"Montelukast": arotake, tohutohu me analogues o te tarukino

"Montelukast" - e pā ana ki te arotake tarukino e taea ngāwari te kitea i runga i Ngā Huinga ipurangi me ngā wāhi i whakatapua ki te raruraru o te huangō - te enemi matarohia o te leukotriene D4-receptor. Kei te whānui whakamahia te tarukino rite te turanga i roto i te therapy, me ki te ārai whakaeke āhuatanga o te mate. hanganga tautika taea te whakamahi o te tarukino mo te maimoatanga o te tūroro o tata tetahi rōpū pakeke.

Puka tuku

Ngā take he aha riro "montelukast" te nuinga arotake pai, he rota. Heoi, ko te mea tuatahi e mau koutou kanohi - ko tenei, o te akoranga, te Whārangi o papa, hokona i raro i te ingoa o te raraunga hokohoko.

I te kau nuinga te tukanga e toru kopu. Ko reira e pā ana ki te pire paerewa ki te kōpaki konumohe (1 kōwae kei 10 mg o taonga kaha) me o ratou analogues ngaungau (4 mg me te 5 mg te whakaatu i o te kaiwhakahohe). pūtake Base i roto i wā e rua, mahi montelukast konutai, engari te hanganga o te maha wāhanga rerekē ngaahi houalotú - Mannitol me aspartame e hakari i roto i ngā tauira te tikanga mo te ingestion tonu i roto i te whakamahi.

I roto i te kōrero tino maha pops reira ake te pātai o loi, e teie nei, a ka puta i roto i mekameka rongoā. Tiaki ki tinihanga e taea e, ki te kore wā aro utu ki te ahua o te hua pharmacological.

I roto i ngā, ngaungau pire ki 4 milligrams o whakauru kaha, he āhua porotītaha me te urukehu māwhero (whakaahuatanga hāngai papa ki te hā here, ki te whakamahi o ētahi atu flavorings rerekētanga whakaaetia), ka tohua ki te tau "4" i tetahi taha. Analogs i roto i nei te whakauru matua kaha, ko te 1 mg atu - a tawhio noa, me te tapanga "rima". Pire rite te anga āhuahanga rite he tapawhā; kirīmi ratou, ka taua te tau "10".

hononga pharmacological

"Montelukast" (tohutoro whakaahua āhuatanga i reira i whakapataritari kaiwhakahohe matatini e tino onge pāwera) - ko te māngai angamaheni o taero te rōpū antibronhokonstriktornyh tenei. Te hātepe e āhei ana mahi ki te korero o te "hononga tata" ki intermedianty / prostaglandins me thromboxanes.

Ko te mahi matua o te tarukino - ārai cysteinyl leukotriene "pūoko" o te pūnaha romahā. mau tonu ēnei receptors mahi nui i roto i te whanaketanga huangō arahau, me te whakaongaonga hoki e ratou te kōtuitui o secretions e ka piki me fakafaingata'a'ia'i te mucosa.

arata'i te horomanga te wā ki te whakaiti nui i roto i te pakeke o ngā tohu i roto i te papamuri o te hekenga whānui i roto i te maha o whakaeke huangō (rite tuhia e tūroro maha, e kua kitea huringa pai i roto i nga ra tuatahi o te therapy).

āhuatanga pūkoro

"Montelukast" (arotake taka rongoā whakaaro e he iti ki te kaupapa here utu o ngā kaiwhakanao te whiriwhiri tūturu o te tu-mai, arā, te takitahi taero-taurite, kōrero ki tona hanganga rāpoi ōrite-hanganga ko te wāhanga matua, i reira e rave rahi taime atu te utu atu i te faaineineraa whakaahuatia), tomo ana ki te wē toto, herea maitai me ona pūmua. I roto i te rangahau haumanu, te hua i tuhia i 99, 37%. I te wa ano, ko tona bioavailability i roto i te rahi tika ki te tukanga o te issuance. Hei tauira, te kai papa 5-koma haumano Nireaha ki te absorption e 73%, te mea analogues ki membrane Ōseni i roto i nei i reira ko te 2 ngā wā matū kaha atu, - anake i te 64%.

He āhuatanga rite ki te hawhe-ora o te kaiwhakahohe: Wae ngaungau pire, mā te pangia pākia, mahue te tinana i muri i te 2 haora i muri i fariiraa, engari nga mea timatanga wāhanga o papa tikanga - i muri i 180-200 meneti. I roto i tenei whakawātea wē rerekē i waenganui i 43-45 ml / meneti. A, taa, pahemo atu% 0.2 anake o te horopeta te takere mimi. Piro, i whakarite, - neke atu i te 85%.

Mai i nga kōrero o mana whai, whai reira e he ōrite pai i roto i te tūroro o tane e rua te tukanga pharmacokinetic, me e hanga etahi whakatikatika nui tau me te māuiuitanga tākihi mo i roto i te tātaitanga o te tohanga o ia rā o te rongoā te hiahiatia. Ko te kore o te ate, tautautefito ki he taimi tae mai te reira ki te mate kino, tika tokanga makehe i roto i te faaineineraa o te hōtaka whakaora.

Tuhinga hoki

A, no te whakatikaia e te whakamahi o "montelukast" arotake tarukino (tamariki rongoā tūtohutia i roto i te puka o te kapia, pire, anga membrane pani, he mea tika ki te whakarite ngā pakeke anake me taiohi), mahue i runga i Ngā Huinga, o te akoranga, te āwhina ki a tatou mahino. Heoi, anake arahi i te whakaaro o ētahi atu iwi - he mea he hape nui, no te mea kahore kōrero ki te rata, "ki te tautuhi i te" momo o huangō, ka tino nui - ki te kitea i roto i nga take i tona tupu he tata e taea hoki.

Ki te whakaaro ki te tauākī e pā ana, te porowhita reira tohumate, aorangia hoki me ētahi atu tikanga i tuhia e whai ake:

• mamae arahau pōreareatanga e kawenga tinana nui;
• Kaupeka / Rhinitis ma'i, āhua pāwera o te takenga;
• huangō;
• te hiahia mō āraihia.

Te inenga tino arotau

"Montelukast" (he urupare kino tino uaua ki te kitea, no te mea kua roa kua pai whakamahia te whakauru hohe rite te wāhanga matua o te maha tarukino) te whakahaere-waha, kotahi te ra, ka kore e mahi ki te hōtaka "parakuihi - tina -. Tina"

No te papa chewable, 4 mg me 5 mg he toketaá taua ture:

• tamariki te pakeke i waenganui i 2 me 5 tau: 1 kōwae o te hua (4 mg) he ra, i te taotoraa, tae noa te whakatutuki mana o ngā tohu, me te roa o te akoranga herea mō te 2-4 wiki ki te whakatika i te pānga hua;
• tūroro 6 ki te 14 tau tau: te aratau taua, engari he auau kotahi-wā o - 5 mg.

No te pire ki te Uwhi konumohe hāngai e whai ake tūtohutanga:

• ngā pakeke me ngā tamariki i runga i te 15 tau, e mate ana i te huangō arahau Rhinitis ma'i ranei: 1 Unit (10 mg o rauemi) / ra i roto i te ahiahi;
• ki te ārai cramps: te horopeta taua i runga i te wā i te roa āputa o 14-28 ra.

pānga taha

(Whakaaro arotake e ara i roto i te hanganga ture ki tonu ki te kaiārahi e pā ana o tauhohe mohiotia ki te aroaro o kai ki te mutunga e kore e taea te waho) "Montelukast" ako tūnga te rite te tarukino haumaru pea, engari ki te, kia āhei te kore-motuhake "whakautu" i runga i te wahi o te tinana i roto i te wā takitahi tonu taea.

tauari tukua:

• GI: korere, mangai maroke, mamae i roto i te syndrome puku, whakapairuaki;
• ngakau me te toto rārangi: he hua rawa nui i roto i te auau he pini;
• ponana kiri, urticaria, kanokanototo rohe;
• pūnaha romahā: ihu mātihetihe, me te maremare;
• CNS: whanoke, te rohirohi, te tūāhua o te whārua tētahi ki rōpū whakamātau tinana nui;
• musculoskeletal: myalgia me arthralgia (tae atu, haehaea iho.).
• Ētahi atu: tohu āhuatanga o whakapeka mate romahā me te rewharewha.

Whāititanga me contraindications

"Montelukast" (tohutohu mō te whakamahi ko te arotake tino pai, me te mōhiohio i roto i roto i reira, i roto i ngā o te objectivity, ngā pātai i te mau melo o te hui, ko te tata kore i reira) e kore e tono ki te:

• kitea te reira i te nui haere te tūtohutanga ki te hanganga o ngā rongoā (te tikanga pono mo momo katoa o papa);
• pāngia onge mate riro, tae atu te hunga i roto i nei e kore e te rauropi whakawhenumi galactose ite hē lactase tino ranei (e kore e tenei here te tono ki ngaungau pire);
• taimaha te manawanui kei ki phenylketonuria;
• e kore kua te manawanui ano tahuri rua tau (mō papa Uwhi "rohe tau" - 15 tau).

Tuwhena rawa: Tohu me Treatment

Kua whakaaturia Studies, "Montelukast" 4 mg (faahororaa e pā ana ki tenei ahua arumoni o te kaiwhakahohe, i roto i te meka, ōrite ki te kōrero e kua whakatutuki ngaungau analogs kei roto 5 mg o taonga kaha) i roto i te taikaha o te auau kohi ia he i runga i te pānga taua rite papa mg 10 . Ka taea te kite i nga tohu tino korerotia o tuwhena rawa i roto i te tūroro rōpū teina. Ngā pakeke, ara ka tango 200 mg / ra mo te 5 marama, i kitea etahi tauhohe rerekē.

Ko te wā tohu kotahi o nui haere ngä nohanga o te tarukino ko:

• matewai e kore e tineia;
• te momoe;
• puku mamae rohe;
• ruaki;

kawea maimoatanga i roto, e hāngai ana i runga i te pikitia haumanu kitea. Mōhiohio e pā ana te whai huatanga o te tātari toto ngaro.

taunekeneke Drug, me nga analogues tino rongonui

"Montelukast" 5 mg (arotake o ngaungau tauira mahue e pediatricians, kohuatia iho ki te whakaaro e te raau taero, kahore feaa, e tika o te aro o te mau metua taitamariki) ki, me ētahi atu momo o te leukotriene receptor enemi, ka whakamahia i roto i te whakarara ki te āpiha e hāngai ana whakatere i te akiaki pai : tohu o huangō riro iti nui, heke te maha o whakaeke. Heoi, e kore te tūtohu te withdrawal ohorere o te therapy kawea i roto i runga i te pūtake o corticosteroids hau.

Tino rerekētanga i roto i te tukanga pharmacokinetic whai wāhi theophylline me prednizola kitea. Ko absorption i "uniana" ki phenobarbital heke i rite nui rite 40%.

Tauhohenga e tautāwhi i te kōtuitui o CYP3A4 isoenzyme, kia whakamahia anake i raro i te tirotiro hauora.

analogs Structural e e tino maha kitea i runga i te hoko:

• "Monkasta".
• "Singlon".
• "Singulair".
• "Ektalust".
• "Singuleks".

"Singulair" ranei "montelukast": arotake o ngā tākuta, me taka rongoā

E ai ki pharmacologists tohunga, te tautohetohe e pā ana ki nei o te raau taero, ko te haumaru me te ake whai hua, horihori, mai "Singulair" me "montelukast" e tetahi me te turanga ho'oraa taua. Just haere te rēhita ārai ingoa hokohoko tuatahi, a ka he te ao te tuarua. rata takitahi me tūroro, Heoi, e he tirohanga rerekē, me te whakaaro rongoā tohaina i raro i te whare tira, te whakatau tika anake.