Prokinetics - he aha te mea te reira? he whakatupuranga hou o prokinetics: rārangi

Prokinetics - he aha te mea te reira? I roto i nga whenua Kihi, kahore he whakaaro e pā ana ki te mea rongoā e ngā i roto i tenei rōpū, na gastroenterologist katoa whakatau ia e kawea mai i roto i tenei rārangi, me te mea e kore. Prokinetics - he aha te mea te reira? Ko te aha tatou e tamata ki te kitea i roto i.

Whakamarama me te whakamārama poto

Prokinetics - he aha te mea te reira? Tenei rōpū o raau taero e whakaongaonga te motility o te ngongo kūnatu me ārai ngaru anastaltic.

Kei te maha haere tahi mate gastrointestinal i Reflux o chyme i nga wahi o raro rawa o te ngongo intestinal i roto i overlying, takahi irava bolus ranei te stagnation i roto i te wāhanga whēkau. Katoa o enei tohu e pā ana ki waimaero whakatairanga chyme i te ngongo kūnatu, ka tango taea te tohu e, e pa ana te hukihuki o te uaua maeneene i roto i ona taiepa. Ko te aha prokinetics. Ratou pānga haumanu he tika ki te ārai o te whakawhiti katote tikanga (dopamine, receptors 5-HT4, ngā) ranei mana i runga i te pākia o acetylcholine. Whakatutuki pānga haumanu he tika ki te nui nui haere o acetylcholine i roto i te kapiti synaptic ranei te amplification o ngā hua cholinesterase e whakatairanga ana i te whāwehe o Ach, hua whakaiti Ach kūmuri io.

pānga physiologically i te raau taero puta ki te whakapiki ake i cardiac oro sphincter esophageal, hōneatanga o tirotiro puku, te ruruku i waenganui i te antrum me te duodenum, hua ioio whēkau.

Ko te rōpū tuatahi o taero

Prokinetics - raau taero e aukati dopamine D2-receptors, ai whakaongaonga mahi uaua, me te whakarato muka gastrointestinal pānga antiemetic. Ēnei rongoā ngā: "metoclopramide" (whakatupuranga tuatahi māngai - "Reglan" me "Raglan"), "bromopride", "Domperidone" (whakatupuranga tuarua), "Dimetpramid", "Itopride".

raau taero Prokinetic, whakamahia i roto i te maimoatanga o te mate gastroezofagialnoreflyuksnoy (Gerd), YAZHDPK, dyspepsia, pūāhua mahi, whāiti o te pū kai i muri i whara, me rite ki te hua o adhesions, wawao postoperative paresis i te puku, te ngangau o te matamua o te ate, flatulence.

Hoki prokinetics - raau taero e taea te whakamahi mō te whakapairuaki, me te ruaki meinga e pau takahi o te kai ture ranei, mate o etiology viral kitakita ranei, hapūtanga i roto i te huatū tuatahi, whakapeka iti hoki coronary, upoko whētuki, rehunga, radiation, me te hahau. Koretake mā te ruaki takenga vestibular, rite kore e te reira pā te taringa waenga me te oblongata medulla.

tauturu i Antipsychotics ki te ruaki

"Sulpiride" me "Levosulpirid", ko te neuroleptic ki te tikanga rite o mahi, ano to ratou he pānga pai anti-hiaruaki, kia taea te whakamahi i roto i te mahi gastroenterological.

"Metoclopramide" (prokinetics): tohutohu mō te whakamahi

"Metoclopramide" - he stimulator tika o te uaua maeneene me te he nga āhuatanga e tika ana katoa ki te whakatutuki i ngā hua hauora nui, engari no te mea o te tauārai gematogistologicheskie uruhanga kia whakamahia ki te tūpato. Pea ngā pānga taha pērā i spasm o nga uaua kanohi, te tohu o "waewae o te tikaokao", protrusion naki o arero, disorders bulbar, uaua mamae ekrtraokulyarnyh, torticollis pakū noa, te āhua nui o te uaua extensor, syndrome, somnolence, ngoikore, tinnitus, pāhoahoa a Parkinson, manukanuka, te whakama.

I roto i ētahi wā, e minaminatia ki te tango i prokinetiki? ka mea Tohutohu mō te whakamahi o te whakamahi houhou i roto i te wā o te hypersensitivity ki te tarukino, he puku o te uho adrenal, te tutukitanga intestinal, perforation o te whēkau, me te meinga ratou toto, te pukupuku prolaktinozavisimoy, haurangi me disorders extrapyramidal, ki runga ki te 16 wiki o te hapūtanga o te tamaiti, i roto i hohipera, tamariki i raro i 5 tau. kia whakaritea Whakatūpatotanga i te whakawātea iti o creatinine, nui haere te pēhanga toto, huangō, pakeke ake ki te 14 tau.

Horomia te rongoā te hawhe haora i mua i te kai, i runga i te papa i 9:00, 12:00, 15:00, me 18:00. Duration o te maimoatanga - wha ki te ono wiki, i ētahi wā e taea te atu te reira ki runga ki te ono marama.

Ki te te puka tuku - wai, kua whakahaerea reira intramuscularly pâmuhia ranei. Hoki ngā pakeke me ngā tamariki i runga i te 14 tau - 10 mg. Mōrahi ia kotahi te wā - 20 mg horopeta rā - 60 mg. Ka taea te diluted nga tirotiro o te ampoule i roto i te saline isotonic 5% otinga kūhuka ranei.

"Domperidone": tohutohu mō te whakamahi

"Domperidone" ko atu whiriwhiri pūārai dopamine receptor, haunga kore ô i te BBB, Heoi ka te fariiraa ko kore whakawhanake pānga taha whakaahuatia ana i runga. Heoi, te whakanui ake i te secretion o prolactin, pāngia e te reira gynecomastia, galactorrhea, me te ngaro o te waipara. I tua atu, pūrongo tūroro he hikaka kiri, mangai maroke, korere me pāhoahoa.

Ehara i tūtohutia hoki te whakamahi mō te iwi ki te mate pāwera ki wāhanga o te rongoā, toto i te wahi gastrointestinal, te tutukitanga intestinal, prolactinoma, hohipera, tau noa 5 tau o tau te taimaha ki runga ki te 20 manokaramu ranei. Whakatūpatotanga ki te tango i roto i te hapūtanga, tākihi me te / ranei iti hoki ate.

Inu hoki e rua tekau meneti i mua i ia kai ki te 10 mg, ki te hiahiatia, a taea inu i mua i te haere ki te moenga. Ko te horopeta mōrahi ia ra - 80 mg. Ki te reira i roto i te maimoatanga o waikawa, te whakaiti i te secretion o wai pekitīlia, kia waiho ratou wehe i te domperidone inu, te faaiteraa i kai kai.

"Itopride": tohutohu mō te whakamahi

"Itopride" fakatahai nga āhuatanga o te enemi dopamine receptor me pūārai o acetylcholinesterase. Whai i runga i te pūnaha hypothalamic-rapae o-adrenal, te whakanui ake i ngä nohanga o somatostatin me te whakaiti ira adrenocorticotropic. faaite te pānga kino te rite leukopenia, thrombocytopenia, tauhohe hypersensitivity, hyperprolactinemia, whakapairuaki, faaati, jaundice. I roto i te fariiraa, he mea e tika ana ki te aroturuki i te āhua o te toto piringa, ka whakarite i reira he kore pānga taha.

Ehara i tūtohutia hoki te iwi ki te hypersensitivity o momo tonu roa ranei, hītori toto gastrointestinal, obturating te lumen intestinal kōpeketanga ranei o te tinana ke i waho, i raro i te tau tekau ma ono nga tau, hapūtanga, ū o.

tangohia te raau e waha i te aroaro o kai mo 50 mg toru nga wa o te ra.

Te raveraa ra "acetylcholine"

Tenei rōpū ngā:

• "Aceclidine" (M-cholinomimetic);
• "Fiziostigmin" "Galantamine" "Tegaserod" "Prucalopride" (reversible inhibitor cholinesterase)

no enei taero ki anake wāhanga kamupene o prokinetics no o ratou pānga taha: pānga i runga i te utu o ngā katote pāhare pāporo, me rite ki te hua, tawharara wā QT, e tika ana ki te raruraru o te manawataki cardiac. He maha o taero kua mawehe atu i te mākete pharmacological mō tenei take.

"Aceclidine": tohutohu mō te whakamahi

Prokinetics - he aha te mea te reira, me pehea ka ka ki te whakamahi i a ratou? I roto i tetahi take, kia mohio ki te kōrero i te tākuta, me te ako anga o te tohutohu mō te whakamahi.

"Aceclidine" Kei te whakamahia ki te karo i te mate o āhua o te wahi kūnatu me te tōngāmimi i muri pokanga, te whakaiti pēhanga intraocular, reira e taea te whakamahi i roto i te Ophthalmology. Puka Hua - werohia, patia subcutaneously ki 2.1 ml o te otinga 0.2%. Max i te wa - 0.004 g, me ia kaua e nui ake 0.012, te pānga taha - ptyalism, sweating, me korere.

Contraindications ki te whakamahi he CHD, HDL teitei, huangō arahau, me ētahi atu parkinsonism hyperkinesias, hapūtanga, te toto i te kōhao puku.

"Fiziostigmin" whakamahia te matua i roto i te mahi ophthalmic, engari ka taea e ētahi wā te whakamahi i roto i gastroenterology i te paresis intestinal. patia te raau i raro i te kiri o 0.5 - 1 ml o te otinga 0.1%. Ko te nui mōrahi o te tarukino ia ra e kore e nui 0,001 g

pānga te taha Ko te whakapakari o salivation, bronchospasm, spasm intestinal o nga uaua, huringa i roto i auau ngakau, haehae.

Contra-tohu: angina, haurangi, huangō, mīhini tutukitanga waewae intestinal, peritonitis, sepsis, hapūtanga.

"Galantamine": tohutohu mō te whakamahi

"Galantamine" i roto i te wā ngā whakamahia te rite te enemi mō relaxants uaua i roto i te wā postoperative ki te hekenga i roto i uaua āhua o te whēkau, me te tōngāmimi. Contraindications ki te whakamahi he hypersensitivity, haurangi, huangō, te pēhanga toto i runga 139/99 mmHg, COPD, occlusion pūkaha o te tau mahani intestinal, waimaero mahi tākihi, tau 9 tau. Limited ki te whakaaro o te hapūtanga i roto i te wā i reira tami nga raru e pea nga painga. I roto i te hohipera, e taea te tuku ki te tamaiti i roto i te waiu.

pānga taha: whakaiti o auau ngakau, TTP, AV pā, arrythmia, whakapairuaki, ruaki, korere, dyspepsia, mamae uaua, taikaha mimi, haematuria, faaati.

kia kia whakahaerea reira subcutaneously, intramuscularly, e pâmuhia, transdermally,-waha. whakaritea te horopeta te takitahi, e hāngai ana i runga i te hītori o te mate, a kia te papaki e te rata haere. Ko te horopeta rā toharite mō ngā pakeke - i te 10 ki te 40 mg, wehea ki e rua ki te wha werohanga.

He whakatupuranga hou o prokinetics

I runga i te pūtake o te tenei ra Itopride hua taero pērā i "Ganaton", "Itomed", "Pramer". Ko tētahi o te hōu me whai hua te nuinga ko te hunga prokinetiki whakatupuranga hou rite "koordinaks" me "Prepulsid". Ahakoa ka taea e ratou meinga pānga taha nui i roto i te ngakau.

Ko te tino rongonui i roto i gastroenterologists tonu "Motilium" (hohe whakauru - domperidone), e fakatahai te kounga o metoclopramide, engari e kore e whai ona nunu'a kovi.

He aha e nga pprokinetiki whai hua tino? Rārangi o ngā hua inaianei ngā:

1. "Itopride" (whakauru hohe) - "Ganaton", "Itomed", "Primer" (ingoa arumoni).
2. "Metoclopramide" - "Raglan" "Reglan".
3. "Cisapride" - "koordinaks", "Prepulsid".
4. "Domperidone" - "Motilium", "Motilak", "Motinorm", "Passazhiks".

Tatou e matau i teie nei e te prokinetic taua. Whakarārangi ratou rite kite koutou, he mea nui. Engari kia mahara, i mua i te whakamahi i tetahi rongoā kia kōrero ki tō tākuta! E noho hauora!