa roa i roto i te pūtau i roto i te nohanga tiketike. Heoi, contraindicated te huinga taua o āpiha te mo te iwi ki te maha o platelets me neutrophils 100,000 / ul me 1500 / l, aua. Hoki "Docetaxel" e kore e tono ki tūroro ki te nui haere auau o bilirubin. I roto i tenei take, te taea hopearaa kino. Ki te "Docetaxel" mo etahi take "hinga" o te talena maimoatanga, tonu therapy "capecitabine", engari i pota iti.

I roto i te kaupapa o tauhohe hypersensitivity maimoatanga "capecitabine" me "docetaxel" mutu, me te whakakore i nga tohu i meinga. supplementation Aronui ngā whakawhanake kaimahi matepukupuku rānei mohio. whakaritea ana tēnei kaupapa i roto i te hui o ngā pānga paitini.

e kore te "Capecitabine" whakaritea i te wa ano "Sorivudinom" - he kaihoko patu huaketo. kia whakanui i tenei huinga o te tāoke o te tarukino tuatahi. Ko te whakamahi ngā o antiepileptic tarukino "phenytoin" faarahi te kukū o te muri i roto i te wē toto. Ko reira ano hoki e taea te whakararuraru, toto i roto i te whakamahi o anticoagulants coumarin me tikanga, te wahi i te wāhanga matua - capecitabine. Tohutohu mō te whakamahi whakatupato o nga mau hopearaa taea, na me te tuatahi waia koe koe ki reira.

Ko wai te contraindicated?

Ko te take contraindicated e te ranei e iti ki te tarukino kia:

• tūtohutanga High (hypersensitivity tauhohenga).
• Ko te aroaro o nui iti hoki tākihi ate ranei.
• wāhanga Various o hapūtanga (pānga te hua te tarukino), me te haunga o te wā i reira hoatu ora o te whaea i roto i matua;
• Feeding kai hou.

te whiwhi hoki rohe capecitabine mō te iwi ki te mate ngakau coronary (CHD), ka he āhua o nui haere kukū o bilirubin i te toto, te mate ate metastatic ki te tūkino o ona mahi taketake. Kei te tūtohutia kahore faaineineraa mō ngā rangatahi i me te kaumātua. haapapu tenei te tarukino "Capecitabine" ako. Mua korero e pā ana ki te whānuitanga o ngā pānga taha me ngā pānga paitini i roto i te maimoatanga. Na reira, e capecitabine therapy wahi i raro i te te tirotiro tino o te matepukupuku rānei mātanga.

He reira tetahi pānga taha?

I muri tango i te raau taero e taea e te ānini, āhua o rohirohi, lethargy, ngoikore. kia ohoroa puta, ranei hurihia - momoe. I roto i te wā onge - mate o te ruruku me te pauna, whakama.

pānga te taha i runga i te pūnaha Cardiovascular he anemia (anemia). Ki te whānuitanga iti kia meinga ai angina, ischemia myocardial, patunga, kore ngakau me ētahi atu. Ki te whai wāhi te tukanga o te whekau romahā, i reira kia kia hāhā o te manawa, nui korokoro, mare. Tino uaua - Embolism pūkahukahu, mamae tana pukapuka.

A, no te whakamahia i roto i te hanganga anake ngā pānga kino taea maimoatanga i runga i te pūnaha musculoskeletal ranei. faaite te reira ano i roto i te mamae i roto i te wahi me te hope, whakatika uaua hypertonus (myalgia), mamae tahi (arthralgia).

kia hoki kia pāngia te kiri. Kia meinga dermatitis, erythema, maroke nui o te kiri, whero, mania, te kōpā, tihorenga, minamina, nui haere ähua, kino pānga whao. I roto i te wā onge reira he kapiti kiri, hypersensitivity ki iraruke hihi-katikati, tihorenga ka nui haere fragility o paraharaha whao.

I roto i te tahi atu ngā kino kia puta tukanga hopuhopu tika ki raro parepare o te tinana. I muri therapy tarukino ai te hekenga i roto i platelets toto, me te ma ngā pūtau toto. faaiteraa taua whakaahua ana te medicament "Capecitabine" ā-ako. Analogues hoatu te taua pānga.

te raau taero

"Capecitabine" tika anake hoki te whakamahi ā-. Ko te tikanga te horoinga ki raro, ki te wai i muri i te hawhe haora i muri i te kai, otiia e kore e muri. whakaritea te horopeta ia rā e te matepukupuku rānei te haere, i runga i te rahi o te pukupuku, te wāhanga whanaketanga, me te tapeke rohe mata tinana rānei. Ko reira e minaminatia e kua i te mātanga te pūkenga ki te mahi ki tenei tarukino. Ko te tino pinepine whakaritea rua-rā - te ata me te ahiahi. I roto i tenei take, pumau te akoranga katoa e rua wiki, a ka - te whati mo te whitu nga ra, aru e te maimoatanga tukurua.

Hoki tūroro ki iti hoki tākihi, heke te pota rā. Na roto i te whakaiti i te maha o leukocytes (leucopenia) me neutrophils (neutropenia) i roto i te toto tonu tango i te raau taero. Na taunaki te tikanga o "Capecitabine" ā-ako. Taurite analogues ranei whakahaere i te kaupapa o te rata haere.

tāoke

He maha ngā nekehanga, kia rite ki nei whakawhanake pānga paitini o te tarukino "capecitabine" (tohutohu mō te Whakamahi). Reviews o iwi maha mea e ko he tukanga takitahi tenei.

He maha ngā nekehanga o te tāoke:

• 1 tohu. He torutoru ngā pānga taha.
• 2 tohu. Ko te korere kaha (ki runga, ki te 4 wā i te ra) aru e alangá ngawhatanga, whero, whakararuraru mahi, he hua koi i roto i te bilirubin. I tenei wā, te fariiraa aruaru capecitabine noa tohu o te tāoke o atamira 1.
• 3 tohu. Korere whakaora ake ki te 9 ngā wā ia ra. puta te reira i malabsorption (sprue). A, no te i kitea tenei i te kiri kaha tihorenga, whero, opupu me mariao. He koi mamae i roto i te topito, heke haere mahi. nui haere Bilirubin e 3 ngā wā. I tenei wā o te maimoatanga e mutu, me te fariiraa i te tikanga i roto i te horopeta raro tonu i te faaiteraa o te tāoke o te 1 tohu.
• 4 tohu. korere atu auau - ki runga ki te 10 ngā wā ia ra. Kumete ki te toto. He he he hiahia mo te whakataki o te raau taero, bypassing te wahi gastrointestinal. Ki te kia mutu, me te kore tohu o tenei tohu o maimoatanga anō.

He aha mehua Me ki mau haumaru?

kia tango i te akoranga o te maimoatanga wahi i raro tata te tirotiro hauora. Me te mātanga wā kitea faaiteraa paitini -. Ahakoa whakapairuaki, korere, me ētahi atu i runga i te rapunga o enei āhuatanga, whakaritea te maimoatanga te. Ki te tika, faaore tohu, whakaiti i te horopeta rā, kia he whati. kia haere tonu Treatment, ki te kahore e tū tohu o te tāoke te riri ki te ora.

Hoki te iwi ki coronary mate ngakau tirotiro mātanga kia rawa tino. I roto i tenei take, e hiahia ana koe wa ki te whakakitea te pā tōraro i runga i te pūnaha Cardiovascular me i roto i te wa ki te hanga i nga whakaritenga e tika ana.

Tohunga te whakamanawanui i te whakamahi o te taonga i roto i te mahi pediatric. E kore kua te whai huatanga o tona whakamahi i whakapumautia mō ngā tamariki. Ki te waiho i raro maimoatanga te ki te wahine o te whanautanga tamariki tau, kia tohutohu ia i runga i te pānga o te capecitabine i runga i te kukune. I roto i te akoranga o te therapy, kia whakamahi ia te whakawhānau pono.

Teuteu me analogues

He maha ngā hua i runga i te pūtake o te capecitabine. I roto i te mākete Russian reira e 7 ingoa o te raau taero, whakaputaina e rave rahi kamupene kāinga, me te ke hokohoko. Hei tauira:

• "Capecitabine".
• "Capecitabine-TL".
• "Tutabin".
• "Xeloda".
• "Kabetsin".
• "Kapetsitover".
• "Kapametin FS".

Mai te turanga enei tikanga katoa kotahi me te whakauru hohe taua o - capecitabine, hoki ka rite te ako ratou. Ko te tikanga tohu te reira i te tepu mo te tātai i te inenga homai taimaha tinana me te ako mania maimoatanga ka he tohu o te taumata o te tāoke.

He mea nui ki te matau e ki kia pānui i te mea tuatahi, i te mea kua whakaritea e ia, hei tauira, "Capecitabine TL" - te ako. Te mōhiohio i roto reira e kore te mea e tika ana mō ngā taputapu whaiaro whakahaere-! tātaitanga katoa e pā ana ki te horopeta me maimoatanga talena, hua he tākuta - matepukupuku rānei ki rawaka mātau i roto i tenei mea. Whaiaro-whakahaere o āpiha anticancer meinga kino tūnguru ki te tinana.

Kia whakaaro tatou etahi o nga taero.

Whakaahuatanga o teuteu

• "Capecitabine - TL" hanga te OOO kamupene Russian "Hangarau o ngā rongoā." He wāhanga matua - capecitabine. Tohutohu mō te whakamahi, te puka tuku o te moni ki tokomaha. A feruri i te kōrero. Tenei papa, pani kiriata-. Ko te ihirangi o te taonga hohe - 150 500 ranei mg. wāhanga Ngaahi Houalotú: cellulose, reihuka, te konutai croscarmellose, hypromellose, konupora stearate. kia kotahi mōkihi 60 ranei 120 papa, i runga i te inenga o te tarukino rānei "Capecitabine - TL". Me whai tohutohu ngā mōhiohio āmiki e pā ana ki te whakamahi o moni.
• "Capecitabine" - hua kāinga ki te whakauru hohe taua. Ko rite ki te tikanga i tabulahia i runga ake i tona whakaahuatanga. puka Tuku o te tarukino "Capecitabine" - papa. E kopakia ana hoki tohutohu mō te whakamahi i roto i te mōkihi.
• "Kabetsin" - māngai anticancer o te hanga Russian ( "Kamupene" Deco "). Hua puka - papa kiriata pani ki 150 500 ranei mg o taonga kaha. kai Tuarua: microcrystalline cellulose, crospovidone, māngaro, konupora stearate. Waiho i pharmacies anake i te whakahaunga.
• "Kapetsitover" - he hua o te kamupene Russian OJSC "Veropharm". Tēnei māngai anticancer wātea i roto i nga papa o 150 500 ranei mg o 60 - 120 nga wahi. Haunga capecitabine, i roto i te faaineineraa ngā reihuka, cellulose, te konutai croscarmellose, te konutai stearate, me hypromellose.
• "Kapametin FS" - whakaputaina e te kamupene Russian "Weringitana" - he wāhi mātātoa i roto i te hōtaka o te kawemai whakauru o taero. "Kapametin FS" tukua te inenga o 150 - 500 mg kaihoko hohe - capecitabine. Tohutohu mō te whakamahi (kaihanga hoki Whakatakotoria i roto reira) e korero ki a koe te tini o papa ia mōkihi - 60 120 ranei.
• "Tutabin" - hua ke i runga i te pūtake o te capecitabine. hua te reira i te kamupene Parata Laboratorio VARIFARMA SA, i te mea ano hoki te kaihoko kairēhita. "Tutabin" hua i roto i te puka o papa ki te ihirangi whakauru hohe o 500 mg. pouaka pepa me te tohutohu tukua - Packaging.
• "Xeloda" - he kaihoko antitumor. I whakaputahia i roto i Switzerland e "e F. Hoffman La Roche" me ona āpiti me tari māngai i roto i ētahi atu whenua - Mexico me te United States. I roto i te mākete Russian reira e 5 taero ki te ingoa hokohoko. puka Hua - papa (150 - 500 mg) i 60 ranei 120 nga wahi. i roto i te mōkihi kotahi.

Reviews

Reviews o te mahi i runga i te pūtake o te momo o drugs capecitabine. He pai te nuinga o ratou, engari i reira e ano arotake kino. Heoi, e kore e tenei tohu enei moni kia rite ki te pai, ahakoa kino, no te mea kia tangohia nga wa katoa e koe ki te pūkete te individuality o te tinana o ia takitahi. Te fariiraa i te taua tikanga o te iwi rerekē e kore e hoatu i te hua taua. O te faufaa nui ko te meka i patua tinana i neoplasm me pehea te roa ka haere i te reira i runga i.

Iwi nei ka mau te tarukino, e ai ta te pānga paitini kaha i muri i te maha ra o te whakauru. Heoi, tokomaha pūrongo whakapai ake nui i roto i to ratou huru, a tae noa te urunga ki te murunga. He huru nui e ka mahi me te taea te tarukino mo te tangata kotahi, he matepukupuku rānei haapa'o me pipiki tino ki ana tohutohu e pā ana ki maimoatanga.