Bisphosphonates (taero): whakaahuatanga, ngā tohutohu, arotake. Bisphosphonates i roto i te maimoatanga o te osteoporosis

A, no te riro pakarukaru me pakarukaru wheua tangata, a ka tupu te reira i roto i te tahi mau mate o te wheua, kei te tino heke te kounga o te ora. piere toutou, mamae i roto i te hononga, tuarā me wahi timata ki te tahi tangata i nga wahi katoa, i te mea he aha e taea e koe tino mutu ongo'i te hari o te ora, me te rumakina e ki te hepohepo.

Ko ko to tatou oaoa ki a koutou i roto i te ao i teie mahana e drugs motuhake e taea tōtika whakakaha wheua kiko. Ko reira e pā ana ki a ratou, a ka e lāulea ki i roto i to tatou tuhinga. I huaina enei raau taero "bisphosphonates" - raau taero e arotake e taea te hoatu te tumanako o te rongoa mo nga iwi maha hepohepo. Whakapono ahau, he rota taua! Ka korero ki a koutou tatou e pā ana ki te hītori o enei moni, e pā ana ki te mea e ratou pera pai, he aha te mea te pūtake o ratou painga hauora, ka whakaputa ko nga tino rongonui, me te whai hua nga ingoa o nga bisphosphonates.

ka kia whai hua mō te katoa te tuhinga. I muri i te katoa, ara, ki te he i tenei ra i nga mea katoa i roto i te tikanga, ka, kāore, e kore e auraa hauora koe me a koutou potiki aroha, ka muri reira ake ake. haere i nga tau, ki te tua o to ratou mate kei te hoko atu me te ake. Heoi e kore e waiho te aha e pā ana ki ngā rongoā hou hira. Ko nui o Taenga mai o te! Kia tahuri tatou ki te ako atu nui o te kaupapa o tenei tuhinga.

Bisphosphonates - raau taero mō te wheua hauora

rōpū whiriwhiri o taero waihanga e whai i te kaha ki te aukati mahi o osteoclasts (pūtau e whakangaro wheua kiko) o te tinana, me te whakahoki mohiotia te hanganga wheua te rite bisphosphonates.

Ko tēnei wā e whakamahia ana enei taero i roto i te wahi tuatahi mo te tiaki o te tūroro ki te osteoporosis me ētahi atu mate e meinga wheua he pakarukaru. Ko hoki te taonga tino faufaa o bisphosphonates te meka e kia kia whakamahia ratou i roto i nga mate oncological āhuatanga e te hanganga o te pukupuku i roto i te wheua. I roto i enei take, i te raau taero, e parau to matou tuhinga, e kore e hoatu e metastases horahia, ka whakaiti mamae i roto i enei tūroro.

Ko te tikanga o te mahi o bisphosphonates i te maimoatanga o te osteoporosis

I roto i te pene o mua, ua haapii mai koutou e bisphosphonates - taero e whakatairanga wheua tōtika. Ko te wa ki te kōrero atu e pā ana ki te huarahi o to ratou mahi. pūtau o to tatou tinana i te kaha faahiahia i wa wa ki kia whakahoutia, ka whakahou. Wheua kikokiko - he kahore okotahi. Taurite kua tonu ratou hanganga, i runga i te ringa kotahi, nga pūtau osteoblast e he kawenga mō te hanganga o te kiko hou, te tahi atu - osteoclasts e he kawenga mō tona whakangaromanga. BF i te mana ki te pōturi iho te mahi o osteoclasts me tae noa rere ratou tikanga whaiaro destruct-. I tenei taonga faahiahia me hāngai maimoatanga bisphosphonate o osteoporosis.

Me mea e ahau e kore i mohio ki te tino kaiputaiao kia tawhiti te huarahi ārai o te wheua mate te whakamahi i bisphosphonates. Kei te mohiotia te reira e enei matū e taea ki te here ki te wāhanga wheua hydroxyapatite, taea ai ratou te huri tona tauhia me i te wa ano whakaiti i te kukū toto o hydroxyproline me phosphatases.

I te tahi taime e ai whakahaere teuteu BF i roto i te maimoatanga noa o mate pērā i herniation protrusion o kōpae intervertebral ranei, rite āpiha analgesic. Na he iti ētahi atu pārongo: bisphosphonates hoki osteoporosis kua whakamahia hoki te wa roa, engari mo te mate pukupuku, kua whakamahia ratou tata. Na roto i te akoranga i kitea ai e tomo i te tinana, te wahi te kaha e wātea ana i roto i te tukanga neoplastic, e kore e hoatu bisphosphonates te puku coalesce ngā pūtau ki te kopu wheua, me te reira tautāwhi i hanganga o metastases. Ka taipitopito atu anō e pā ana ki tenei e kōrero i roto i te pene motuhake.

He hītori iti

Huri i te reira i roto i taua i kitea bisphosphonates e pūtaiao mō te wa roa, ara i roto i te rau tau XIX. Hoki te wā tuatahi kawea te ariā o te BF tuatahi i roto i roto i Germany. Ko reira maere e enei matū e whakamahia ana te tuatahi anake i roto i ngā rāngai ahumahi (mo te hanga o maniua, te hanga o papanga, hinu para me te rite. D.) A auauhia ki rongoā kihai i.

Hoki ngā take hauora - mo te maimoatanga o te wheua - timata bisphosphonates ki te whakamahi anake i roto i te rau tau waenganui-rua tekau, i te mea kua kitea reira ratou taonga mīharo ki te whakaawe tukanga pērā i calcification me decalcification. He mātātoa rawa Bisphosphonates mō te osteoporosis whakamahia mai huri noa i te ao.

whakarōpū o bisphosphonates

I teie mahana, whakawhanakehia Pūtaiao te toru o whakatupuranga biosfosfonatov. Otiia e kore e tenei tikanga e kua whakarerea tino kaiwhakaako te whakamahi o te raau taero o te whakatupuranga tuatahi, me te tuarua, i whakaaro nui mua. Matara i reira! I teie mahana i reira e maha raau taero e kua hāngai i runga i bisphosphonates. Kei te wehea tenei momo katoa o ngā rongoā ki e rua ngā rōpū: bezazotovye ngā rongoā me te hauota. Ratou pānga i runga i te pūtau osteoclast he huarahi rerekē. Kei raro e titiro tatou ki ngā rōpū e rua i roto i te taipitopito atu.

bisphosphonates hauota-kei roto

Tenei rōpū o taero ko nga bisphosphonates, kei roto i te kai kaha e whai ake nei:

• waikawa Ibandronatovaya. i synthesized E te taonga tata, pera ko te tarukino o te toru o nga whakatupuranga. Kei te whakamahia te reira i tino pai i roto i te maimoatanga me te ārai o te osteoporosis i roto i nga wahine nei, kua tomo ki te wā uaua o te menopause. e kore te tangata tango i tēnei tarukino tūtohu. Kei te whakamahia hoki waikawa Ibandronatovuyu i hua pathological i roto i te konupūmā toto (hypercalcemia).
• waikawa Zolendronovaya. pā ana hoki ki te toru o whakatupuranga bisphosphonate. Taea ki te mahi tīpakongia i runga i te wheua kiko. Ki tenei te tōtika e whakamahia ana mo te maimoatanga o te osteoporosis. hāngai ana te waikawa mahi zolendronovoy whiriwhiri i runga i te hanganga wheua kei i runga i tona ara pakuwha tiketike ki te wini whakakahokaho osseous e whakarato inhibition pai o osteoclasts. Ko tētahi atu taonga nui o te tarukino - he pānga anti-puku korerotia. I runga i te pūtake o te waikawa e wātea ana zolendronovoy rongonui bisphosphonates "Zometa", "Zolendronat".
• konutai Alendronate - he tikanga whakatupuranga tuarua o bisphosphonates. Ko te kaipānuiwhakatika motuhake kiko wheua pūkoro kore-hormonal hanga i te hanganga tika o te wheua. Kei te whakaaturia te reira i hoki te whakamahi i roto i te osteoporosis e rua wahine me te tangata.
• konutai Ibandronate ( "Bonviva" "Bondronat" "Boniva" - bisphosphonates taka i runga i tona pūtake) - toru o whakatupuranga taero. Inhibits mahi osteoclast i waho e pā i te maha o ratou. e kore e paa kino te reira i te hanganga o ngā pūtau wheua, te kupu tōtika whakaiti ratou whakangaromanga. tokoni pai i roto i nga wahine postmenopausal rite te māngai ārai o piere wheua.

Teuteu e kore e e roto i hauota

A inaianei ka arotahi tatou i runga i te mea e he bisphosphonates hauota-free. Drugs, e ingoa koutou i kite inaianei, no ki te whakatupuranga tuatahi o bisphosphonates:

• "Clodronate." ārai te reira i osteolysis me hypercalcemia whanaketanga e rua. hanga te reira i te hononga matatini ki te wheua hydroxyapatite taui te wini whakakahokaho karaihe, me te mātātoa counteracts te wehenga o ngā rāpoi ngota konupūmā me te Phosphate. Metastases i roto i te wheua ärai ratou whanaketanga me poraka te hanga o hinonga hou.
• "Konutai Etidronate". Whakatairanga faaho'iraa mai o te mate wheua i roto i te wahine ki te tātaritanga o "osteoporosis". taea hoki te whakamahi i te reira i mate a Paget, hypercalcemia me te rite. D.
• "Tiludronate Konutai". haapuai Mineralizes me wheua kikokiko, piki reira rāpoi pūhui, me te konupūmā Phosphate, inhibits te whakangaromanga o te wheua. Whakaritea ki tūroro ki tātaritanga o "deforming osteodystrophy" ranei "mate o Paget" kia whakaritea hei utu o hormones.

Bisphosphonates - raau taero, te rārangi o e kua whakaputaina matou - hokona anake i runga i whakahaunga, e ko te ki hei matū puai ... Whakamahia ratou i to ratou ngarahu pai taea e mōrearea mō te hauora koutou! Kia mahara ki taua BF - ko kore huaora kinokore tāpiringa ki te konupūmā ranei. E mātātoa ēnei taero wawao i roto i te tukanga e puta ana i roto i te tinana, a ki te hē tono taea te āwhina hei utu o te kino.

ture whakauru

taero bisphosphonates rawa puhoi whenumi e te wahi gastrointestinal, uaua ratou absorption. Na reira, he kaha reira ako whakatakoto inu enei taero anake i runga i te puku kau, e pā ana ki te 30 meneti i mua i te kai - i te reira te tikanga e tauturu te absorption o matū tarukino kaha. Me ki mohio tūroro e tenei rōpū o taero e taea o meinga mumura me te horo i roto i ngā wāhanga rerekē o te wahi gastrointestinal. Hei karo taua pōauautanga, i muri i te fariiraa i papa e tika ana ki te tamata i roto i te haora e kore e haere, a ka noho i roto i te tūranga tika. whiriwhiri te inenga e te rata haere.

Tikanga, te whakarite o bisphosphonates tākuta whakatakoto te manawanui tonu me ingestion o pota nui o te konupūmā. Na, fariiraa tukutahi o rua waho. Teuteu kei roto konupūmā, kia tangohia i muri i tango bisphosphonate muri anake e rua haora, a kahore i mua. Ko tētahi atu kupu nui: CF whai ki te inu kahore tea, te waiu, wai ranei kawhe, me te wai mania (he rota o).

Ko te whakamahi o bisphosphonates i mate neoplastic

Ētahi atu korero e pā ana ki bisphosphonate maimoatanga o mate e pā ana te tupu o te pukupuku o te natura rerekē. Ko te takanga o te metastasis i roto i te wheua kikokiko he taha i te taha ki te pāhekoheko tauutuutu i waenganui i ngā pūtau puku, me te mahi pūkoro o te wheua kiko. I roto i te tahuri, haere tahi te whanaketanga hihiri o metastases e adhesion o ngā pūtau puku ki ngā hanganga wheua, me te whakaekenga, tini, me te neoangiogenesis. Kua whakaaetia maha rangahau preclinical kaipūtaiao ki te hanga i te whakaaro e tautāwhi i BF ia o enei wāhanga o pathogenesis.

I roto i te akoranga o te maha ngā hōtaka rangahau arotakea matou te pānga o te bisphosphonate "Clodronate" i runga i te whanaketanga o metastases i wheua i roto i nga wahine pāngia ki te mate pukupuku uma. i whiwhi hua pai: ko te faaineineraa i āwhina ki te whakaiti i te pā o metastases, me te tupu o te kiko wheua hou i roto i ngā tūroro. I tēnei wā, kei te rangahau i roto i tenei aronga tonu kaha. Bisphosphonates ka metastases wheua e taea ki te āwhina i tino.

puku mārere Kei te maha haere tahi e (tuku konupūmā i te wheua) hypercalcemia. A, no te tupu lesion metastatic o wheua konupūmā mate tere e tika ana ki tona whakangaromanga e osteoclasts. I tua atu, hypercalcemia i mate pukupuku ahei puta tika ki te rongo ki te peptide puku. I tua atu, i reira he faaitoitoraa o osteoclasts, ārahi ki hypercalcemia. He uaua ka whakatere ano i whakaiti i te tenei tukanga mahi tākihi.

e puta ēnei tukanga ki taua malignancies rite mate pukupuku squamous pūtau, myeloma maha, mate pukupuku uma, mate pukupuku pūtau tākihi me etahi lymphomas. Hypercalcemia, whakapataritari i mate pukupuku, te raau taero whai hua tino he bisphosphonates mō te whaowhia rō-uaua. Well whakapumautia i roto i enei take, taua raau taero, bisphosphonates, rite "waikawa Zolendronovaya" me "Pamidronate".

whakaatu kitenga e kua he torutoru ra i muri i tomokanga o te whakahaere ki te tūroro e pâmuhia taero raraunga i roto i te kukū toto konupūmā He māoriori, a ka pumau te pānga mō te wā tino roa o te wā (i tetahi ki te e rua wiki).

Ko te rārangi o mate i roto i nei e whakamahia pai bisphosphonates

• Osteoporosis.
• Myeloma.
• Maumaui o wheua hanganga.
• mate (osteodystrophy deforming) o Paget.
• hyperparathyroidism Paraimere.
• Te pukupuku, me metastases i roto i te wheua, rawa ngā ki hypercalcemia.

pānga taha

Kia aroha mai, e kore e taea e te maimoatanga bisphosphonate kaha kia innocuous. Rawa ka tae mai te reira ki te whakahaere rō-uaua o enei taero. Ka taea e ratou meinga te pānga taha kino e whai ake nei:

• A, no te whakahaere pâmuhia, - hypocalcemia.
• Ka taea e pēhia ngā te whatukuhu, meinga haurangi.
• I te tahi taime whakaoho fariiraa Amen biosfosfonatov te whanaketanga o osteonecrosis o te kauae.
• Whai wāhi ki te whanaketanga o keha i roto i te pū kai, me te i roto i te puku.
• Ka taea e meinga kōroke ranei korere, i roto i te wā onge - uaua i roto i te horomia.
• ahuatanga General, ngoikore, whakapairuaki.
• mamae uaua.
• raruraru Vision.
• Rashes i runga i te tinana.

Ae, katoa o enei whakapawera taea meinga bisphosphonates. Drugs, nga ingoa o e whakatau koutou i roto i tenei tuhinga, e kore koutou e taea e whakarite takitahi ahau ki kore meinga pohehe te kino tūnguru tinana. āta faahiti tatou i te reira e rave rahi mau taime i roto i te kuputuhi! Whakawa i nga arotake, e taea te pānui i roto i ngā huinga rerekē, kei te kaha te tiri iwi mōhiohio ki ia atu e pā ana ki ngā BF me tūtohu ngāwari ratou ki etahi atu. Ko te ahua unethical tenei. Tangohia enei taero puai he tika anake i runga i te kupu tohutohu o te tākuta te haere a nga wa katoa i raro i tona mātakitaki.

Bisphosphonates - arotake o kaiwhakaako me tūroro

I mohio koe e nga tau, i runga i Oketopa 20, i roto i nga whenua katoa o te Day Ao o te whawhai ki osteoporosis? Tenei mate i roto i nga tau tata nei, whiwhi i te pono hanganga urutā. Ahakoa e whakapono ana te tahi mau tohunga e te ahua rere te ru o te raruraru o te osteoporosis, no te mea kahore he te mate i roto ano mate. Otiia, ko te tino nui te ōrau o te iwi ruhiruhia e mate i muri i te whati hip, e maha tupu ina te whakatere reira wheua mate. Na reira, He tino tūmanako i runga i bisphosphonates he tokomaha nui o te iwi. Reviews o tūroro e riro enei taero no te mea o te tumanako o te faaoraraa, î ki mauruuru ki te tākuta me te Pūtaiao hou, i i taea ki te whakarato ratou ki te āwhina wā.

Dr. med. , Ahorangi me te upoko o te Center Scientific-Haumanu o osteoporosis Svetlana Rodionova whakapono e te āhuatanga ki te osteoporosis nui nui i roto i Russia. He tākuta pai-mohiotia ta e i roto i to tatou ra, ka he hapa te mana o te nuinga o te iwi (kore o te konupūmā), whiwhi tohatoha papatipu o taua peu kino pērā i te kai paipa, te whakamahi o te raau taero, me te waipiro, me te korikori tinana te tere tata kore, he maha iwi taitamariki, te nuinga wahine e mate ki atu pakeke tau osteoporosis. Na te hiahia mō ngā taero whai hua pai ki te āwhina i te whakaora i tēnei mate, ko te tiketike rawa.

Ko bisphosphonates whakarite o tākuta auau, te ahorangi o te whakaaro e kore e tika ai tonu reira. Bisphosphonates - mahi-te whakarei ake taero, engari te manawanui i mua i tuhituhia i te whakahaunga ngā, me kia tino ki te tango ki te pūkete taua āhuatanga rite pākia o te wheua, me te konupūmā homeostasis te tākuta. A, no te ai meinga te therapy bisphosphonate hikaka, me te tutu pōauautanga nui: fibrillation Atrial, osteonecrosis o te kauae, piere subtrochanteric o te pūkaka.

I runga anō i te whakaaro o te tākuta whai, e kore e bisphosphonates te raau rapaau ao, kia whakatata ratou whakamahi ki te tūpato. Na, päpäho te hōtaka "Hauora" Kei runga i te pouaka whakaata, te wahi Elena Malysheva ki te ataata reka faafariu te whakarongo i reira he mea māmā atu ki te kia tukinotia hoki osteoporosis, he tuatoru-whakatupuranga bisphosphonate. Kaua e whiwhi rawa whakawhirinaki infomercial. Ētahi iwi te whiwhi BF te tino contraindicated. Hei tauira, tūroro ki nui mate tākihi.

Na hoki te arotake i runga i te āhua o ki te mahi bisphosphonates ka metastases wheua. He mārama whakaaro Medical: e tino taea ki te mutu i roto i te tupu wheua o ngā pūtau mārere, e, o te akoranga, tauturu tūroro hinga tetahi o nga mate tino kino, e anake te vai i roto i te ao i teie mau raau taero.

mutunga

Na e matau ana koutou he aha te mea te reira - bisphosphonates. whakaturia Tohutohu mo ratou te whakamahi i roto i konei, me te he rārangi o taero homai ki a tatou e kore e rite ki te kupu, me te he hoki arata'iraa anake - tēnā utu koutou whakarongo motuhake ki tenei! Ki te kore e hiahia raruraru nui ki te whaiaro medicate-ki te hauora te pai, - kite hohoro te tākuta, na ka mau ia ki a koutou ki faaineineraa hauora. hiahia matou a koutou hauora pakari katoa me te oaoa!