Beta-blockers: rārangi taero, tohu hoki te whakamahi

Kei te whānui Drugs ki pānga haumanu nui whakamahia e te tohunga. E whakamahia ratou mo te maimoatanga o mate cardiac, e ko te tino auau i roto i te tahi atu pathologies. He pea atu ki arahi ki te mate o te tūroro enei mate. Medicines e kua hiahiatia ki te hamani enei mate, he beta-blockers. E te aroaro piha Rārangi o taero, arā, o te 4 wāhanga, me o ratou whakarōpū i raro.

Whakarōpū o peta-blockers

Ko te hanganga matū o te piha haapiiraa tarukino kākahu-kore, me te i te pānga haumanu he motuhake. He nui atu nui ki te tohatoha motuhake ki te receptor ngā me te ara pakuwha mo ia. Ko te teitei te pū mo te beta-1 receptors, te pānga taha iti o taero. I roto i tenei whakaaro, ki te rārangi o te raau taero beta-pūārai aroaro rite auhia.

Ko te whakatupuranga tuatahi o ngā hua:

• kore-whiriwhiri beta-receptor 1 me te momo 2, "Propranolol" me "Sotalol", "timolol" me "oxprenolol", "nadolol," "Penbutamol".

Te whakatupuranga tuarua:

• beta whiriwhiri momo receptor 1, "bisoprolol" me "Metoprolol", "acebutolol" me "Atenolol", "Esmolol."

whakatupuranga Tuatoru:

• beta tīpakopako 1 blockers ki atu āhuatanga pharmacological: "Nebivolol" me "Betaksalol", "talinolol" me "celiprolol".
• Nelektivnye beta-1 me te beta-2 blockers ki atu āhuatanga pharmacological: "Carvedilol" me "carteolol," "Labetalol" me "bucindolol".

Enei beta-blockers (kite rārangi o raau taero. Runga ake) i ngā wā rerekē, ko te rōpū matua o taero e kua whakamahia me te whakamahia inaianei mo mate o nga oko toto, me te ngakau. He tokomaha o ratou, te nuinga māngai o te rua, me te tuatoru o nga whakatupuranga, e whakamahia tenei ra. Nā ki o ratou pānga pharmacological whakahaere ki te whakahaere i auau ngakau, me te pupuri ūngeri mōwaho ki te ventricles, ki te whakaiti i te auau o whakaeke angina o angina.

Key ki te whakarōpū

Ko ngā mema o te whakatupuranga tuatahi nga taero tuatahi, e ko, kore-whiriwhiri beta-blockers. homai he rārangi o taero me taka te runga ake. Enei taero ahei o ārai nga receptors o te 1 me te momo 2, whakarato e rua ngā pānga haumanu, me te taha, faaite nei te bronchospasm. No te mea kei te contraindicated ratou i roto i te tūroro ki te COPD, huangō arahau. Ko te nui tino o te raau taero whakatupuranga tuatahi he "Propranolol", "Sotalol", "timolol".

I roto i te māngai o te whakatupuranga tuarua o te rārangi o drugs beta-blockers, te huarahi o te mahi o nei e pā ana te ki te tuatahi ārai i te mau farii ohipa momo tuatahi. E āhuatanga ratou e te ara pakuwha ngoikore mo te momo receptor 2, no te mea meinga uaua bronchospasm i roto i te tūroro ki te huangō me te COPD. Ko nga whakatakataka tino nui o te whakatupuranga 2 e "bisoprolol" me "Metoprolol", "Atenolol".

toru o te whakatupuranga o te peta-blockers

Māngai o te toru o nga whakatupuranga - ko te blockers peta hou. Ko te rārangi o taero ngā "Nebivolol", "carvedilol", "Labetalol", "bucindolol", "celiprolol" me etahi atu (kite. Runga ake). Ko te nui tino i te wāhi haumanu o tirohanga e te whai ake: "Nebivolol" me "Carvedilol". Origin pai io āraia beta-1 receptors me whakaihiihi ana te tuku o KORE. meinga tenei e te roha o oko toto, me te whakaiti i te mōrea o whakatū papa atherosclerotic.

Kei te whakapono te reira i taua beta-blockers - taero mō te takawhita me te mate ngakau, i "Nebivolol" - he tarukino kano e te mea pai hāngai mō ngā take e rua. Heoi, he paku ki runga ake i te utu o nga ētahi atu tona utu. Rite i roto i ngā āhuatanga, engari paku atu te utu, ko reira te "Carvedilol". fakatahai te reira i te āhuatanga o te beta-1 me te Arepa-pūārai e āwhina ki te whakaiti i te auau me te kaha o contractions ngakau, me te ki te whakawhānui i te taha o nga oko.

Ēnei pānga tukua ki a koe te whakahaere ma'i kore ngakau , me te takawhita. A i roto i te take o te kore ngakau, "Carvedilol" - te raau taero o te whiriwhiri, no te mea te reira te mea tonu he antioxidant. No te mea taputapu ārai whakahōhā o whakatū papa atherosclerotic.

rōpū tarukino Tuhinga

tohu katoa hoki te whakamahi o te beta-blockers whakawhirinaki i runga i te āhuatanga motuhake o te rōpū ngā tarukino. I roto i te blockers kore-whiriwhiri he tohu whaiti, mea whiriwhiri haumaru me taea te tono atu whānui. I roto i te whānui, e noa nga tohu, ahakoa e iti ratou e te eita o te whakamahi o te raau taero i roto i te tahi mau tūroro. Hoki taero kore-whiriwhiri e whai ake tohu:

• infarction myocardial i roto i wā, angina, okiokinga, katoa angina iu ;
• Atrial fibrillation normoforma me tahiforma;
• tachyarrhythmia pakohu ki mau ana i runga i me kahore ia ventricles ranei;
• kore ngakau (tonu);
• takawhita ;
• hyperthyroidism, hyperthyroidism, ki waho te raruraru o reira ranei;
• pheochromocytoma i te raruraru o te therapy taketake mate ranei preoperatively;
• migraine;
• Wāwāhi aneurysm te pūtahi o;
• tarukino waipiro withdrawal syndrome ranei.

Nā ki te haumarutanga o maha ngā rōpū o taero, rawa whakatupuranga tuarua, me te tuatoru, te rārangi o raau taero beta-blockers, maha puta i roto i te pūkete o te maimoatanga o te ngakau, me te mate iaia. E ai ki te auau o te tono, he tata ōrite ki inhibitors ACE, e kua whakamahia mo te maimoatanga o te kore ngakau, me te takawhita ki ratou syndrome pūkoro me kahore reira. Fakataha ki Diuretics, enei rōpū e rua o taero taea ki te whakapiki ake i te tümanako ora i roto i te kore cardiac ma'i.

contraindications

Beta-blockers, me te tahi atu raau taero, i te tahi mau contraindications. A no te mea ngāue taero i runga i receptors, he haumaru atu inhibitors ACE ratou. contraindications General:

• huangō, COPD;
• bradyarrhythmia, pakohu mate syndrome;
• poraka atrioventricular II tohu;
• hypotension symptomatic;
• hapūtanga, tamaiti;
• kore ngakau decompensated - kore ngakau II B-III.

Hoki mahi rite te tauhohenga pāwera contra i roto i te whakautu ki te tangohanga pūārai. Ki te whakawhanake i tetahi mate pāwera tarukino, te tarukino whakakapinga ki tetahi solves te raruraru.

Ngā pānga o te whakamahi haumanu o taero

A, no te tino whakaiti i taero angina te auau o te whakaeke angina me ratou kaha, whakaiti i te tūponotanga ka o ngā coronary whakapeka. I roto i CHF maimoatanga ki beta-blockers ki inhibitors ACE me Diuretics piki e rua oranga. He whai hua i roto i te whakahaere tachyarrhythmias rongoā me tukinotia patuki mōwaho auau i roto i te ana roro. I roto i te katoa, ki moni tauturu i te whakahaere i tetahi tohu o te mate ngakau.

Whakatau e pā ana ki te beta-blockers

"Carvedilol" me "Nebivolol" - ko te pai beta-blockers. Ko te rārangi o raau taero e whakaatu mahi maitai o te beta-receptors, kīnaki te rārangi o nga taero therapeutically nui matua. No te mea i roto i te mahi haumanu kia whakamahia rānei e toru o te whakatupuranga, ara "Carvedilol" ranei "Nebivolol" ranei te nuinga whiriwhiri mo te receptor taero beta-1, "bisoprolol", "metoprolol". ratou tono ara tenei ra, ka taea ki a koe te whakahaere i takawhita me ki te hamani mate ngakau.