Tetracycline: he whakatupuranga hou o analogues

Tetracycline - he rongoā paturopi, i timata ki te whakamahi i roto i te waenganui o te 50-doma o XX rautau. I teie mahana, e rave rahi kaiao ātete ki te tarukino kotahi whakatupuranga, kua urutau ratou, a na reira e kore te reira e whai ki te whai i taua pānga kino rite i mua. Otiia i roto i to tatou ra i roto i te mau tupuraa fifi, maha tūtohu tākuta tetracycline: pai te whakatupuranga hou o analogues akakoromaki ki te mate.

He aha te mea te tetracyclines (aratau o mahi)

He he iti ake i te 260 māngai, me te tata 40 taitara Group o tetracyclines me ratou pärönaki (tae atu āhua-waihanga). E piri ratou e te hanganga matū: whātatahia pūnaha 4-rarangi. hanganga noa ai pānga antimicrobial rite, me te tikanga o te mana.

Ko te mahi o tetracyclines he āhuatanga bacteriostatic (kaha ki te mutu i te whakatö o microorganisms) na roto i te hëoi (inhibition) o te kōtuitanga pūmua o ngā pūtau koiora.

production whānui pērā o raau taero i roto i tenei raupapa e tika ana ki to ratou kaha ki te whakaawe i te whānui o microorganisms ngā. I roto i te whakamutunga:

• Gram-pai, me te Gram-tōraro huakita,
• rickettsia,
• te māngai pūtake o trachoma,
• huaketo ornithosis,
• spirochetes,
• leptospira.

No te tau te roa kua whakawhanakehia te hanga o microorganisms maha ātete ki te tetracycline paturopi. He orotahi rite Tikanga, Ko reira whai hua atu. Formulations o taonga e rave rahi rerekē tetracycline kaha, te rahinga, kaha, me te tere o te mahi, te tikanga o te tono, tere o te absorption me excretion.

History o te whanaketanga

Ko te hītori o te whakamahi o paturopi haamata Pepuere 12, 1942, ka ko marere te rongoā paturopi tuatahi, mate i te paihana toto i whakawahia ki te University o Oxford. I roto i te torutoru ra ka anga ratou ki te whakapai ake, ka ratou mate tonu. kihai i kitea paturopi i roto i te rahinga tika.

Kua Ko te tino tuatahi o te rōpū nui o tetracyclines kua tohaina (o marama harore) chlortetracycline. I teie mahana, e mohio karangatia e ana taote me te tūroro biomitsin aureomycin ranei. tupu tenei kaupapa i roto i te tau 1945 i roto i Oxford. A i roto i te 1948, ka anga ana whakamātautau haumanu me te taiwhanga. Ko te katoa kei anake te tau i muri mai itehia tetahi paturopi o te rōpū - terramycin (oxytetracycline). A whakamahi reira hoki rongoā take ka anga i roto i te i muri tau, 1950.

Well-mohiotia ki katoa o tatou synthesized te tetracycline āhua-waihanga i roto i 1952. Na he anake tau i muri mai i taea te taratahi reira i te inu ahurea o te harore.

riro microorganisms ātete tiketike rawa, e taea ki te urutau hohoro ki paturopi, e tika ana ki te miramira raro ratou. e kore te mea i tohungia me te tetracycline tenei whakarau.

I teie mahana, e takoha pūtaiao ki te whakaputa i atu me te ake hou whakatupuranga o paturopi, a hohoro te hapu o rongoā whakahoutia ki taero hou ki kai kaha hou.

Na mahi rite he paturopi ka whakamahia

tika ua e te whawhai ki kaiao koiora taea anake tōtika Scientists. Rongoā paturopi - he taonga ōnā tawhiti i te inu ahurea o harore, pokepokea ai huakita ahei o te pānga te waipiro i runga i ētahi atu microorganisms ranei.

I teie mahana, i reira e rua ara ki te whakaputa i paturopi. E hanga ana ratou i nga hua kua ururuatia o ngā kaiao ora, tikanga āhua-waihanga ranei.

Tino korero, te tetracycline āhua-waihanga o nāianei - rongoa rite tawhiti i microorganisms ora. He maha pūtaiao whakapono e na roto i te te whakamahi i te hangarau hou paturopi he haumaru mō ngā tūroro.

Ko tino whanui hōkai tetracycline whānau o taero. Na, kei te whakamahia ratou:

• i roto i ngā tukanga inflammatory o nga Airways runga me raro (Bronchitis, tracheitis, kakā, epiemy pleural) meinga e iroriki tairongo;
• i roto i te maimoatanga o te mate romahā runga;
• mo te maimoatanga o te mate kanohi;
• i roto i te maimoatanga o mate hopuhopu o te ao urogenital (cystitis, prostatitis, pyelonephritis, gonorrhea, pakewakewa);
• mo te maimoatanga o whakapeka, me te ma'i mate hopuhopu o te ate, me te wahi biliary (cholecystitis, koripi);
• mo te maimoatanga o te mate kiri (abscesses, whewhe, panaritiums);
• i roto i te maimoatanga o āhua febrile (Q kirika, purepure Yellow Mountain kirika).

momo o raau taero

pai te ahumahi ho'oraa whakaputa paturopi i runga i taiao rauemi raw me taero āhua-waihanga. e kore te whakamahia anake teie mahana tetracycline - kua tangohia he whakatupuranga hou o analogues ratou wahi i roto i te hapu nui o paturopi.

Ko te kupu, Ka taea e i roto i te semisynthetic kia huaina doxycycline me methacycline (pārōnaki oxytetracycline). Ko te whakatupuranga i muri o te tetracycline me maitai morfotsiklin glikotsiklin. He hou ngā faaineineraa "oleandomycin 'e hāngai ana i runga i oletetrin me olemorfotsikline.

riro rongonui hōrapa minocycline.

Ko tētahi o te teie mahana tino hua ko "Doxycycline" me ona pärönaki, engari me ki te taero hou ka hua "Tetracycline". I te wa ano noho ia i te wahi nui i roto i tenei whānui o paturopi.

Rerekē me ngā puka inenga. I roto i te whakamutunga rau tau reira ahiri anake pire me te nehu-werohia.

Ko te puka tuatahi o tetracycline he puehu. E diluted ratou i roto i te saline me patia intramuscularly. i te tīmatanga i te pota tiketike e tika ana ki te ihirangi iti o te whakauru kaha, a ka he tino mamae werohanga. I roto i te heke mai, ka anga me werohanga ki te tono i te papa.

Papa me capsules

I teie mahana paturopi tetracycline - he whānui o liofizilatov, papa, hinu, makaka kanohi, syrups ngā. Na i reira he capsules kei roto tetracycline. He orotahi o papa i roto i te tahi mau whānuitanga solves te raruraru o te pānga kino o te rongoā paturopi i runga i te puku, me te wahi kūnatu. I tčnei wā, te nuinga o te rōpū o te paturopi tetracycline waha tukua tika i roto i capsules ranei papa, kiriata-Uwhi. He taka i runga i te pärönaki e whai ake nei enei:

• doxycycline ( "Bassado", "Vidoktsin", "Dovitsin", "Doxycycline"),
• oleandomycin ( "oletetrin")
• oxytetracycline me erythromycin ( "Eritsiklin")
• minocycline ( "minocycline")

Hoki, e hāngai ana i runga i te tetracycline tūturu "Akos Tetracycline", "Tetracycline Lect" tetracycline hydrochloride.

whakaaturia te whakamahi o enei puka inenga te mo momo katoa o mate ā-: mimi, bronchopulmonary, intestinal. E whakamahia ratou rite te tānga ki te maimoatanga o mate Ent me ngā raruraru kiri. Whakahau taero rōpū tetracycline o ngā pakeke me ngā tamariki i 8-12 tau (i runga i te tarukino). Hei tauira, tetracycline me methacycline whakahau te tau o 8, doxycycline - 9, oksitetartsiklin - 10.

Heoi, e kore e hoko i runga i to ratou ake hei utu o te hua whakaritea, e hāngai ana nei i runga i orotahi tetracycline. Na tohutohu, āta ako i mua i te maimoatanga, ka huihuia e pā ana ki te tarukino kore e arotake pai te taurangi e te tikanga he tika hoki koe. Ae, ka taea e waiho e ratou te taua rite whakaahuatia i roto i te whakarāpopototanga, me koutou tohu ngā; Ae, he hoa, korerotia koe ki tenei rongoā, ongo'i pai i muri noa i te papa tuatahi; ae, e tata ōrite i roto i ngā rongoā e rua nga kai kaha ... Ko reira he kotahi mea, a kore e te reira tupare o tukurua tohunga. I te whakarite o te tākuta e ki pūkete maha āhuatanga o te tarukino. Ka rite ki te tikanga, tūtohutia ratou he pai hoki tenei take ngā te rongoā. Heoi e kore e whai wāhi i roto i te mahi motuhake.

He aha te mea te lyophilizate?

Kei te rite te reira i roto i te ara motuhake (na roto i te mīti me te korehau whakamaroke) paura, i reira i diluted e te hangarau motuhake, me te te whakamahia mō te werohia. kia intramuscularly and pâmuhia werohanga. kua pera maha painga, e taea te rongoa reira te lyophilisate hoki nui roa atu i te paturopi whakaputaina e te tahi atu tikanga, kua kua riro pai me tere te kukū teitei o te kaihoko painga.

Heoi, i roto i te faaineineraa o te otinga, me tona whakataki kia piri tino ki te tohutohu, te kore ai e ngaro te tarukino ona āhuatanga painga ranei ara kino te manawanui.

Ka taea te whakamahi Tetracycline iho rite papa, capsules me paura-otinga. hua i runga i reira e kore e tio-maroke, engari he maha o ona hou-whakatupuranga orotahi ( "Vidoktsin", "Tagitsil") e wātea ana anake rite te lyophilisate mō werohia.

He aha atu e taea te whakakapi ki te tetracycline? Orotahi tona whakaritea rawa pinepine - "Doxycycline". Rongoā e hokona i roto i te capsules rite te hua tia-maroke ranei.

Tetracycline ki nystatin

Tenei whakatupuranga hou o te tarukino e kua kore anake te mahi antibacterial engari ano anti-fungal. Te reira i tetracycline me nystatin hakari i rite moni, te mea he whānui o te mahi, e whakamahia ana i roto i te mate Ent, kakā, cholecystitis, mate paipai, mate intestinal, hakihaki, mate hopuhopu o te wheua, me te kiko ngohengohe. Wātea i roto i te Papa Film-pani.

e kore e rongoa rawa tika i huaina "Nystatin" "oletetrin" papa "Tetracycline" whakakapi "tetracycline ki nystatin" He maha ngā pae. e kore te analogues e he ōrite miramira me aratau o mahi ki tenei tarukino mau whakaputaina. He wāhanga noa nga whakatakataka i runga ake o nga mahi.

Syrups me te aukati

Whānui e whakamahia ana i roto i te aukati pediatric, me syrups ona. e matau ana ngā mātua katoa te pehea e rata ki te inu i te pire kawa, e kore e te okotahi, me tamariki tetracycline (papa). whakaaetia slurry te ki huna kanohi i te reka kino o te tarukino, hanga i te reira fariiraa atu whakamarie - Analogs. Pūtaiao nuinga hua puehu motuhake e e ka diluted ki te āhua slurry, a ka he tirikara.

Ka rite ki te slurry paura hua ano tetracycline me tetracycline hydrochloride. I roto i te raau taero o te whakatupuranga hou e taea te huaina doxycycline hydrochloride, doxycycline monohydride, oxytetracycline hydrochloride.

Ko te whakamahi o te whakatārewatanga o te tino nuitia mahi ki maremare me te māuiuitanga romahā i roto i ngā tamariki.

hinu

Hinu i runga i tetracycline hangaia mō te whakamahi waho, me te mo te maimoatanga o mate kanohi. E kore e pera, ui atu ahau ki tetracycline hinu roa i mua, i whakahaere reira noa ki ngā tamariki (i 8 tau). Ko te wā e kore e tu tonu, kua whakakiia te mākete ho'oraa ki taero hou e hiki taero wa to tatou whaea me kuia. He aha e taea e whakakapi tenei hinu? Tetracycline analogs kua huaina tatou i runga. Mai i taka i runga i tona tūāpapa, whakaputaina i roto i te puka e taea te huaina "Kolbitsion", i reira, i roto i te tua ki te tetracycline, chloramphenicol me ngā kolistimetat. Pai-kï "Tobradeks", Heoi, i konei te taonga tobramycin kaha, a kahore he ia he orotahi o tetracycline, engari kua he pānga rite.

kia hoki hinu mo te tono waho (tetracycline) whakakapia tarukino "Akos Tetracycline". I roto i te meka, he maha nga whirinoa tūtohutia, engari e kore e te ratou taonga kaha whakaaro e tatou he rōpū o raau taero, ratou anake i te pānga rite.

pata

Te whakatupuranga hou i runga i te pūtake o ngā hua doxycycline wātea rite pata kanohi. Tenei, hei tauira, "Innolir", he mea whai hua i roto i te maha mate kanohi.

whakakapi te reira i te rongoā paturopi pērā i tetracycline orotahi "Oxytetracycline" (otinga) e taea te pēnei herenga anake. A ki te tanu taea e ratou kanohi anake i roto i te wā tino me i raro i te mātakitaki o taote.

Ka rite ki te whakamahi ophthalmic me tetracycline hinu kanohi (1% me 3%), engari taka o te tahi atu paturopi o tenei rōpū kore mahi.

He aha e te tauākī o contraindications

E mea pinepine, ki te kore koe e taea e te whakamahi i te raau taero i runga i te pūtake o taua matū rite tetracycline orotahi me te whakakapi i roto i te kēmu rōpū maitai. Ka whakahau te tākuta he whakatupuranga hou o te tarukino (doxycycline, oxytetracycline, methacycline), e taea te whakamahi i roto i tenei āhuatanga, a ka waiho i te reira whai hua.

I roto i te contraindications noa e:

• tauhohe mate pāwera ki tetracycline;
• hapūtanga;
• hohipera;
• Tamariki i raro i 8 tau o tau;
• nui kino ate.

Ko te whakamahi kino o te tetracycline me ona analogs?

He āhuatanga o te paturopi katoa ko e meinga e ratou he momo o ngā kino. he kahore okotahi, me tetracycline. hoki i analogues o (tetahi o te whakatupuranga hou) te nuinga o ratou. Ko te kupu, ka kia riro nga pānga taha tino noa i roto i te wā poto:

• mate o te hiahia, whakapairuaki ruaki ranei;
• whanoke me te ānini;
• korere, flatulence;
• mumura o te ararewa o te puku, gastritis, me proctitis.

Ki te whakamahi auroa, e maha tuku tūroro ki roto i te tohu kino:

• ino i tohua o niho i tohu;
• stomatitis;
• exacerbation o mimi mate wahi;
• nui haere te tūtohutanga ki te rā;
• te whanaketanga o te mate fungal.

E taea e ahau te whakakapi i te tetracycline tōtika?

E mea pinepine i tenei pātai tiaki ko wai te mea tahuri ki to ratou hauora, me te pānui i te tohutohu mo te whakamahi o te hua whakaritea.

e kore e taea te huaina medicament kinokore, te taonga kaha matua ko te tetracycline. Orotahi (tetahi o nga rōpū) rite te taketake, ka whai ano te rota o contraindications. Heoi, kia mahara ai e kua whakaritea te raau taero tākuta, me te aroaro o e kua ia ki paunatia nga painga pea i te whakamahi, me te taea nunu'a kino.

Doctors whakahau rongoā (pā tenei ki te rōpū tetracycline) anake i roto i te wā i reira tami nga painga nga mau hopearaa kino taea.

Takitahi te whakamahi i tenei tarukino ona analogs ranei i roto i tetahi take e taea. E pā ana hoki tēnei ki wā hinu. I muri i te roa e taea ratou te whakamahi arahi ki raruraru nui.